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anti-CD79a antibody :: Mouse CD79a Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS370041
Unit / Price
5 Control Slides  /  $130 +1 FREE 8GB USB
0.1 mL (Concentrate)  /  $190 +1 FREE 8GB USB
3 ml (Prediluted)  /  $220 +1 FREE 8GB USB
7 ml (Prediluted)  /  $335 +1 FREE 8GB USB
0.5 mL (Concentrate)  /  $390 +1 FREE 8GB USB
1 mL (Concentrate)  /  $570 +1 FREE 8GB USB
15 ml (Prediluted)  /  $570 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD79a, Monoclonal Antibody

 Also Known As   

CD79a

 Product Gene Name   

anti-CD79a antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 19; NC_000019.9 (42381190..42385439). Location: 19q13.2
 OMIM    112205
 3D Structure    ModBase 3D Structure for P11912
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 Clonality    Monoclonal
 Isotype    IgG1/K
 Clone Number    JCB117
 Host    Mouse
 Species Reactivity    Human, Dog, Cat
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 Form/Format    CD79a is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
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 Control    Tonsil, Lymph Node
 Localization    Membranous
 Reactivity Note    Paraffin, Frozen
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 Preparation and Storage    Store at 2 to 8 degree C in the dark.
 Other Notes    Small volumes of anti-CD79a antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CD79a antibody

   CD79a is non-covalently associated with membrane-bound immunoglobulins on B-cells to constitute the B-cell Ag receptor. CD79a first appears at pre B-cell stage and persists until the plasma-cell stage, where it is found as an intracellular component. CD79a is found in the majority of Acute Leukemias of precursor B-cell type, in B-cell lines, B-cell Lymphomas, and in some Myelomas. CD79a is a B-cell marker that is generally used to complement CD20. This antibody will stain many of the same Lymphomas as CD20, but also stains more B-precursor Lymphoid Leukemias than CD20. CD79a also stains more cases of Plasma-cell Myeloma and occasionally some types of endothelial cells as well. CD79a will stain many cases of Acute Promyelocytic Leukemia (FAB-M3), but only rarely stains other types of Myeloid Leukemia.
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 Dilution Information of anti-CD79a antibody    anti-CD79a antibody Dilution Information image
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 Immunohistochemistry (IHC) of anti-CD79a antibody    anti-CD79a antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for CD79a. It may not necessarily be applicable to this product.
 NCBI GI #    1087007
 NCBI GeneID    973
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 UniProt Primary Accession #    P11912 [Other Products]
 UniProt Secondary Accession #    Q53FB8 [Other Products]
 UniProt Related Accession #    P11912 [Other Products]
 Molecular Weight    25,038 Da
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 NCBI Official Full Name    CD79a
 NCBI Official Synonym Full Names    CD79a molecule, immunoglobulin-associated alpha
 NCBI Official Symbol    CD79A [Similar Products]
 NCBI Official Synonym Symbols   
IGA; MB-1
[Similar Products]
 NCBI Protein Information    B-cell antigen receptor complex-associated protein alpha chain; ig-alpha; MB-1 membrane glycoprotein; surface IgM-associated protein; CD79a antigen (immunoglobulin-associated alpha); membrane-bound immunoglobulin-associated protein
 UniProt Protein Name    B-cell antigen receptor complex-associated protein alpha chain
 UniProt Synonym Protein Names   
Ig-alpha; MB-1 membrane glycoprotein; Membrane-bound immunoglobulin-associated protein; Surface IgM-associated protein
 Protein Family    B-cell antigen receptor complex-associated protein
 UniProt Gene Name    CD79A [Similar Products]
 UniProt Synonym Gene Names    IGA; MB1 [Similar Products]
 UniProt Entry Name    CD79A_HUMAN
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 NCBI Summary for CD79a    The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-alpha protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq]
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 UniProt Comments for CD79a    Function: Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also interacts with and increases activity of some Src-family tyrosine kinases. Represses BCR signaling during development of immature B cells. Ref.13 Ref.14

Subunit structure: Heterodimer of alpha and beta chains; disulfide-linked. Part of the B-cell antigen receptor complex where the alpha/beta chain heterodimer is non-covalently associated with an antigen-specific membrane-bound surface immunoglobulin of two heavy chains and two light chains. Interacts through its phosphorylated ITAM domain with the SH2 domains of SYK which stimulates SYK autophosphorylation and activation. Also interacts, when phosphorylated on Tyr-210, with the SH2 domain of BLNK/SLP65, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK which is necessary for trafficking of the BCR to late endosomes. Interacts with Src-family tyrosine kinases including FYN and LYN, increasing their activity

Subcellular location: Cell membrane; Single-pass type I membrane protein. Note: Following antigen binding, the BCR has been shown to translocate from detergent-soluble regions of the cell membrane to lipid rafts although signal transduction through the complex can also occur outside lipid rafts

Tissue specificity: B-cells.

Post-translational modification: Phosphorylated on tyrosine, serine and threonine residues upon B-cell activation. Phosphorylation of tyrosine residues by Src-family kinases is an early and essential feature of the BCR signaling cascade. The phosphorylated tyrosines serve as docking sites for SH2-domain containing kinases, leading to their activation which in turn leads to phosphorylation of downstream targets. Phosphorylation of serine and threonine residues may prevent subsequent tyrosine phosphorylation. Ref.16

Involvement in disease: Defects in CD79A are the cause of agammaglobulinemia type 3 (AGM3) [

MIM:613501]. It is a primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B cells due to an early block of B-cell development. Affected individuals develop severe infections in the first years of life. Note=Two different mutations, one at the splice donor site of intron 2 and the other at the splice acceptor site for exon 3, have been identified. Both mutations give rise to a truncated protein. Ref.15 Ref.17

Sequence similarities: Contains 1 Ig-like C2-type (immunoglobulin-like) domain.Contains 1 ITAM domain.
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 Research Articles on CD79a    1. STN produced significant antitumor effects in a mouse xenograft model of CD79A/B-mutated DLBCL.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CD79a antibodyPathways associated with anti-CD79a antibody
 Reference Product  PubMed Publications
 CD79B antibody  >521 publications with CD79a and CD79B
 CD5 antibody  >132 publications with CD79a and CD5
 CD19 antibody  >114 publications with CD79a and CD19
 Products by Pathway  Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 BCR Signaling Pathway antibodies  BCR Signaling Pathway Diagram
 Primary Immunodeficiency Pathway antibodies  Primary Immunodeficiency Pathway Diagram
 Primary Immunodeficiency Pathway antibodies  Primary Immunodeficiency Pathway Diagram
Diseases associated with anti-CD79a antibodyOrgans/Tissues associated with anti-CD79a antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >646 publications with CD79a and Neoplasms
 Lymphoma Antibodies  >546 publications with CD79a and Lymphoma
 Lymphoma, B-Cell Antibodies  >427 publications with CD79a and Lymphoma, B-Cell
 Leukemia, Myeloid, Acute Antibodies  >71 publications with CD79a and Leukemia, Myeloid, Acute
 Skin Neoplasms Antibodies  >66 publications with CD79a and Skin Neoplasms
 Neoplasms, Experimental Antibodies  >62 publications with CD79a and Neoplasms, Experimental
 Intestinal Diseases Antibodies  >37 publications with CD79a and Intestinal Diseases
 Leukemia-Lymphoma, Adult T-Cell Antibodies  >34 publications with CD79a and Leukemia-Lymphoma, Adult T-Cell
 Intestinal Neoplasms Antibodies  >33 publications with CD79a and Intestinal Neoplasms
 Liver Diseases Antibodies  >33 publications with CD79a and Liver Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >472 publications with CD79a and Blood
 Lymph Node Antibodies  >179 publications with CD79a and Lymph Node
 Lymph Antibodies  >169 publications with CD79a and Lymph
 Spleen Antibodies  >74 publications with CD79a and Spleen
 Liver Antibodies  >64 publications with CD79a and Liver
 Lung Antibodies  >44 publications with CD79a and Lung
 Intestine Antibodies  >34 publications with CD79a and Intestine
 Thymus Antibodies  >29 publications with CD79a and Thymus
 Mouth Antibodies  >19 publications with CD79a and Mouth
 Heart Antibodies  >17 publications with CD79a and Heart
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