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anti-CD8 ALPHA antibody :: Rat CD8 ALPHA Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS213859
Unit / Price
100 Tests  /  $230 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD8 ALPHA, Monoclonal Antibody

 Also Known As   

RAT ANTI MOUSE CD8 ALPHA:RPE

 Product Gene Name   

anti-CD8 ALPHA antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Clonality    Monoclonal
 Isotype    IgG2a
 Clone Number    KT15
 Host    Rat
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 Form/Format    Purified IgG conjugated to R. Phycoerythrin (RPE) - lyophilised
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 Reconstitution    Reconstitute with 1 ml distilled water
Perservative Stabilisers
 Buffer Solution    Phosphate buffered saline
 Target Species    Mouse
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 Preparation and Storage    Prior to reconstitution store at 4 degree C. Following reconstitution store at 4 degree C. This product should be stored undiluted. DO NOT FREEZE. This product is photosensitive and should be protected from light. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of reconstitution.
 Other Notes    Small volumes of anti-CD8 ALPHA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-CD8 ALPHA antibody   

Flow cytometry (FC/FACS)

 Application Notes for anti-CD8 ALPHA antibody    Flow Cytometry: Use 10ul of the suggested working dilution to label 106 cells in 100ul. The Fc region of monoclonal antibodies may bind non-specifically to cells expressing low affinity Fc receptors. This may be reduced by using SeroBlock FcR.
Flow Cytometry: Minimum Dilution: Neat; Maximum Dilution: 1/10
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 Testing Data of anti-CD8 ALPHA antibody    Staining of mouse spleen cells with Rat anti Mouse CD8 (MBS213104)
anti-CD8 ALPHA antibody Testing Data image
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 Testing Data of anti-CD8 ALPHA antibody    Immunoperoxidase staining of mouse lymph node cryosection stained with Rat antii Mouse CD8alpha antibody, clone KT15 followed by horseradish peroxidase conjugatedGoat anti Rat IgG (MBS235195) s a detection reagent. Low power
anti-CD8 ALPHA antibody Testing Data image
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 Testing Data of anti-CD8 ALPHA antibody    Staining of mouse spleen with Rat anti Mouse CD8 Alpha: RPE (MBS213860)
anti-CD8 ALPHA antibody Testing Data image
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 Testing Data of anti-CD8 ALPHA antibody    Staining of mouse spleen cells with Rat anti Mouse CD8 Alpha:RPE
anti-CD8 ALPHA antibody Testing Data image
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 Testing Data of anti-CD8 ALPHA antibody    Staining of mouse spleen with Rat anti Mouse CD8 Alpha: RPE - Alexa Fluor 647
anti-CD8 ALPHA antibody Testing Data image
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 Testing Data of anti-CD8 ALPHA antibody    Staining of mouse spleen cells with Rat anti Mouse CD8 Alpha: Biotin (MBS210507)
anti-CD8 ALPHA antibody Testing Data image
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 Testing Data of anti-CD8 ALPHA antibody    Immunoperoxidase staining of mouse lymph node cryosection stained with Rat antii Mouse CD8alpha antibody, clone KT15 followed by horseradish peroxidase conjugatedGoat anti Rat IgG (MBS235195) s a detection reagent. Medium power
anti-CD8 ALPHA antibody Testing Data image
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 Testing Data of anti-CD8 ALPHA antibody    Staining of mouse spleen with Rat anti Mouse CD8 Alpha: FITC (MBS211064)
anti-CD8 ALPHA antibody Testing Data image
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 Testing Data of anti-CD8 ALPHA antibody    Staining of mouse peripheral blood lymphocytes with Rat anti Mouse CD8 Alpha: Alexa Fluor 488
anti-CD8 ALPHA antibody Testing Data image
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 Testing Data of anti-CD8 ALPHA antibody    Immunoperoxidase staining of mouse lymph node cryosection stained with Rat antii Mouse CD8alpha antibody, clone KT15 followed by horseradish peroxidase conjugatedGoat anti Rat IgG (MBS235195) s a detection reagent. High power
anti-CD8 ALPHA antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for CD8 ALPHA. It may not necessarily be applicable to this product.
 NCBI GI #    124487437
 NCBI GeneID    12525
 NCBI Accession #    NP_001074579.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001081110.2 [Other Products]
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 UniProt Related Accession #    P01731 [Other Products]
 Molecular Weight    27,456 Da
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 NCBI Official Full Name    T-cell surface glycoprotein CD8 alpha chain isoform 1
 NCBI Official Synonym Full Names    CD8 antigen, alpha chain
 NCBI Official Symbol    Cd8a [Similar Products]
 NCBI Official Synonym Symbols   
Ly-2; Ly-B; Ly-35; Lyt-2; BB154331
[Similar Products]
 NCBI Protein Information    T-cell surface glycoprotein CD8 alpha chain; Lyt-2.1 lymphocyte differentiation antigen (AA at 100); T-cell surface glycoprotein Lyt-2
 UniProt Protein Name    T-cell surface glycoprotein CD8 alpha chain
 UniProt Synonym Protein Names   
T-cell surface glycoprotein Lyt-2; CD_antigen: CD8a
 UniProt Gene Name    Cd8a [Similar Products]
 UniProt Synonym Gene Names    Lyt-2; Lyt2 [Similar Products]
 UniProt Entry Name    CD8A_MOUSE
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 UniProt Comments for CD8 ALPHA    CD8A: Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains. In general heterodimer of an alpha and a beta chain linked by two disulfide bonds. Can also form homodimers. Shown to be expressed as heterodimer on thymocytes and as homodimer on peripheral blood T-lymphocytes. Interacts with the MHC class I HLA-A/B2M dimer. Interacts with LCK in a zinc-dependent manner. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Cellular Component: cell surface; membrane; integral to membrane; external side of plasma membrane

Molecular Function: protein binding; protein homodimerization activity; protein kinase binding

Biological Process: cell surface receptor linked signal transduction; T cell activation; immune system process; T cell mediated immunity; positive regulation of calcium-mediated signaling; cytotoxic T cell differentiation; defense response to virus
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 Research Articles on CD8 ALPHA    1. CD8alpha DCs, rather than CD8 T cells, are responsible for enhanced viral latency and recurrences.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-CD8 ALPHA antibodyDiseases associated with anti-CD8 ALPHA antibody
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway antibodies  Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway Diagram
 Primary Immunodeficiency Pathway antibodies  Primary Immunodeficiency Pathway Diagram
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >19 publications with CD8 ALPHA and Inflammation
 Necrosis Antibodies  >12 publications with CD8 ALPHA and Necrosis
 Cardiovascular Diseases Antibodies  >9 publications with CD8 ALPHA and Cardiovascular Diseases
 Neoplasms, Experimental Antibodies  >8 publications with CD8 ALPHA and Neoplasms, Experimental
 Carcinoma Antibodies  >7 publications with CD8 ALPHA and Carcinoma
 Liver Diseases Antibodies  >7 publications with CD8 ALPHA and Liver Diseases
 Kidney Diseases Antibodies  >5 publications with CD8 ALPHA and Kidney Diseases
 Fibrosis Antibodies  >4 publications with CD8 ALPHA and Fibrosis
 Liver Neoplasms Antibodies  >3 publications with CD8 ALPHA and Liver Neoplasms
 Heart Diseases Antibodies  >3 publications with CD8 ALPHA and Heart Diseases
Organs/Tissues associated with anti-CD8 ALPHA antibody
 Organ/Tissue Name  Pubmed Publications
 Spleen Antibodies  >26 publications with CD8 ALPHA and Spleen
 Thymus Antibodies  >15 publications with CD8 ALPHA and Thymus
 Bone Marrow Antibodies  >12 publications with CD8 ALPHA and Bone Marrow
 Thyroid Antibodies  >3 publications with CD8 ALPHA and Thyroid
 Embryonic Tissue Antibodies  >2 publications with CD8 ALPHA and Embryonic Tissue
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