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anti-CD80/B7-1 antibody :: Mouse anti-Human  CD80/B7-1 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS850955
Testing Data
Unit / Price
0.1 mL  /  $290 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD80/B7-1, Monoclonal Antibody

 Also Known As   

CD80/B7-1 Antibody

 Product Gene Name   

anti-CD80/B7-1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    112203
 3D Structure    ModBase 3D Structure for P33681
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 Clonality    Monoclonal
 Clone Number    8-E5
 Host    Mouse
 Species Reactivity    Human 
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 Specificity    This antibody is produced by immunizing mouse with a synthetic peptide (KLH-coupled) corresponding to CD80.
 Form/Format    Mouse monoclonal IgG2b in 1*TBS (pH7.4), 0.5%BSA, 25%Glycerol. Preservative: 0.05% Sodium Azide.
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 Cellular Localization    Cell membrane
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 Preparation and Storage    Store at 4 degree C after thawing. Aliquot store at -20 degree C or -80 degree C. Avoid repeated freeze / thaw cycles.
 Other Notes    Small volumes of anti-CD80/B7-1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-CD80/B7-1 antibody

   Background: B7-1 is a molecule found on activated B cells and monocytes which provides a costimulatory signal necessary for T cell activation and survival. After engagement of T-cell receptor with antigen in association with major histocompatibility complex class II, a second signal mediated through the binding of B7 to CD28 greatly upregulates the production of multiple lymphokines. B7-1 is a costimulatory molecule for the activation of both CD4+ and CD8+ T lymphocytes that prevents the induction of clonal anergy. Thus, the transfer of B7-1 genes into tumor cells can induce protective immunity and lead to tumor rejection of some tumors in model systems of in vivo tumor growth.
 Product Categories/Family for anti-CD80/B7-1 antibody    Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody
 Applications Tested/Suitable for anti-CD80/B7-1 antibody   

Western Blot (WB) 

 Application Notes for anti-CD80/B7-1 antibody    WB: 1:500
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 Testing Data of anti-CD80/B7-1 antibody    anti-CD80/B7-1 antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for CD80/B7-1. It may not necessarily be applicable to this product.
 NCBI GI #    4885123
 NCBI GeneID    941
 NCBI Accession #    NP_005182.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_005191.3 [Other Products]
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 UniProt Primary Accession #    P33681 [Other Products]
 UniProt Secondary Accession #    Q5DTA9; Q5DTB0 [Other Products]
 UniProt Related Accession #    P33681 [Other Products]
 Molecular Weight    ~60kDa
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 NCBI Official Full Name    T-lymphocyte activation antigen CD80
 NCBI Official Synonym Full Names    CD80 molecule
 NCBI Official Symbol    CD80 [Similar Products]
 NCBI Official Synonym Symbols   
B7; BB1; B7-1; B7.1; LAB7; CD28LG; CD28LG1
[Similar Products]
 NCBI Protein Information    T-lymphocyte activation antigen CD80; activation B7-1 antigen; costimulatory factor CD80; CTLA-4 counter-receptor B7.1; B-lymphocyte activation antigen B7; costimulatory molecule variant IgV-CD80; CD80 antigen (CD28 antigen ligand 1, B7-1 antigen)
 UniProt Protein Name    T-lymphocyte activation antigen CD80
 UniProt Synonym Protein Names   
Activation B7-1 antigen; BB1; CTLA-4 counter-receptor B7.1; B7; CD_antigen: CD80
 UniProt Gene Name    CD80 [Similar Products]
 UniProt Synonym Gene Names    CD28LG; CD28LG1; LAB7; B7 [Similar Products]
 UniProt Entry Name    CD80_HUMAN
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 NCBI Summary for CD80/B7-1    The protein encoded by this gene is a membrane receptor that is activated by the binding of CD28 or CTLA-4. The activated protein induces T-cell proliferation and cytokine production. This protein can act as a receptor for adenovirus subgroup B and may play a role in lupus neuropathy. [provided by RefSeq, Aug 2011]
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 UniProt Comments for CD80/B7-1    CD80: Involved in the costimulatory signal essential for T- lymphocyte activation. T-cell proliferation and cytokine production is induced by the binding of CD28 or CTLA-4 to this receptor.

Protein type: Membrane protein, integral; Immunoglobulin superfamily

Chromosomal Location of Human Ortholog: 3q13.3-q21

Cellular Component: cell surface; plasma membrane; integral to membrane; external side of plasma membrane

Molecular Function: protein binding; coreceptor activity

Biological Process: epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; phosphoinositide-mediated signaling; positive regulation of signal transduction; T cell activation; viral reproduction; nerve growth factor receptor signaling pathway; positive regulation of transcription, DNA-dependent; positive regulation of interleukin-2 biosynthetic process; positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process; positive regulation of peptidyl-tyrosine phosphorylation; cell-cell signaling; T cell costimulation; innate immune response; positive regulation of alpha-beta T cell proliferation; positive regulation of T-helper 1 cell differentiation
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Product References and Citations for anti-CD80/B7-1 antibody

   Freeman GJ, et al. Blood 79(2):489-94, 1992.
Stamper CC, et al. Nature 411(6837):617, 2001.
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 Research Articles on CD80/B7-1    1. Expression of costimulatory molecules CD80/86 is an absolute requirement for efficient CD8 T cell priming by adenoviral vectors.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CD80/B7-1 antibodyPathways associated with anti-CD80/B7-1 antibody
 Reference Product  PubMed Publications
 CD86 antibody  >4660 publications with CD80/B7-1 and CD86
 CD4 antibody  >2105 publications with CD80/B7-1 and CD4
 CD28 antibody  >1802 publications with CD80/B7-1 and CD28
 CTLA4 antibody  >1009 publications with CD80/B7-1 and CTLA4
 ICAM1 antibody  >415 publications with CD80/B7-1 and ICAM1
 PRF1 antibody  >62 publications with CD80/B7-1 and PRF1
 IFNG antibody  >6 publications with CD80/B7-1 and IFNG
 CSF2 antibody  >2 publications with CD80/B7-1 and CSF2
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Autoimmune Thyroid Disease Pathway antibodies  Autoimmune Thyroid Disease Pathway Diagram
 Autoimmune Thyroid Disease Pathway antibodies  Autoimmune Thyroid Disease Pathway Diagram
 CD28 Co-stimulation Pathway antibodies  CD28 Co-stimulation Pathway Diagram
 CD28 Dependent PI3K/Akt Signaling Pathway antibodies  CD28 Dependent PI3K/Akt Signaling Pathway Diagram
 CD28 Dependent Vav1 Pathway antibodies  CD28 Dependent Vav1 Pathway Diagram
 CTLA4 Inhibitory Signaling Pathway antibodies  CTLA4 Inhibitory Signaling Pathway Diagram
Diseases associated with anti-CD80/B7-1 antibodyOrgans/Tissues associated with anti-CD80/B7-1 antibody
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >1102 publications with CD80/B7-1 and Necrosis
 Inflammation Antibodies  >732 publications with CD80/B7-1 and Inflammation
 Neoplasms, Experimental Antibodies  >378 publications with CD80/B7-1 and Neoplasms, Experimental
 Nervous System Diseases Antibodies  >342 publications with CD80/B7-1 and Nervous System Diseases
 Lung Diseases Antibodies  >301 publications with CD80/B7-1 and Lung Diseases
 Liver Diseases Antibodies  >221 publications with CD80/B7-1 and Liver Diseases
 Kidney Diseases Antibodies  >149 publications with CD80/B7-1 and Kidney Diseases
 Lung Neoplasms Antibodies  >110 publications with CD80/B7-1 and Lung Neoplasms
 Neoplasm Metastasis Antibodies  >81 publications with CD80/B7-1 and Neoplasm Metastasis
 Breast Neoplasms Antibodies  >80 publications with CD80/B7-1 and Breast Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >5879 publications with CD80/B7-1 and Blood
 Lymph Node Antibodies  >576 publications with CD80/B7-1 and Lymph Node
 Lung Antibodies  >414 publications with CD80/B7-1 and Lung
 Thymus Antibodies  >177 publications with CD80/B7-1 and Thymus
 Tonsil Antibodies  >39 publications with CD80/B7-1 and Tonsil
 Connective Tissue Antibodies  >33 publications with CD80/B7-1 and Connective Tissue
 Mammary Gland Antibodies  >4 publications with CD80/B7-1 and Mammary Gland
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