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anti-CD8 antibody :: Rat CD8 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS212306
Unit / Price
0.25 mg  /  $320 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD8, Monoclonal Antibody

★Popular Item★
 Also Known As   

RAT ANTI MOUSE CD8

 Product Gene Name   

anti-CD8 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Clonality    Monoclonal
 Isotype    IgG2b
 Clone Number    YTS169.4
 Host    Rat
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 Form/Format    Purified
Purified IgG - liquid
 Concentration    IgG concentration 1.0 mg/ml (lot specific)
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 Perservative Stabilisers    0.09% Sodium Azide
 Preparation    Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
 Buffer Solution    Phosphate buffered saline
 Target Species    Mouse
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 Preparation and Storage    Store at 4 degree C or at -20 degree C if preferred. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
 Other Notes    Small volumes of anti-CD8 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CD8 antibody

   Rat anti Mouse CD8 antibody, clone YTS169.4 recognizes the murine CD8 cell surface antigen, expressed by a subset of T lymphocytes. Rat anti Mouse CD8 antibody, clone YTS169.4 exhibits depleting activity when used in vivo.
 Applications Tested/Suitable for anti-CD8 antibody   

Immunohistology Frozen, Flow cytometry (FC/FACS)

 Application Notes for anti-CD8 antibody    Flow Cytometry: Use 10ul of the suggested working dilution to label 10^6 cells in 100ul.
Flow Cytometry: Minimum Dilution: 1/50; Maximum Dilution: 1/100
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 Testing Data of anti-CD8 antibody    Staining of mouse spleen cells with Rat anti Mouse CD8 Alpha: Azide Free (MBS210176)
anti-CD8 antibody Testing Data image
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 Testing Data of anti-CD8 antibody    Immunoperoxidase staining of a mouse lymph node cryosection with Rat anti Mouse CD8 antibody, clone YTS169.4 followed by horseradish peroxidase conjugated Goat anti Rat IgG antibody (MBS235195). Medium power
anti-CD8 antibody Testing Data image
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 Testing Data of anti-CD8 antibody    Staining of mouse spleen with Rat anti Mouse CD8 Alpha: RPE (MBS213666)
anti-CD8 antibody Testing Data image
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 Testing Data of anti-CD8 antibody    Immunoperoxidase staining of a mouse lymph node cryosection with Rat anti Mouse CD8 antibody, clone YTS169.4 followed by horseradish peroxidase conjugated Goat anti Rat IgG antibody (MBS235195). High power
anti-CD8 antibody Testing Data image
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 Testing Data of anti-CD8 antibody    Immunoperoxidase staining of a mouse lymph node cryosection with Rat anti Mouse CD8 antibody, clone YTS169.4 followed by horseradish peroxidase conjugated Goat anti Rat IgG antibody (MBS235195). Low power
anti-CD8 antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for CD8. It may not necessarily be applicable to this product.
 NCBI GI #    124487437
 NCBI GeneID    12525
 NCBI Accession #    NP_001074579.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001081110.2 [Other Products]
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 UniProt Related Accession #    P01731 [Other Products]
 Molecular Weight    27,456 Da
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 NCBI Official Full Name    T-cell surface glycoprotein CD8 alpha chain isoform 1
 NCBI Official Synonym Full Names    CD8 antigen, alpha chain
 NCBI Official Symbol    Cd8a [Similar Products]
 NCBI Official Synonym Symbols   
Ly-2; Ly-B; Ly-35; Lyt-2; BB154331
[Similar Products]
 NCBI Protein Information    T-cell surface glycoprotein CD8 alpha chain; Lyt-2.1 lymphocyte differentiation antigen (AA at 100); T-cell surface glycoprotein Lyt-2
 UniProt Protein Name    T-cell surface glycoprotein CD8 alpha chain
 UniProt Synonym Protein Names   
T-cell surface glycoprotein Lyt-2; CD_antigen: CD8a
 Protein Family    CD81 antigen
 UniProt Gene Name    Cd8a [Similar Products]
 UniProt Synonym Gene Names    Lyt-2; Lyt2 [Similar Products]
 UniProt Entry Name    CD8A_MOUSE
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 UniProt Comments for CD8    CD8A: Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains. In general heterodimer of an alpha and a beta chain linked by two disulfide bonds. Can also form homodimers. Shown to be expressed as heterodimer on thymocytes and as homodimer on peripheral blood T-lymphocytes. Interacts with the MHC class I HLA-A/B2M dimer. Interacts with LCK in a zinc-dependent manner. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Cellular Component: cell surface; membrane; integral to membrane; external side of plasma membrane

Molecular Function: protein binding; protein homodimerization activity; protein kinase binding

Biological Process: cell surface receptor linked signal transduction; T cell activation; immune system process; T cell mediated immunity; positive regulation of calcium-mediated signaling; cytotoxic T cell differentiation; defense response to virus
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 Research Articles on CD8    1. CD8alpha DCs, rather than CD8 T cells, are responsible for enhanced viral latency and recurrences.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-CD8 antibodyDiseases associated with anti-CD8 antibody
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway antibodies  Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway Diagram
 Primary Immunodeficiency Pathway antibodies  Primary Immunodeficiency Pathway Diagram
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >19 publications with CD8 and Inflammation
 Necrosis Antibodies  >12 publications with CD8 and Necrosis
 Cardiovascular Diseases Antibodies  >9 publications with CD8 and Cardiovascular Diseases
 Neoplasms, Experimental Antibodies  >8 publications with CD8 and Neoplasms, Experimental
 Carcinoma Antibodies  >7 publications with CD8 and Carcinoma
 Liver Diseases Antibodies  >7 publications with CD8 and Liver Diseases
 Kidney Diseases Antibodies  >5 publications with CD8 and Kidney Diseases
 Fibrosis Antibodies  >4 publications with CD8 and Fibrosis
 Liver Neoplasms Antibodies  >3 publications with CD8 and Liver Neoplasms
 Heart Diseases Antibodies  >3 publications with CD8 and Heart Diseases
Organs/Tissues associated with anti-CD8 antibody
 Organ/Tissue Name  Pubmed Publications
 Spleen Antibodies  >26 publications with CD8 and Spleen
 Thymus Antibodies  >15 publications with CD8 and Thymus
 Bone Marrow Antibodies  >12 publications with CD8 and Bone Marrow
 Thyroid Antibodies  >3 publications with CD8 and Thyroid
 Embryonic Tissue Antibodies  >2 publications with CD8 and Embryonic Tissue
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