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anti-CD8 antibody :: Mouse anti-Cat (Cat) CD8 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS532699 anti-CD8 antibody
Unit / Price
0.5 mg  /  $625 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD8, Monoclonal Antibody

 Also Known As   

CD8 antibody (FITC)

 Product Synonym Names    Monoclonal CD8; Anti-CD8; CD-8; CD8; CD 8
 Product Gene Name   

anti-CD8 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    186730
 3D Structure    ModBase 3D Structure for P10966
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    FCD8
 Host    Mouse
 Species Reactivity    Cat (Cat)
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 Form/Format    Supplied as a liquid in PBS, with NaN3 added as preservative.
 Concentration    0.5 mg/ml (lot specific)
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 Biological Significance    CD8 (cluster of differentiation 8) is a transmembrane glycoprotein that serves as a co-receptor for the T cell receptor (TCR). Like the TCR, CD8 binds to a major histocompatibility complex (MHC) molecule, but is specific for the class I MHC protein. There are two isoforms of the protein, alpha and beta, each encoded by a different gene.
 Biohazard Information    This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product.
 Tag/Conjugate    FITC
 Immunogen    CD8 antibody (FITC) was raised in mouse using feline CD8 as the immunogen.
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 Preparation and Storage    Store at 4 degree C.
 Other Notes    Small volumes of anti-CD8 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CD8 antibody

   Mouse monoclonal CD8 antibody (FITC)
 Product Categories/Family for anti-CD8 antibody    Immunology; Conjugated Monoclonal Antibodies
 Applications Tested/Suitable for anti-CD8 antibody   

Flow Cytometry (FC/FACS), Immunohistochemistry (IHC)

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NCBI/Uniprot data below describe general gene information for CD8. It may not necessarily be applicable to this product.
 NCBI GI #    178673
 NCBI GeneID    926
 NCBI Accession #    AAA52283.1 [Other Products]
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 UniProt Primary Accession #    P10966 [Other Products]
 UniProt Secondary Accession #    P14860; P14861; Q15980; Q496E0; Q496E1; Q496E2; Q9UDB4; Q9UDB5; Q9UDB6; Q9UDB7; Q9UDB8 [Other Products]
 UniProt Related Accession #    P10966 [Other Products]
 Molecular Weight    22,237 Da
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 NCBI Official Full Name    CD8 antigen, partial
 NCBI Official Synonym Full Names    CD8b molecule
 NCBI Official Symbol    CD8B [Similar Products]
 NCBI Official Synonym Symbols   
LY3; P37; LEU2; LYT3; CD8B1
[Similar Products]
 NCBI Protein Information    T-cell surface glycoprotein CD8 beta chain
 UniProt Protein Name    T-cell surface glycoprotein CD8 beta chain
 UniProt Synonym Protein Names   
CD_antigen: CD8b
 Protein Family    CD81 antigen
 UniProt Gene Name    CD8B [Similar Products]
 UniProt Synonym Gene Names    CD8B1 [Similar Products]
 UniProt Entry Name    CD8B_HUMAN
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 NCBI Summary for CD8    The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigens displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 beta chain isoforms. Multiple alternatively spliced transcript variants encoding distinct membrane associated or secreted isoforms have been described. A pseudogene, also located on chromosome 2, has been identified. [provided by RefSeq, May 2010]
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 UniProt Comments for CD8    CD8B: Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. 8 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 2p12

Cellular Component: T cell receptor complex; integral to plasma membrane; early endosome membrane; extracellular region; plasma membrane; external side of plasma membrane

Molecular Function: protein binding; MHC class I protein binding; coreceptor activity

Biological Process: regulation of immune response; T cell activation; viral reproduction; immune response; regulation of defense response to virus by virus; transmembrane receptor protein tyrosine kinase signaling pathway
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 Research Articles on CD8    1. CREMalpha orchestrates epigenetic remodeling of the CD8A,B through the recruitment of DNA methyltransferase (DNMT) 3a and histone methyltransferase G9a.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-CD8 antibodyDiseases associated with anti-CD8 antibody
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Downstream Signaling In Naive CD8+ T Cells Pathway antibodies  Downstream Signaling In Naive CD8+ T Cells Pathway Diagram
 HIV Infection Pathway antibodies  HIV Infection Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Disease Name  Pubmed Publications
 Sepsis Antibodies  >1 publications with CD8 and Sepsis
 Chromosome Aberrations Antibodies  >1 publications with CD8 and Chromosome Aberrations
 Hemorrhage Antibodies  >1 publications with CD8 and Hemorrhage
 Liver Diseases Antibodies  >1 publications with CD8 and Liver Diseases
 Necrosis Antibodies  >1 publications with CD8 and Necrosis
Organs/Tissues associated with anti-CD8 antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >29 publications with CD8 and Blood
 Thymus Antibodies  >6 publications with CD8 and Thymus
 Lymph Node Antibodies  >4 publications with CD8 and Lymph Node
 Trachea Antibodies  >2 publications with CD8 and Trachea
 Intestine Antibodies  >1 publications with CD8 and Intestine
 Lung Antibodies  >1 publications with CD8 and Lung
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