NM_001308176.1
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
97,040 Da
NCBI Official Full Name
cadherin-2 isoform 2
NCBI Official Synonym Full Names
cadherin 2
NCBI Protein Information
cadherin-2
UniProt Protein Name
Cadherin-2
UniProt Synonym Protein Names
CDw325; Neural cadherin; N-cadherin; CD_antigen: CD325
UniProt Synonym Gene Names
UniProt Entry Name
CADH2_HUMAN
NCBI Summary for CDH2
This gene encodes a classical cadherin and member of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein is proteolytically processed to generate a calcium-dependent cell adhesion molecule and glycoprotein. This protein plays a role in the establishment of left-right asymmetry, development of the nervous system and the formation of cartilage and bone. [provided by RefSeq, Nov 2015]
UniProt Comments for CDH2
CDH2: Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density. Interacts with CDCP1. Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN. Interacts with PCDH8; this complex may also include TAOK2. The interaction with PCDH8 may lead to internalization through TAOK2/p38 MAPK pathway.
Protein type: Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 18q11.2
Cellular Component: catenin complex; cell-cell adherens junction; cortical actin cytoskeleton; cytoplasm; focal adhesion; intercellular junction; lamellipodium; plasma membrane
Molecular Function: alpha-catenin binding; beta-catenin binding; gamma-catenin binding; protein binding
Biological Process: cell adhesion; glial cell differentiation; positive regulation of muscle cell differentiation
Research Articles on CDH2
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Products associated with anti-CDH2 antibody
Pathways associated with anti-CDH2 antibody
Diseases associated with anti-CDH2 antibody
Organs/Tissues associated with anti-CDH2 antibody
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