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anti-cd8a antibody :: Mouse anti-Chicken CD8 alpha Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS673975 anti-cd8a antibody
Unit / Price
0.5 mg  /  $410 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD8 alpha (cd8a), Monoclonal Antibody

 Also Known As   

Mouse Anti-Chicken CD8a-FITC

 Product Synonym Names    Mouse Anti-Chicken CD8a - FITC; Mouse Anti-Chicken CD8 alpha
 Product Gene Name   

anti-cd8a antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 21; NC_007132.5 (9984191..9987415)
 3D Structure    ModBase 3D Structure for Q24JW8
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 Clonality    Monoclonal
 Isotype    IgG2b kappa
 Clone Number    3-298
 Host    Mouse
 Species Reactivity    Chicken
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 Specificity    alpha chain of chicken CD8 (Mr 34 kDa)
In the chicken, the CD8 molecule is present in two forms: (i) a homodimer of two alpha chains, and (ii) a heterodimer of an alpha chain and a beta chain.1,2 Chicken CD8 is expressed on approximately 80% of thymocytes, 45% of blood mononuclear cells and 50% of spleen cells, but <1% of cells in the bursa and bone marrow.1 While the vast majority of CD8+ cells in the thymus, spleen, and blood of adult chickens express both CD8 alpha - and CD8 beta -chains, a relatively large proportion of the CD8+ TCR- gamma delta cells in the spleens of embryos and young chicks express only the alpha -chain of CD8. Among intestinal epithelial lymphocytes, the major CD8+ T cell populations present in mice are conserved, but there is a population of TCR- gamma delta CD8 alpha beta cells in the chicken that is not found in rodents.3 MAb 3-298 recognizes the CD8 alpha chain of both the chicken and turkey.4
 Form/Format    Fluorescein (FITC) Conjugate
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 Characterization    To ensure optimal performance, each batch of monoclonal antibody is tested by flow cytometry to conform to characteristics of a standard reference reagent.
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 Preparation and Storage    The purified (UNLB) antibody is supplied as 0.5 mg of purified immunoglobulin in 1.0 mL of 100 mM borate buffered saline, pH 8.2. No preservatives or amine-containing buffer salts added. Store at 2- 8 degree C.
The fluorescein (FITC) conjugate is supplied as 0.5 mg in 1.0 mL of PBS/NaN3. Store at 2-8 degree C.
The biotin (BIOT) conjugate is supplied as 0.5 mg in 1.0 mL of PBS/NaN3. Store at 2-8 degree C.
The R-phycoerythrin (R-PE) conjugate is supplied as 0.1 mg in 1.0 mL of PBS/NaN3 and a stabilizing agent. Store at 2-8 degree C. Do not freeze!
The Cyanine 5 (CY 5) conjugate is supplied as 0.1 mg in 1.0 mL of PBS/NaN3. Store at 2-8 degree C.
Protect conjugated forms from light. Each reagent is stable for the period shown on the bottle label if stored as directed.
 Other Notes    Small volumes of anti-cd8a antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-cd8a antibody   

Flow Cytometry; Immunohistochemistry (Acetone Fixed/Frozen Sections); Immunoprecipitation

 Application Notes for anti-cd8a antibody    Research Application(s): Purification of CD8+ T cells by positive cell sorting

Flow Cytometry Suggested Dilution: <=1 ug/10^6 cells
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NCBI/Uniprot data below describe general gene information for cd8a. It may not necessarily be applicable to this product.
 NCBI GI #    91176308
 NCBI GeneID    677754
 NCBI Accession #    NP_001035138.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001040049.1 [Other Products]
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 UniProt Primary Accession #    Q24JW8 [Other Products]
 UniProt Related Accession #    Q24JW8; Q5H7M0 [Other Products]
 Molecular Weight    24,017 Da [Similar Products]
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 NCBI Official Full Name    CD8 antigen, alpha polypeptide
 NCBI Official Synonym Full Names    CD8 antigen, alpha polypeptide
 NCBI Official Symbol    cd8a [Similar Products]
 NCBI Official Synonym Symbols   
MGC136643; zgc:136643
[Similar Products]
 NCBI Protein Information    CD8 antigen, alpha polypeptide; CD8 alpha
 UniProt Protein Name    CD8 antigen, alpha polypeptide
 Protein Family    T-cell surface glycoprotein
 UniProt Gene Name    cd8a [Similar Products]
 UniProt Entry Name    Q24JW8_DANRE
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Product References and Citations for anti-cd8a antibody

   1. Chan, M.L., C.-L. Chen, L. Ager, and M.D. Cooper. 1988. J. Immunol. 140:2133-2138.
2. Cooper, M.D., R.P. Bucy, and C.-L. Chen. 1990. In: The Avian Model in Developmental Biology: From Organism to Genes. Editions du CNRS, pp. 239-249.
3. Tregaskes, C.A., F. Kong, E. Paramithiotis, C.-L. Chen, M.J.H. Ratcliffe, T. F. Davison, and J.R. Young. 1995. J. Immunol. 154:4485-4494.
4. Li, Z., K.E. Nestor, Y.M. Saif, Z. Fan, M. Luhtala, and O. Vainio. 1999. Poult Sci. 78:1526-1531.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Diseases associated with anti-cd8a antibodyOrgans/Tissues associated with anti-cd8a antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >14 publications with cd8a and Neoplasms
 Inflammation Antibodies  >13 publications with cd8a and Inflammation
 Cardiovascular Diseases Antibodies  >7 publications with cd8a and Cardiovascular Diseases
 Carcinoma Antibodies  >4 publications with cd8a and Carcinoma
 Liver Diseases Antibodies  >4 publications with cd8a and Liver Diseases
 Arthritis, Rheumatoid Antibodies  >4 publications with cd8a and Arthritis, Rheumatoid
 Kidney Diseases Antibodies  >4 publications with cd8a and Kidney Diseases
 Hemorrhage Antibodies  >3 publications with cd8a and Hemorrhage
 Heart Diseases Antibodies  >3 publications with cd8a and Heart Diseases
 Stroke Antibodies  >3 publications with cd8a and Stroke
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >8 publications with cd8a and Brain
 Whole Body Antibodies  >2 publications with cd8a and Whole Body
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