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anti-CD86 antibody :: Rat anti-Murine CD86 CD86 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS531955 anti-CD86 antibody
Unit / Price
0.5 mg  /  $515 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD86, Monoclonal Antibody

 Also Known As   

CD86 antibody (Azide Free)

 Product Synonym Names    Monoclonal CD86; Anti-CD86; CD-86; CD 86; CD86; B72
 Product Gene Name   

anti-CD86 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    601020
 3D Structure    ModBase 3D Structure for P42081
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 Clonality    Monoclonal
 Isotype    IgG2a
 Clone Number    GL1
 Host    Rat
 Species Reactivity    Murine CD86
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 Form/Format    Supplied as a liquid in PBS.
 Concentration    0.5 mg/ml (lot specific)
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 Biological Significance    Cluster of Differentiation 86 (also known as CD86 and B7-2) is a protein expressed on antigen-presenting cells that provides costimulatory signals necessary for T cell activation and survival. It is the ligand for two different proteins on the T cell surface: CD28 (for autoregulation and intercellular association) and CTLA-4 (for attenuation of regulation and cellular disassociation). CD86 works in tandem with CD80 to prime T cells.
 Immunogen    CD86 antibody (Azide free) was raised in rat using LPS-activated murine B cells as the immunogen.
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 Preparation and Storage    Aliquot and store at -20 degree C. Avoid repeated freeze/thaw cycles
 Other Notes    Small volumes of anti-CD86 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CD86 antibody

   Rat monoclonal CD86 antibody (Azide Free)
 Product Categories/Family for anti-CD86 antibody    Immunology
 Applications Tested/Suitable for anti-CD86 antibody   

Flow Cytometry (FC/FACS), Immunohistochemistry (IHC)

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NCBI/Uniprot data below describe general gene information for CD86. It may not necessarily be applicable to this product.
 NCBI GI #    49456643
 NCBI GeneID    942
 NCBI Accession #    CAG46642.1 [Other Products]
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 UniProt Primary Accession #    P42081 [Other Products]
 UniProt Secondary Accession #    Q13655; Q6FHB1; Q6GTS4; Q7M4L5; A0N0P0; B7Z2F3; B7Z702; E7ETN5; E9PC27 [Other Products]
 UniProt Related Accession #    P42081 [Other Products]
 Molecular Weight    28,420 Da
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 NCBI Official Full Name    CD86, partial
 NCBI Official Synonym Full Names    CD86 molecule
 NCBI Official Symbol    CD86 [Similar Products]
 NCBI Official Synonym Symbols   
B70; B7-2; B7.2; LAB72; CD28LG2
[Similar Products]
 NCBI Protein Information    T-lymphocyte activation antigen CD86
 UniProt Protein Name    T-lymphocyte activation antigen CD86
 UniProt Synonym Protein Names   
Activation B7-2 antigen; B70; BU63; CTLA-4 counter-receptor B7.2; FUN-1; CD_antigen: CD86
 Protein Family    T-lymphocyte activation antigen
 UniProt Gene Name    CD86 [Similar Products]
 UniProt Synonym Gene Names    CD28LG2 [Similar Products]
 UniProt Entry Name    CD86_HUMAN
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 NCBI Summary for CD86    This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in several transcript variants encoding different isoforms.[provided by RefSeq, May 2011]
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 UniProt Comments for CD86    CD86: Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T- cells within 24 hours after activation. Isoform 2 interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Immunoglobulin superfamily; Membrane protein, integral

Chromosomal Location of Human Ortholog: 3q21

Cellular Component: cell surface; intracellular membrane-bound organelle; plasma membrane; integral to membrane; external side of plasma membrane

Molecular Function: protein binding; coreceptor activity; receptor activity; receptor binding

Biological Process: positive regulation of lymphotoxin A biosynthetic process; nerve growth factor receptor signaling pathway; T cell activation; negative regulation of T cell anergy; viral reproduction; positive regulation of interleukin-2 biosynthetic process; positive regulation of transcription, DNA-dependent; myeloid dendritic cell differentiation; positive regulation of activated T cell proliferation; positive regulation of interleukin-4 biosynthetic process; positive regulation of T-helper 2 cell differentiation; cell-cell signaling; T cell proliferation during immune response; positive regulation of cell proliferation; response to yeast; defense response to virus; aging; response to drug; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; phosphoinositide-mediated signaling; B cell activation; T cell costimulation; toll-like receptor signaling pathway; innate immune response; immune response
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 Research Articles on CD86    1. CD86 polymorphisms (rs1129055) may have protective effects on cancer risk in Asians and that CD86 polymorphisms (rs17281995) is likely to contribute to risk of cancer, particularly colorectal cancer in Caucasians.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CD86 antibodyPathways associated with anti-CD86 antibody
 Reference Product  PubMed Publications
 CD80 antibody  >4809 publications with CD86 and CD80
 CD40 antibody  >2371 publications with CD86 and CD40
 CD28 antibody  >1090 publications with CD86 and CD28
 CTLA4 antibody  >667 publications with CD86 and CTLA4
 HLA-A antibody  >72 publications with CD86 and HLA-A
 IFNG antibody  >7 publications with CD86 and IFNG
 ZAP70 antibody  >5 publications with CD86 and ZAP70
 GRB2 antibody  >4 publications with CD86 and GRB2
 CD8A antibody  >3 publications with CD86 and CD8A
 UBC antibody  >1 publications with CD86 and UBC
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Autoimmune Thyroid Disease Pathway antibodies  Autoimmune Thyroid Disease Pathway Diagram
 Autoimmune Thyroid Disease Pathway antibodies  Autoimmune Thyroid Disease Pathway Diagram
 CD28 Co-stimulation Pathway antibodies  CD28 Co-stimulation Pathway Diagram
 CD28 Dependent PI3K/Akt Signaling Pathway antibodies  CD28 Dependent PI3K/Akt Signaling Pathway Diagram
 CD28 Dependent Vav1 Pathway antibodies  CD28 Dependent Vav1 Pathway Diagram
 CTLA4 Inhibitory Signaling Pathway antibodies  CTLA4 Inhibitory Signaling Pathway Diagram
Diseases associated with anti-CD86 antibodyOrgans/Tissues associated with anti-CD86 antibody
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >1185 publications with CD86 and Necrosis
 Inflammation Antibodies  >869 publications with CD86 and Inflammation
 Death Antibodies  >322 publications with CD86 and Death
 Lung Diseases Antibodies  >284 publications with CD86 and Lung Diseases
 Neoplasms, Experimental Antibodies  >212 publications with CD86 and Neoplasms, Experimental
 Liver Diseases Antibodies  >201 publications with CD86 and Liver Diseases
 Cardiovascular Diseases Antibodies  >193 publications with CD86 and Cardiovascular Diseases
 Brain Diseases Antibodies  >157 publications with CD86 and Brain Diseases
 Dermatitis, Contact Antibodies  >112 publications with CD86 and Dermatitis, Contact
 Kidney Diseases Antibodies  >93 publications with CD86 and Kidney Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >5390 publications with CD86 and Blood
 Spleen Antibodies  >706 publications with CD86 and Spleen
 Lymph Node Antibodies  >664 publications with CD86 and Lymph Node
 Lung Antibodies  >363 publications with CD86 and Lung
 Vascular Antibodies  >201 publications with CD86 and Vascular
 Kidney Antibodies  >172 publications with CD86 and Kidney
 Brain Antibodies  >167 publications with CD86 and Brain
 Thymus Antibodies  >127 publications with CD86 and Thymus
 Eye Antibodies  >92 publications with CD86 and Eye
 Placenta Antibodies  >47 publications with CD86 and Placenta
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