Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Antibody rightarrow CD95 rightarrow Monoclonal CD95  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • Osteopontin (OPN) ELISA Kit
 • 25-Hydroxy vitamin D (25OHVD) ELISA Kit
 • EPG5 Antibody
 • kelch-like 22 (KLHL22) Antibody
 • Cytochrome P450 3A43 (CYP3A43) ELISA Kit
 • Reelin (RELN) ELISA Kit
 • Glycophorin A (GYPA) Antibody
 • Factor XIIa inhibitor (SERPING1) Recombinant Protein
 • Substance P (S.P) ELISA Kit
 • Human IgA lambda (dimer) Peptide
 • Otubain 1 (OTUB1) Recombinant Protein
 • Ultra Sensitive Prostate Specific Antigen (PSA U S) ELISA Kit
 • GILZ Antibody
 • GT-34 ELISA Kit
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

anti-CD95 antibody :: Mouse CD95 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS212192
Unit / Price
0.2 mg  /  $415 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CD95, Monoclonal Antibody

★Popular Item★
 Also Known As   

MOUSE ANTI HUMAN CD95

 Product Gene Name   

anti-CD95 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 OMIM    134637
 3D Structure    ModBase 3D Structure for P25445
Section Bar
 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    LOB 3/17
 Host    Mouse
 Species Reactivity    Rhesus Monkey
Section Bar
 Form/Format    Purified
Purified IgG - liquid
 Concentration    IgG concentration 1.0 mg/ml (lot specific)
Section Bar
 Perservative Stabilisers    0.09% Sodium Azide
Preparation
 Immunogen    Fusion protein comprising extracellular domain of human Fas linked to human Fc.
Fusion Partners
 Target Species    Human
Section Bar
 Preparation and Storage    Store at 4 degree C or at -20 degree C if preferred. This product should be stored undiluted. Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
 Other Notes    Small volumes of anti-CD95 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 

Product Description specifically for anti-CD95 antibody

   Mouse anti Human CD95 antibody, clone LOB 3/17 recognizes the human CD95 cell surface antigen, a 40-50kDa glycoprotein expressed by activated T and B cells, NK cells and thymocytes.
 Applications Tested/Suitable for anti-CD95 antibody   

Flow cytometry (FC/FACS), Immunoprecipitation (IP)

 Application Notes for anti-CD95 antibody    Flow Cytometry: Use 10ul of the suggested working dilution to label 106 cells in 100ul.
Flow Cytometry: Minimum Dilution: 1/50; Maximum Dilution: 1/100
Immunoprecipitation: Maximum Dilution: 20ug/ml
Section Bar
 Testing Data of anti-CD95 antibody    Staining of HUT78 T cell line with Mouse anti Human CD95:FITC (MBS210718)
anti-CD95 antibody Testing Data image
Section Bar
 Testing Data of anti-CD95 antibody    Staining of human peripheral blood granulocytes with Mouse anti Human CD95:Alexa Fluor 647 (MBS212192A647)
anti-CD95 antibody Testing Data image
Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for CD95. It may not necessarily be applicable to this product.
 NCBI GI #    4507583
 NCBI GeneID    355
 NCBI Accession #    NP_000034.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000043.4 [Other Products]
Section Bar
 UniProt Primary Accession #    P25445 [Other Products]
 UniProt Secondary Accession #    Q14292; Q14293; Q14294; Q14295; Q16652; Q5T9P1; Q5T9P2; Q5T9P3; Q6SSE9; A9UJX4; B6VNV4 [Other Products]
 UniProt Related Accession #    P25445 [Other Products]
 Molecular Weight    24,781 Da
Table BarTOPTable Bar
 NCBI Official Full Name    tumor necrosis factor receptor superfamily member 6 isoform 1
 NCBI Official Synonym Full Names    Fas cell surface death receptor
 NCBI Official Symbol    FAS [Similar Products]
 NCBI Official Synonym Symbols   
APT1; CD95; FAS1; APO-1; FASTM; ALPS1A; TNFRSF6
[Similar Products]
 NCBI Protein Information    tumor necrosis factor receptor superfamily member 6; APO-1 cell surface antigen; CD95 antigen; Delta Fas/APO-1/CD95; FAS 827dupA; FAS receptor variant 9; FASLG receptor; Fas (TNF receptor superfamily, member 6); Fas AMA; TNF receptor superfamily member 6; apoptosis antigen 1; apoptosis-mediating surface antigen FAS; tumor necrosis factor receptor superfamily, member 6
 UniProt Protein Name    Tumor necrosis factor receptor superfamily member 6
 UniProt Synonym Protein Names   
Apo-1 antigen; Apoptosis-mediating surface antigen FAS; FASLG receptor; CD_antigen: CD95
 UniProt Gene Name    FAS [Similar Products]
 UniProt Synonym Gene Names    APT1; FAS1; TNFRSF6 [Similar Products]
 UniProt Entry Name    TNR6_HUMAN
Section Bar
 NCBI Summary for CD95    The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. Several alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated mRNA decay (NMD). The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform. [provided by RefSeq, Mar 2011]
Section Bar
 UniProt Comments for CD95    FAS: Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death- inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS- mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro). Binds DAXX. Interacts with HIPK3. Part of a complex containing HIPK3 and FADD. Binds RIPK1 and FAIM2. Interacts with BRE and FEM1B. Interacts with FADD. Isoform 1 and isoform 6 are expressed at equal levels in resting peripheral blood mononuclear cells. After activation there is an increase in isoform 1 and decrease in the levels of isoform 6. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: Apoptosis; Cell surface; Receptor, cytokine; Membrane protein, integral

Chromosomal Location of Human Ortholog: 10q24.1

Cellular Component: cell surface; cytoplasm; integral to membrane; plasma membrane; CD95 death-inducing signaling complex; nucleus; cytosol; lipid raft; external side of plasma membrane

Molecular Function: identical protein binding; signal transducer activity; protein binding; transmembrane receptor activity; receptor activity; kinase binding

Biological Process: circadian rhythm; caspase activation; spleen development; regulation of myeloid cell differentiation; renal system process; transformed cell apoptosis; positive regulation of apoptosis; apoptosis; positive regulation of protein homooligomerization; regulation of lymphocyte differentiation; response to toxin; response to glucocorticoid stimulus; negative regulation of B cell activation; signal transduction; negative thymic T cell selection; regulation of apoptosis; inflammatory cell apoptosis; B cell mediated immunity; induction of apoptosis via death domain receptors; protein complex assembly; gene expression; immunoglobulin production; activated T cell apoptosis; protein homooligomerization; negative regulation of apoptosis

Disease: Autoimmune Lymphoproliferative Syndrome
Table BarTOPTable Bar
 Research Articles on CD95    1. Rheumatoid arthritis B cells had reduced Fas expression compared with their healthy counterparts and were resistant to Fas-mediated apoptosis.
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Pathways associated with anti-CD95 antibodyDiseases associated with anti-CD95 antibody
 Products by Pathway  Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 African Trypanosomiasis Pathway antibodies  African Trypanosomiasis Pathway Diagram
 African Trypanosomiasis Pathway antibodies  African Trypanosomiasis Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimers Disease Pathway antibodies  Alzheimers Disease Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >5007 publications with CD95 and Necrosis
 Autoimmune Diseases Antibodies  >2024 publications with CD95 and Autoimmune Diseases
 Inflammation Antibodies  >1775 publications with CD95 and Inflammation
 Nervous System Diseases Antibodies  >1555 publications with CD95 and Nervous System Diseases
 Disease Models, Animal Antibodies  >1478 publications with CD95 and Disease Models, Animal
 Liver Diseases Antibodies  >1436 publications with CD95 and Liver Diseases
 Fatty Liver Antibodies  >1000 publications with CD95 and Fatty Liver
 Hematologic Diseases Antibodies  >673 publications with CD95 and Hematologic Diseases
 Heart Diseases Antibodies  >542 publications with CD95 and Heart Diseases
 Kidney Diseases Antibodies  >536 publications with CD95 and Kidney Diseases
Organs/Tissues associated with anti-CD95 antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >9324 publications with CD95 and Blood
 Liver Antibodies  >2936 publications with CD95 and Liver
 Brain Antibodies  >1646 publications with CD95 and Brain
 Bone Antibodies  >1398 publications with CD95 and Bone
 Lung Antibodies  >1216 publications with CD95 and Lung
 Muscle Antibodies  >1118 publications with CD95 and Muscle
 Vascular Antibodies  >1075 publications with CD95 and Vascular
 Heart Antibodies  >902 publications with CD95 and Heart
 Kidney Antibodies  >859 publications with CD95 and Kidney
 Bone Marrow Antibodies  >824 publications with CD95 and Bone Marrow
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions