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anti-CDC5L antibody :: Mouse anti-Human CDC5L Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS120141
Unit / Price
0.1 mg  /  $345 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CDC5L, Monoclonal Antibody

 Also Known As   

Mouse monoclonal antibody Anti-Human CDC5L

 Product Synonym Names    Homo sapiens CDC5 cell division cycle 5-like (S. pombe) (CDC5L); CEF1; hCDC5; PCDC5RP; KIAA0432; dJ319D22.1
 Product Gene Name   

anti-CDC5L antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    602868
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    2136C1a
 Host    Mouse
 Species Reactivity    Human
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 Concentration    100 ug/ml (1.0 ml) (lot specific)
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 Preparation    This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.
 Sterility    Filtered through a 0.22 um membrane.
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 Other Notes    Small volumes of anti-CDC5L antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CDC5L antibody

   The protein encoded by this gene shares a significant similarity with Schizosaccharomyces pombe cdc5 gene product, which is a cell cycle regulator important for G2/M transition. This protein has been demonstrated to act as a positive regulator of cell cycle G2/M progression. It was also found to be an essential component of a non-snRNA spliceosome, which contains at least five additional protein factors and is required for the second catalytic step of pre-mRNA splicing. [NCBI Entrez Gene Summary]
 Applications Tested/Suitable for anti-CDC5L antibody   

Dot Blot (DB), Immunocytochemistry (ICC), Immunoprecipitation (IP), Western Blot (WB), Flow Cytometry (FC/FACS)

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 Quality Control of anti-CDC5L antibody    Western blot analysis of immunized recombinant protein, using anti-CDC5L monoclonal antibody.
anti-CDC5L antibody Quality Control image
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 Quality Control #2 of anti-CDC5L antibody    Arrow indicates the region of immunized recombinant protein carrying 50-200 amino acids.
anti-CDC5L antibody Quality Control #2 image
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 Western Blot (WB) of anti-CDC5L antibody    Detection of CDC5L by Western blot.

Samples: Whole cell lysate from human HeLa (H, 50 ug), mouse NIH3T3 (M, 50 ug) and rat F2408 (R, 50 ug) cells. [Lot No. 2136C1a-1]

Predicted molecular weight: 92 kDa
anti-CDC5L antibody Western Blot (WB) (WB) image
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 Immunoprecipitation (IP) of anti-CDC5L antibody    Immunoprecipitation: RIPA lysate of HeLa cells was incubated with anti-CDC5L mAb. [Lot No. 2136C1a-1]

Predicted molecular weight: 92 kDa
anti-CDC5L antibody Immunoprecipitation (IP) (IP) image
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 Flow Cytometry (FC/FACS) of anti-CDC5L antibody    HeLa cells were fixed in 2% paraformaldehyde/PBS and then permeabilized in 90% methanol. Cells were stained with anti-CDC5L mAb (shaded) or isotype control (unshaded) followed by Alexa Fluor(R) 488-conjugated goat anti-mouse IgG. [Lot No. 2136C1a-1]
anti-CDC5L antibody Flow Cytometry (FC/FACS) (FC/FACS) image
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 Immunocytochemistry (ICC) of anti-CDC5L antibody    Immunostaining analysis in HeLa cells. HeLa cells were fixed with 4% paraformaldehyde and permeabilized with 0.1% Triton X-100 in PBS. The cells were immunostained with anti-CDC5L mAb. [Lot No. 2136C1a-1]
anti-CDC5L antibody Immunocytochemistry (ICC) (ICC) image
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NCBI/Uniprot data below describe general gene information for CDC5L. It may not necessarily be applicable to this product.
 NCBI GI #    356640202
 NCBI GeneID    988
 NCBI Accession #    NP_001244.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001253 [Other Products]
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 UniProt Secondary Accession #    Q76N46; Q99974 [Other Products]
 UniProt Related Accession #    Q99459 [Other Products]
 Molecular Weight    92,251 Da
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 NCBI Official Full Name    Homo sapiens cell division cycle 5-like (CDC5L), mRNA
 NCBI Official Synonym Full Names    cell division cycle 5-like
 NCBI Official Symbol    CDC5L [Similar Products]
 NCBI Official Synonym Symbols   
CDC5; CEF1; PCDC5RP; CDC5-LIKE; dJ319D22.1
[Similar Products]
 NCBI Protein Information    cell division cycle 5-like protein; CDC5 cell division cycle 5-like; Cdc5-related protein; dJ319D22.1 (CDC5-like protein); pombe cdc5-related protein
 UniProt Protein Name    Cell division cycle 5-like protein
 UniProt Synonym Protein Names   
Pombe cdc5-related protein
 Protein Family    Cell division cycle 5-like protein
 UniProt Gene Name    CDC5L [Similar Products]
 UniProt Entry Name    CDC5L_HUMAN
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 NCBI Summary for CDC5L    The protein encoded by this gene shares a significant similarity with Schizosaccharomyces pombe cdc5 gene product, which is a cell cycle regulator important for G2/M transition. This protein has been demonstrated to act as a positive regulator of cell cycle G2/M progression. It was also found to be an essential component of a non-snRNA spliceosome, which contains at least five additional protein factors and is required for the second catalytic step of pre-mRNA splicing. [provided by RefSeq, Jul 2008]
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 UniProt Comments for CDC5L    CDC5L: is a spliceosome protein that binds DNA and that also regulates transcription. Is a positive regulator of cell cycle G2/M progression. Is an essential component of non-snRNA spliceosomes and is required for the second catalytic step of pre-mRNA splicing. Binds adeno-pre-mRNA in an ATP-stimulated manner. Is part of a spliceosomal 'core' complex that includes CDC5L, SF2, PRLI, SPF27, HSP7C, PRPF19/SNEV, GCN1L. Identified in the spliceosome C complex. Has been associated with aneuploidy in aging cells and in tumorigenesis. The genomic region containing the gene for CDC5L (6p21.1) is frequently amplified in osteosarcomas.

Protein type: Spliceosome; RNA processing; DNA-binding; RNA splicing; Transcription factor; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 6p21

Cellular Component: nucleoplasm; DNA replication factor A complex; membrane; cytoplasm; nucleolus; nuclear speck; nucleus

Molecular Function: protein binding; DNA binding; chromatin binding

Biological Process: nuclear mRNA splicing, via spliceosome; regulation of transcription, DNA-dependent; transcription, DNA-dependent; RNA splicing; gene expression; DNA repair
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 Research Articles on CDC5L    1. The N-terminal ARM-repeat domain of CTNNBL1 provides a binding site for CDC5L, a binding partner in the Prp19-CDC5L complex.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CDC5L antibodyPathways associated with anti-CDC5L antibody
 Reference Product  PubMed Publications
 PLRG1 antibody  >10 publications with CDC5L and PLRG1
 PRPF19 antibody  >9 publications with CDC5L and PRPF19
 CTNNBL1 antibody  >6 publications with CDC5L and CTNNBL1
 PPP1R8 antibody  >2 publications with CDC5L and PPP1R8
 BCAS2 antibody  >2 publications with CDC5L and BCAS2
 Products by Pathway  Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Processing Of Capped Intron-Containing Pre-mRNA Pathway antibodies  Processing Of Capped Intron-Containing Pre-mRNA Pathway Diagram
 Spliceosome Pathway antibodies  Spliceosome Pathway Diagram
 Spliceosome Pathway antibodies  Spliceosome Pathway Diagram
 Spliceosome, 35S U5-snRNP Pathway antibodies  Spliceosome, 35S U5-snRNP Pathway Diagram
 Spliceosome, 35S U5-snRNP Pathway antibodies  Spliceosome, 35S U5-snRNP Pathway Diagram
 Spliceosome, Prp19/CDC5L Complex Pathway antibodies  Spliceosome, Prp19/CDC5L Complex Pathway Diagram
 Spliceosome, Prp19/CDC5L Complex Pathway antibodies  Spliceosome, Prp19/CDC5L Complex Pathway Diagram
 MRNA Splicing Pathway antibodies  MRNA Splicing Pathway Diagram
 MRNA Splicing - Major Pathway antibodies  MRNA Splicing - Major Pathway Diagram
Diseases associated with anti-CDC5L antibodyOrgans/Tissues associated with anti-CDC5L antibody
 Disease Name  Pubmed Publications
 Chromosome Aberrations Antibodies  >4 publications with CDC5L and Chromosome Aberrations
 Necrosis Antibodies  >3 publications with CDC5L and Necrosis
 Carcinoma Antibodies  >2 publications with CDC5L and Carcinoma
 Cell Transformation, Neoplastic Antibodies  >1 publications with CDC5L and Cell Transformation, Neoplastic
 Carcinoma, Hepatocellular Antibodies  >1 publications with CDC5L and Carcinoma, Hepatocellular
 Inflammation Antibodies  >1 publications with CDC5L and Inflammation
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >5 publications with CDC5L and Bone
 Blood Antibodies  >3 publications with CDC5L and Blood
 Muscle Antibodies  >2 publications with CDC5L and Muscle
 Kidney Antibodies  >2 publications with CDC5L and Kidney
 Embryonic Tissue Antibodies  >2 publications with CDC5L and Embryonic Tissue
 Liver Antibodies  >2 publications with CDC5L and Liver
 Heart Antibodies  >1 publications with CDC5L and Heart
 Eye Antibodies  >1 publications with CDC5L and Eye
 Ovary Antibodies  >1 publications with CDC5L and Ovary
 Uncharacterized Tissue Antibodies  >1 publications with CDC5L and Uncharacterized Tissue
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