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anti-CD86 antibody :: Rat CD86 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS210740 anti-CD86 antibody
Unit / Price
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 Product Name   

CD86, Monoclonal Antibody

 Also Known As   


 Product Gene Name   

anti-CD86 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for P42082
 Clonality    Monoclonal
 Isotype    IgG2a
 Clone Number    RMMP-2
 Host    Rat
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 Form/Format    FITC
Purified IgG conjugated to Fluorescein Isothiocyanate Isomer 1 (FITC) - liquid
 Concentration    IgG concentration 0.1 mg/ml (lot specific)
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 Perservative Stabilisers    0.09% Sodium Azide
1% Bovine Serum Albumin
 Buffer Solution    Phosphate buffered saline
 Target Species    Mouse
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 Preparation and Storage    Store at 4 degree C or at -20 degree C if preferred. This product should be stored undiluted. Storage in frost-free freezers is not recommended. This product is photosensitive and should be protected from light. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
 Other Notes    Small volumes of anti-CD86 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CD86 antibody

   Rat anti Mouse CD86 antibody, clone RMMP-2 recognizes the murine CD86 cell surface antigen, also known as B7-2.
 Applications Tested/Suitable for anti-CD86 antibody   

Flow cytometry (FC/FACS)

 Application Notes for anti-CD86 antibody    Flow Cytometry: Use 10ul of the suggested working dilution to label 106 cells in 100ul. The Fc region of monoclonal antibodies may bind non-specifically to cells expressing low affinity Fc receptors. This may be reduced by using SeroBlock FcR.
Flow Cytometry: Maximum Dilution: Neat
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NCBI/Uniprot data below describe general gene information for CD86. It may not necessarily be applicable to this product.
 NCBI GI #    161484599
 NCBI GeneID    12524
 NCBI Accession #    NP_062261.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_019388.3 [Other Products]
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 UniProt Primary Accession #    P42082 [Other Products]
 UniProt Related Accession #    P42082 [Other Products]
 Molecular Weight    33,962 Da
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 NCBI Official Full Name    T-lymphocyte activation antigen CD86
 NCBI Official Synonym Full Names    CD86 antigen
 NCBI Official Symbol    Cd86 [Similar Products]
 NCBI Official Synonym Symbols   
B7; B70; MB7; B7-2; B7.2; CLS1; Ly58; ETC-1; Ly-58; MB7-2; Cd28l2; TS/A-2
[Similar Products]
 NCBI Protein Information    T-lymphocyte activation antigen CD86; activation B7-2 antigen; early T cell costimulatory molecule-1; early T-cell costimulatory molecule 1
 UniProt Protein Name    T-lymphocyte activation antigen CD86
 UniProt Synonym Protein Names   
Activation B7-2 antigen; Early T-cell costimulatory molecule 1; ETC-1; CD_antigen: CD86
 Protein Family    T-lymphocyte activation antigen
 UniProt Gene Name    Cd86 [Similar Products]
 UniProt Synonym Gene Names    ETC-1 [Similar Products]
 UniProt Entry Name    CD86_MOUSE
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 UniProt Comments for CD86    CD86: Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T- cells within 24 hours after activation. Isoform 2 interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Immunoglobulin superfamily; Membrane protein, integral

Cellular Component: cell surface; membrane; intracellular membrane-bound organelle; integral to membrane; plasma membrane; external side of plasma membrane

Molecular Function: receptor binding

Biological Process: negative regulation of T cell anergy; B cell activation; immune system process; toll-like receptor signaling pathway; positive regulation of T cell proliferation; positive regulation of activated T cell proliferation; defense response to virus
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 Research Articles on CD86    1. data show an important role of the adaptive immune system, in particular T cell CD80/86 costimulation molecules, in the physiological regulation of bone resorption and preservation of bone mass
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-CD86 antibodyDiseases associated with anti-CD86 antibody
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Autoimmune Thyroid Disease Pathway antibodies  Autoimmune Thyroid Disease Pathway Diagram
 Autoimmune Thyroid Disease Pathway antibodies  Autoimmune Thyroid Disease Pathway Diagram
 CD28 Co-stimulation Pathway antibodies  CD28 Co-stimulation Pathway Diagram
 CD28 Dependent PI3K/Akt Signaling Pathway antibodies  CD28 Dependent PI3K/Akt Signaling Pathway Diagram
 CD28 Dependent Vav1 Pathway antibodies  CD28 Dependent Vav1 Pathway Diagram
 CTLA4 Inhibitory Signaling Pathway antibodies  CTLA4 Inhibitory Signaling Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >1159 publications with CD86 and Necrosis
 Inflammation Antibodies  >839 publications with CD86 and Inflammation
 Nervous System Diseases Antibodies  >287 publications with CD86 and Nervous System Diseases
 Lung Diseases Antibodies  >277 publications with CD86 and Lung Diseases
 Neoplasms, Experimental Antibodies  >210 publications with CD86 and Neoplasms, Experimental
 Liver Diseases Antibodies  >196 publications with CD86 and Liver Diseases
 Cardiovascular Diseases Antibodies  >184 publications with CD86 and Cardiovascular Diseases
 Brain Diseases Antibodies  >151 publications with CD86 and Brain Diseases
 Dermatitis, Contact Antibodies  >111 publications with CD86 and Dermatitis, Contact
 Kidney Diseases Antibodies  >90 publications with CD86 and Kidney Diseases
Organs/Tissues associated with anti-CD86 antibody
 Organ/Tissue Name  Pubmed Publications
 Bone Marrow Antibodies  >1070 publications with CD86 and Bone Marrow
 Spleen Antibodies  >693 publications with CD86 and Spleen
 Lymph Node Antibodies  >651 publications with CD86 and Lymph Node
 Skin Antibodies  >458 publications with CD86 and Skin
 Lung Antibodies  >359 publications with CD86 and Lung
 Liver Antibodies  >288 publications with CD86 and Liver
 Thymus Antibodies  >122 publications with CD86 and Thymus
 Uncharacterized Tissue Antibodies  >3 publications with CD86 and Uncharacterized Tissue
 Mammary Gland Antibodies  >1 publications with CD86 and Mammary Gland
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