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anti-LOC554318 antibody :: Rat anti-Mouse CD86/B7-2 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS673702
Testing Data
Unit / Price
0.5 mg  /  $295 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD86/B7-2 (LOC554318), Monoclonal Antibody

 Also Known As   

Rat Anti-Mouse CD86/B7-2-FITC

 Product Synonym Names    Rat Anti-Mouse CD86/B7-2 - FITC; Rat Anti-Mouse CD86/B7-2
 Product Gene Name   

anti-LOC554318 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Clonality    Monoclonal
 Isotype    Rat IgG2b kappa
 Clone Number    2D10
 Host    Rat
 Species Reactivity    Mouse
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 Specificity    Mouse CD86, the B7-2 costimulatory molecule and a ligand for CD28 and CD152
CD86/B7-2 is an 80 kDa type I integral membrane protein and a member of the immunoglobulin superfamily of cell surface receptors. Along with CD80/B7-1, CD86 participates in T cell costimulation via interaction with CD28 and CD152/CTLA-4. It is expressed at very low density in normal tissues but is rapidly upregulated on stimulated B cells, monocytes and dendritic cells. Since CD86/B7-2 has rapid kinetics of induction, it is believed to be the major CD28 ligand expressed early in the immune response.1-9
 Form/Format    Fluorescein (FITC) Conjugate
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 Characterization    To ensure lot-to-lot consistency, each batch of monoclonal antibody is tested by flow cytometry to conform to characteristics of a standard reference reagent. Representative data are included in this product insert.
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 Preparation and Storage    The purified (UNLB) antibody is supplied as 0.5 mg of purified immunoglobulin in 1.0 mL of 100 mM borate buffered saline, pH 8.2. No preservatives or amine-containing buffer salts added. Store at 2-8 degree C.
The fluorescein (FITC) conjugate is supplied as 0.5 mg in 1.0 mL of PBS/NaN3. Store at 2-8 degree C.
The biotin (BIOT) conjugate is supplied as 0.5 mg in 1.0 mL of PBS/NaN3. Store at 2-8 degree C.
The R-phycoerythrin (R-PE) conjugate is supplied as 0.1 mg in 1.0 mL of PBS/NaN3 and a stabilizing agent. Store at 2-8 degree C. Do not freeze!
The allophycocyanin (APC) conjugate is supplied as 0.1 mg in 1.0 mL of PBS/NaN3 and a stabilizing agent. Store at 2-8 degree C. Do not freeze!
The Spectral Red (SPRD) and R-phycoerythrin-Cyanine 7 (R-PE-CY 7) conjugates are supplied as 0.1 mg in 1.0 mL of PBS/NaN3 and a stabilizing agent. Store at 2-8 degree C. Do not freeze!
The low endotoxin, azide-free (LE/AF) antibody is supplied as 0.5 mg purified immunoglobulin in 1.0 mL of PBS. Aliquot and store at or below -20 degree C.
Protect conjugated forms from light. Aliquot and freeze the low endotoxin, azide-free product at -20 degree C immediately upon receipt. Each reagent is stable for the period shown on the bottle label if stored as directed.
 Other Notes    Small volumes of anti-LOC554318 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-LOC554318 antibody   

Flow Cytometry; Immunohistochemistry (Frozen Sections); Immunoprecipitation

 Application Notes for anti-LOC554318 antibody    Research Application(s): Identification and enumeration of CD86+ cells by flow cytometry
Identification of CD86+ cells in frozen sections
In vivo and in vitro blocking assays

Flow Cytometry Suggested Dilution: <= 1 ug/10^6 cells
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 Testing Data of anti-LOC554318 antibody    anti-LOC554318 antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for LOC554318. It may not necessarily be applicable to this product.
 NCBI GI #    84000438
 NCBI GeneID    554318
 NCBI Accession #    NP_001033105.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001038016.1 [Other Products]
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 NCBI Official Full Name    CD86/B7-2 costimulatory molecule
 NCBI Official Symbol    LOC554318 [Similar Products]
 NCBI Protein Information    CD86/B7-2 costimulatory molecule; CD86 antigen; B7-1 costimulatory molecule
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Product References and Citations for anti-LOC554318 antibody

   1. Hathcock, K., G. Laszlo, C. Pucello, O. Linsley, anmd R.J. Hodes. 1994. J. Exp. Med. 180:631.
2. Freeman, G.J., F. Borriello, R.J. Hodes, H. Reiser, K.S. Hathcock, G. Laszlo, A.J. McKnight, J. Kim, L. Du, D.B. Lombard, G.S. Gray, L.M. Nadler, and A.H. Sharpe. 1993. Science 262:907.
3. Laszlo, G., K.S. Hathcock, H.B. Dickler, and R.J. Hodes. 1993. J. Immunol. 150:5252.
4. Hathcock, K., G. Laszlo, H. Dickler, J. Bradshaw, P. Linsley, and R Hodes. 1993. Science 262:905.
5. Thompson, C.B. 1995. Cell 978:979.
6. June, C.H., J.A. Bluestone, L.M. Nadler, and C.B. Thompson. 1994. Immuol. Today 15:321.
7. Han, S. et al. 1995. J. Immunol. 155:556.
8. Inaba, K. et al. 1994. J. Exp. Med. 180:1849.
9. Larsen, C.P., et al. 1994. J. Immunol. 152:5208.
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 Research Articles on LOC554318    1. decreased B7-1 (CD80) RNA levels and diminished antigen-specific cellular immune responses in PBMCs point to a Visna/Maedi virus disease status, whereas increased CD80 and CD86 levels and augmented cellular responses are linked to asymptomatic infection.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Organs/Tissues associated with anti-LOC554318 antibody
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >13 publications with LOC554318 and Bone
 Connective Tissue Antibodies  >4 publications with LOC554318 and Connective Tissue
 Heart Antibodies  >3 publications with LOC554318 and Heart
 Muscle Antibodies  >3 publications with LOC554318 and Muscle
 Brain Antibodies  >3 publications with LOC554318 and Brain
 Vascular Antibodies  >2 publications with LOC554318 and Vascular
 Embryonic Tissue Antibodies  >2 publications with LOC554318 and Embryonic Tissue
 Ear Antibodies  >1 publications with LOC554318 and Ear
 Kidney Antibodies  >1 publications with LOC554318 and Kidney
 Umbilical Cord Antibodies  >1 publications with LOC554318 and Umbilical Cord
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