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anti-CDK5 antibody :: Mouse CDK5 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS475069
Unit / Price
0.1 mL  /  $335 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CDK5, Monoclonal Antibody

★Popular Item★
 Also Known As   

Anti-CDK5 (N-term) Mouse mAb

 Product Synonym Names    Cdk 5; Cdk5; CDK5_HUMAN; Cell division protein kinase 5; Crk6; Cyclin dependent kinase 5; Cyclin-dependent kinase 5; Protein kinase CDK5 splicing; PSSALRE; Serine threonine protein kinase PSSALRE; Serine/threonine-protein kinase PSSALRE; Tau protein kinase II catalytic subunit; TPKII catalytic subunit
 Product Gene Name   

anti-CDK5 antibody

[Similar Products]
 Product Synonym Gene Name    PSSALRE [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    X66364 mRNA
 3D Structure    ModBase 3D Structure for Q00535
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    2E8-F9-B7-C11
 Host    Mouse
 Species Reactivity    Human, Mouse, Rat, Monkey
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 Form/Format    Ascites
 Concentration    1mg/ml (lot specific)
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 Immunogen    Purified recombinant human CDK5 (N-terminus) protein fragments expressed in E Coli.
 Sensitivity    This antibody detects endogenous levels of CDK5 (N-terminus) and does not cross-react with related proteins.
 Sequence Similarities    Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. Contains 1 protein kinase domain
 UniPort Summary Function    Probably involved in the control of the cell cycle. Interacts with D1 and D3-type G1 cyclins. Can phosphorylate histone H1, tau, MAP2 and NF-H and NF-M. Also interacts with p35 which activates the kinase.
 Subunit Structure    Heterodimer composed of a catalytic subunit CDK5 and a regulatory subunit CDK5R1 (p25) and macromolecular complex composed of at least CDK5, CDK5R1 (p35) and CDK5RAP1 or CDK5RAP2 or CDK5RAP3. Only the heterodimer shows kinase activity. Under neurotoxic stress and neuronal injury conditions, p35 is cleaved by calpain to generate p25 that hyperactivates CDK5, that becomes functionally disabled and often toxic. Found in a trimolecular complex with CABLES1 and ABL1. Interacts with CABLES1 and CABLES2. Interacts with AATK and GSTP1. Binds to HDAC1 when in complex with p25. Interaction with myristoylation p35 promotes CDK5 association with membranes. Both isoforms 1 and 2 interacts with beta-catenin/CTNNB1. Interacts with delta-catenin/CTNND2 and APEX1. Interacts with P53/TP53 in neurons. Interacts with EPHA4; may mediate the activation of NGEF by EPHA4
 Subcellular Location    Cytoplasm. Cell membrane; Peripheral membrane protein. Perikaryon. Cell projection
 Antibody diluents    5% w/v nonfat dry milk, 1x PBS, 0.1%Tween-20
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 Preparation and Storage    Aliquot and store at -20C. Avoid repeated freeze/thaw cycles
 Other Notes    Small volumes of anti-CDK5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CDK5 antibody

   Cdks (cyclin-dependent kinases) are heteromeric serine/threonine kinases that control progression through the cell cycle in concert with their regulatory subunits, the cyclins. Although there are 12 different cdk genes, only 5 have been shown to directly drive the cell cycle (Cdk1, -2, -3, -4, and -6). Following extracellular mitogenic stimuli, cyclin D gene expression is upregulated. Cdk4 forms a complex with cyclin D and phosphorylates Rb protein, leading to liberation of the transcription factor E2F. E2F induces transcription of genes including cyclins A and E, DNA polymerase and thymidine kinase. Cdk4-cyclin E complexes form and initiate G1/S transition. Subsequently, Cdk1-cyclin B complexes form and induce G2/M phase transition. Cdk1-cyclin B activation induces the breakdown of the nuclear envelope and the initiation of mitosis. Cdks are constitutively expressed and are regulated by several kinases and phosphastases, including Wee1, CDK-activating kinase and Cdc25 phosphatase. In addition, cyclin expression is induced by molecular signals at specific points of the cell cycle, leading to activation of Cdks. Tight control of Cdks is essential as misregulation can induce unscheduled proliferation, and genomic and chromosomal instability. Cdk4 has been shown to be mutated in some types of cancer, whilst a chromosomal rearrangement can lead to Cdk6 overexpression in lymphoma, leukemia and melanoma. Cdks are currently under investigation as potential targets for antineoplastic therapy, but as Cdks are essential for driving each cell cycle phase, therapeutic strategies that block Cdk activity are unlikely to selectively target tumor cells.
 Product Categories/Family for anti-CDK5 antibody    Metabolism; Types of disease; Obesity; Cancer; Cell cycle; Cell division; Neuroscience; Neurology process; Neurogenesis
 Applications Tested/Suitable for anti-CDK5 antibody   

Western Blot (WB), Immunocytochemistry (ICC)

 Application Notes for anti-CDK5 antibody    WB: 1:500
ICC: 1:150
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 Western Blot (WB) of anti-CDK5 antibody    Western blot detection of CDK5 (N-terminus) in 3T3, Hela, PC-12, COS7, Jurkat and K562 lysates using Cdk5 mouse mAb (1:500 diluted).Predicted band size: 36KDa.Observed band size: 36KDa.Exposure time:5min.
anti-CDK5 antibody Western Blot (WB) (WB) image
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 Immunocytochemistry (ICC) of anti-CDK5 antibody    Immunocytochemistry of HeLa cells using anti-CDK5 (N-terminus) mouse mAb diluted 1:150
anti-CDK5 antibody Immunocytochemistry (ICC) (ICC) image
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NCBI/Uniprot data below describe general gene information for CDK5. It may not necessarily be applicable to this product.
 NCBI GI #    256542306
 NCBI GeneID    1020
 NCBI Accession #    NP_001157882.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_004935 [Other Products]
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 UniProt Primary Accession #    Q00535 [Other Products]
 UniProt Secondary Accession #    A1XKG3 [Other Products]
 UniProt Related Accession #    Q00535 [Other Products]
 Molecular Weight    36
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 NCBI Official Full Name    cyclin-dependent-like kinase 5 isoform 2
 NCBI Official Synonym Full Names    cyclin dependent kinase 5
 NCBI Official Symbol    CDK5 [Similar Products]
 NCBI Official Synonym Symbols   
LIS7; PSSALRE
[Similar Products]
 NCBI Protein Information    cyclin-dependent-like kinase 5
 UniProt Protein Name    Cyclin-dependent-like kinase 5
 UniProt Synonym Protein Names   
Cell division protein kinase 5; Serine/threonine-protein kinase PSSALRE; Tau protein kinase II catalytic subunit; TPKII catalytic subunit
 Protein Family    CDK5RAP1-like protein
 UniProt Gene Name    CDK5 [Similar Products]
 UniProt Synonym Gene Names    CDKN5; TPKII catalytic subunit [Similar Products]
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 NCBI Summary for CDK5    This gene encodes a proline-directed serine/threonine kinase that is a member of the cyclin-dependent kinase family of proteins. Unlike other members of the family, the protein encoded by this gene does not directly control cell cycle regulation. Instead the protein, which is predominantly expressed at high levels in mammalian postmitotic central nervous system neurons, functions in diverse processes such as synaptic plasticity and neuronal migration through phosphorylation of proteins required for cytoskeletal organization, endocytosis and exocytosis, and apoptosis. In humans, an allelic variant of the gene that results in undetectable levels of the protein has been associated with lethal autosomal recessive lissencephaly-7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015]
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 UniProt Comments for CDK5    CDK5: a protein kinase of the CDK family. Unlike other members of this family, it is not activated by cyclins but by p35 (CDK5R1) and p39. An important regulator of neuronal positioning during brain development. May also play a role in synaptogenesis and neurotransmission. Substrates include TAU, MAP2, NF-H and -M, Nudel, PDE6, beta-catenin, amphyphysin, dynamin I, synapsin 1, Munc-18, and NMDA receptor 2A. Plays a role in myogenesis, haematopoietic cell differentiation, spermatogenesis, insulin secretion, and lens differentiation. Implicated in the pathology of neurofibrillary tangles and formation of senile plaques, hallmarks of Alzheimer?s disease. Induces tau phosphorylation and aggregation and neurofibrillary tangle deposition and neurodegeneration in in vitro and in vivo animal models. Brain samples from Alzeimer?s pateints show elevated CDK5 activity.

Protein type: CDK family; CDK/CDK5 subfamily; CDK5 subfamily; CMGC group; Cell cycle regulation; EC 2.7.11.1; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)

Chromosomal Location of Human Ortholog: 7q36.1

Cellular Component: axon; cell junction; cell soma; cytoplasm; cytosol; dendrite; growth cone; membrane; neuromuscular junction; nucleoplasm; nucleus; plasma membrane; postsynaptic density

Molecular Function: acetylcholine receptor activator activity; cyclin-dependent protein kinase activity; ErbB-2 class receptor binding; ErbB-3 class receptor binding; kinase activity; protein binding; protein kinase activity; protein serine/threonine kinase activity; tau-protein kinase activity

Biological Process: axon extension; cell proliferation; negative regulation of proteolysis; negative regulation of transcription, DNA-dependent; neurite development; neuron apoptosis; neuron differentiation; neuron migration; oligodendrocyte differentiation; peptidyl-serine phosphorylation; phosphorylation; positive regulation of neuron apoptosis; regulation of apoptosis; regulation of macroautophagy; regulation of synaptic plasticity; synaptic transmission; synaptic vesicle endocytosis; synaptic vesicle exocytosis; synaptogenesis

Disease: Lissencephaly 7 With Cerebellar Hypoplasia
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 Research Articles on CDK5    1. the results suggest that CK1delta activity can be modulated by the interplay between CK1delta and CDK2/E or CDK5/p35.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CDK5 antibodyPathways associated with anti-CDK5 antibody
 Reference Product  PubMed Publications
 APP antibody  >36 publications with CDK5 and APP
 SRC antibody  >33 publications with CDK5 and SRC
 SET antibody  >26 publications with CDK5 and SET
 MAPT antibody  >24 publications with CDK5 and MAPT
 CDKN1B antibody  >22 publications with CDK5 and CDKN1B
 FYN antibody  >17 publications with CDK5 and FYN
 PCNA antibody  >16 publications with CDK5 and PCNA
 DAB1 antibody  >15 publications with CDK5 and DAB1
 PPP1R1B antibody  >14 publications with CDK5 and PPP1R1B
 NDEL1 antibody  >12 publications with CDK5 and NDEL1
 Products by Pathway  Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimers Disease Pathway antibodies  Alzheimers Disease Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 BDNF Signaling Pathway antibodies  BDNF Signaling Pathway Diagram
 CRMPs In Sema3A Signaling Pathway antibodies  CRMPs In Sema3A Signaling Pathway Diagram
 Cocaine Addiction Pathway antibodies  Cocaine Addiction Pathway Diagram
 Cocaine Addiction Pathway antibodies  Cocaine Addiction Pathway Diagram
Diseases associated with anti-CDK5 antibodyOrgans/Tissues associated with anti-CDK5 antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >390 publications with CDK5 and Nervous System Diseases
 Brain Diseases Antibodies  >319 publications with CDK5 and Brain Diseases
 Neoplasms Antibodies  >113 publications with CDK5 and Neoplasms
 Nerve Degeneration Antibodies  >73 publications with CDK5 and Nerve Degeneration
 Drug Toxicity Antibodies  >58 publications with CDK5 and Drug Toxicity
 Movement Disorders Antibodies  >53 publications with CDK5 and Movement Disorders
 Inflammation Antibodies  >37 publications with CDK5 and Inflammation
 Pain Antibodies  >32 publications with CDK5 and Pain
 Learning Disorders Antibodies  >31 publications with CDK5 and Learning Disorders
 Cardiovascular Diseases Antibodies  >31 publications with CDK5 and Cardiovascular Diseases
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >792 publications with CDK5 and Brain
 Embryonic Tissue Antibodies  >70 publications with CDK5 and Embryonic Tissue
 Blood Antibodies  >62 publications with CDK5 and Blood
 Muscle Antibodies  >60 publications with CDK5 and Muscle
 Eye Antibodies  >46 publications with CDK5 and Eye
 Liver Antibodies  >23 publications with CDK5 and Liver
 Kidney Antibodies  >23 publications with CDK5 and Kidney
 Testis Antibodies  >18 publications with CDK5 and Testis
 Lung Antibodies  >16 publications with CDK5 and Lung
 Pancreas Antibodies  >16 publications with CDK5 and Pancreas
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