NP_001116370.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
17,128 Da
NCBI Official Full Name
CD99 antigen isoform b
NCBI Official Synonym Full Names
CD99 molecule
NCBI Official Synonym Symbols
MIC2; HBA71; MIC2X; MIC2Y; MSK5X [Similar Products]
NCBI Protein Information
CD99 antigen; E2 antigen; MIC2 (monoclonal antibody 12E7); T-cell surface glycoprotein E2; antigen identified by monoclonal 12E7, Y homolog; antigen identified by monoclonal antibodies 12E7, F21 and O13; surface antigen MIC2
UniProt Protein Name
CD99 antigen
UniProt Synonym Protein Names
12E7; E2 antigen; Protein MIC2; T-cell surface glycoprotein E2; CD_antigen: CD99
UniProt Synonym Gene Names
UniProt Entry Name
CD99_HUMAN
NCBI Summary for CD99
The protein encoded by this gene is a cell surface glycoprotein involved in leukocyte migration, T-cell adhesion, ganglioside GM1 and transmembrane protein transport, and T-cell death by a caspase-independent pathway. In addition, the encoded protein may have the ability to rearrange the actin cytoskeleton and may also act as an oncosuppressor in osteosarcoma. Cyclophilin A binds to CD99 and may act as a signaling regulator of CD99. This gene is found in the pseudoautosomal region of chromosomes X and Y and escapes X-chromosome inactivation. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2013]
UniProt Comments for CD99
CD99: Involved in T-cell adhesion processes and in spontaneous rosette formation with erythrocytes. Plays a role in a late step of leukocyte extravasation helping leukocytes to overcome the endothelial basement membrane. Acts at the same site as, but independently of, PECAM1. Involved in T-cell adhesion processes. Belongs to the CD99 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: Xp22.32 and Yp11.3
Cellular Component: focal adhesion; integral to plasma membrane; cytoplasm; plasma membrane
Biological Process: cell adhesion
Research Articles on CD99
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Products associated with anti-CD99 antibody
Pathways associated with anti-CD99 antibody
Diseases associated with anti-CD99 antibody
Organs/Tissues associated with anti-CD99 antibody
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