NP_002474.4
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
carcinoembryonic antigen-related cell adhesion molecule 6 preproprotein
NCBI Official Synonym Full Names
carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
NCBI Protein Information
carcinoembryonic antigen-related cell adhesion molecule 6; normal cross-reacting antigen; Cluster of Differentiation 66c
UniProt Synonym Protein Names
Non-specific crossreacting antigen; Normal cross-reacting antigen; CD_antigen: CD66c
UniProt Synonym Gene Names
UniProt Entry Name
CEAM6_HUMAN
NCBI Summary for CEACAM6
This gene encodes a protein that belongs to the carcinoembryonic antigen (CEA) family whose members are glycosyl phosphatidyl inositol (GPI) anchored cell surface glycoproteins. Members of this family play a role in cell adhesion and are widely used as tumor markers in serum immunoassay determinations of carcinoma. This gene affects the sensitivity of tumor cells to adenovirus infection. The protein encoded by this gene acts as a receptor for adherent-invasive E. coli adhesion to the surface of ileal epithelial cells in patients with Crohn's disease. This gene is clustered with genes and pseudogenes of the cell adhesion molecules subgroup of the CEA family on chromosome 19. [provided by RefSeq, Apr 2014]
UniProt Comments for CEACAM6
CEACAM6: Belongs to the immunoglobulin superfamily. CEA family
Protein type: Membrane protein, integral; Membrane protein, GPI anchor
Chromosomal Location of Human Ortholog: 19q13.2
Cellular Component: integral to plasma membrane; plasma membrane
Molecular Function: protein binding
Biological Process: cell-cell signaling; blood coagulation; signal transduction; leukocyte migration
Product References and Citations for anti-CEACAM6 antibody
Zimmermann W (2002). Carcinoembryonic antigen. In Wiley Encyclopedia of Molecular Medicine
(T. Creighton, ed.), John Wiley & Sons Inc., New York, USA, pp. 459-462. Hammarström S (1999). The carcinoembryonic antigen (CEA) family: structures, suggested
functions and expression in normal and malignant tissues. Semin Cancer Biol. 9, 67-81. Scholzel S, Zimmermann W, Schwarzkopf G, Grunert F, Rogaczewski B and Thompson J
(2000). Carcinoembryonic antigen family members CEACAM6 and CEACAM7 are differentially
expressed in normal tissues and oppositely deregulated in hyperplastic colorectal polyps and
early adenomas. Am J Pathol 156, 595-605. Grunert F, Stocks SC, Nagel G., Zimmermann W, Thompson JA, Jantscheff P and Kromer
B. (1996). CD66 family Workshop: Binding of myeloid blind panel antibodies and CD66
Subsection antibodies to HeLa transfectants expressing individual CD66 molecules. In Leukocyte
Typing VI: White cell Differentiation Antigens (T. Kishimoto et al., eds.), Garland Publishing Inc.,
New York and London, pp. 1012-1025.
Research Articles on CEACAM6
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Products associated with anti-CEACAM6 antibody
Diseases associated with anti-CEACAM6 antibody
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