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anti-CDKN2A antibody :: Mouse CDKN2A Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS8527903 anti-CDKN2A antibody
Unit / Price
0.1 mL  /  $290 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CDKN2A, Monoclonal Antibody

★Popular Item★
 Also Known As   

Mouse Monoclonal Antibody to CDKN2A

 Product Synonym Names    ARF; MLM; P14; P16; P19; CMM2; INK4; MTS1; TP16; CDK4I; CDKN2; INK4A; MTS-1; P14ARF; P19ARF; P16INK4; P16INK4A; P16-INK4A
 Product Gene Name   

anti-CDKN2A antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    155601
 3D Structure    ModBase 3D Structure for P31213
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    1D7D2A1
 Host    Mouse
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 Immunogen    Full (1-156)
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 Preparation and Storage    Store at -20C/ 1 year.
 Other Notes    Small volumes of anti-CDKN2A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-CDKN2A antibody   

RWB, TWB, LWB, IHC, FCM.

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NCBI/Uniprot data below describe general gene information for CDKN2A. It may not necessarily be applicable to this product.
 NCBI GI #    304376272
 NCBI GeneID    1029
 NCBI Accession #    NP_001182061.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001195132.1 [Other Products]
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 UniProt Primary Accession #    P31213 [Other Products]
 UniProt Secondary Accession #    O95440; Q15191; Q5VVJ5; Q96B52; Q9NP05; A5X2G7; D3DRK1 [Other Products]
 UniProt Related Accession #    P42771; Q8N726 [Other Products]
 Molecular Weight    16.5kDa
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 NCBI Official Full Name    cyclin-dependent kinase inhibitor 2A isoform p16gamma
 NCBI Official Synonym Full Names    cyclin dependent kinase inhibitor 2A
 NCBI Official Symbol    CDKN2A [Similar Products]
 NCBI Official Synonym Symbols   
ARF; MLM; P14; P16; P19; CMM2; INK4; MTS1; TP16; CDK4I; CDKN2; INK4A; MTS-1; P14ARF; P19ARF; P16INK4; P16INK4A; P16-INK4A
[Similar Products]
 NCBI Protein Information    cyclin-dependent kinase inhibitor 2A
 UniProt Protein Name    Cyclin-dependent kinase inhibitor 2A
 UniProt Synonym Protein Names   
Cyclin-dependent kinase 4 inhibitor A; CDK4I; Multiple tumor suppressor 1; MTS-1; p16-INK4a; p16-INK4; p16INK4A
 Protein Family    CDKN2A-interacting protein
 UniProt Gene Name    CDKN2A [Similar Products]
 UniProt Synonym Gene Names    CDK4I; MTS-1; p16-INK4; p16INK4A [Similar Products]
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 NCBI Summary for CDKN2A    This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, the E3 ubiquitin-protein ligase MDM2, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene. [provided by RefSeq, Sep 2012]
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 UniProt Comments for CDKN2A    Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein.
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 Research Articles on CDKN2A    1. The p16-/HPV L1- pattern was significantly associated with the regression of CIN1. Moving from cervical intraepithelial neoplasia 1 (CIN1) to CIN2+ over time, p16+/HPV L1+ decreased, and p16+/HPV L1- increased.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CDKN2A antibodyPathways associated with anti-CDKN2A antibody
 Reference Product  PubMed Publications
 CDK4 antibody  >947 publications with CDKN2A and CDK4
 CCND1 antibody  >822 publications with CDKN2A and CCND1
 TP53 antibody  >532 publications with CDKN2A and TP53
 MYC antibody  >409 publications with CDKN2A and MYC
 MDM2 antibody  >344 publications with CDKN2A and MDM2
 CDK6 antibody  >285 publications with CDKN2A and CDK6
 CDK2 antibody  >266 publications with CDKN2A and CDK2
 NPM1 antibody  >3 publications with CDKN2A and NPM1
 Products by Pathway  Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Modulation And Signaling Pathway antibodies  Apoptosis Modulation And Signaling Pathway Diagram
 Bladder Cancer Pathway antibodies  Bladder Cancer Pathway Diagram
 Bladder Cancer Pathway antibodies  Bladder Cancer Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Chronic Myeloid Leukemia Pathway antibodies  Chronic Myeloid Leukemia Pathway Diagram
Diseases associated with anti-CDKN2A antibodyOrgans/Tissues associated with anti-CDKN2A antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >7068 publications with CDKN2A and Neoplasms
 Adenocarcinoma Antibodies  >1178 publications with CDKN2A and Adenocarcinoma
 Urogenital Neoplasms Antibodies  >1086 publications with CDKN2A and Urogenital Neoplasms
 Cell Transformation, Neoplastic Antibodies  >681 publications with CDKN2A and Cell Transformation, Neoplastic
 Lymphoma Antibodies  >636 publications with CDKN2A and Lymphoma
 Lung Neoplasms Antibodies  >626 publications with CDKN2A and Lung Neoplasms
 Skin Neoplasms Antibodies  >586 publications with CDKN2A and Skin Neoplasms
 Neoplasms, Experimental Antibodies  >573 publications with CDKN2A and Neoplasms, Experimental
 Nervous System Diseases Antibodies  >550 publications with CDKN2A and Nervous System Diseases
 Glioma Antibodies  >456 publications with CDKN2A and Glioma
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >834 publications with CDKN2A and Blood
 Skin Antibodies  >746 publications with CDKN2A and Skin
 Lung Antibodies  >745 publications with CDKN2A and Lung
 Brain Antibodies  >460 publications with CDKN2A and Brain
 Liver Antibodies  >427 publications with CDKN2A and Liver
 Bone Antibodies  >337 publications with CDKN2A and Bone
 Lymph Antibodies  >304 publications with CDKN2A and Lymph
 Lymph Node Antibodies  >304 publications with CDKN2A and Lymph Node
 Stomach Antibodies  >281 publications with CDKN2A and Stomach
 Cervix Antibodies  >223 publications with CDKN2A and Cervix
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