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anti-CEACAM8 antibody :: Mouse anti-Human CEACAM8 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS468020
Unit / Price
0.1 mg  /  $505 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CEACAM8, Monoclonal Antibody

 Also Known As   

anti-human CEACAM8 monoclonal antibody

 Product Synonym Names    CD66b; NCA-95
 Product Gene Name   

anti-CEACAM8 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    114890
 3D Structure    ModBase 3D Structure for P31997
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    GM2H6
 Host    Mouse
 Species Reactivity    Human
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 Specificity    anti-human CEACAM8 (CD66b/NCA-95)
 Purity/Purification    Protein G
 Form/Format    Purified
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 Buffer    phosphate buffered saline, pH 7.2
 Immunogen    genetic immunisation with cDNA encoding human CEACAM8
 Selection    based on recognition of the complete native protein expressed on transfected mammalian cells
 Immunogen    cDNA
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 Preparation and Storage    Short term: 2 degree C - 8 degree C; long term: -20 degree C (avoid repeated freezing and thawing)
 Other Notes    Small volumes of anti-CEACAM8 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CEACAM8 antibody

   Background: CEA-related cell adhesion molecule 8 (CEACAM8, CD66b) belongs to the carcinoembryonic antigen (CEA) gene family (1,3,4). It encodes a glycosylphosphatidylinositol (GPI)-linked glycoprotein with a Mr of 95,000 which is expressed in cells of the granulocyte-lineage. It is expressed in neutrophils and eosinophils and is characterized as a granulocyte-specific activation antigen. CEACAM8 could serve as a marker for granulocyte activities (2). Like all members of the CEA family, it consists of a single N domain, with structural homology to the immunoglobulin variable domains, followed by two immunoglobulin constant-like A and B domains.
 Applications Tested/Suitable for anti-CEACAM8 antibody   

Flow Cytometry (FC/FACS), CELISA, ELISA (EIA)

 Application Notes for anti-CEACAM8 antibody    Flow Cytometry: 1.2 ug/10^6 cells
CELISA: 1:200 - 1:400
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 Testing Data of anti-CEACAM8 antibody    Fig.1: FACS analysis of BOSC23 cells using GM2H6 Cat.# GM- 0512. BOSC23 cells were transiently transfected with an expression vector encoding either CEACAM8 (red curve) or an irrelevant protein (control transfectant). Binding of GM-0512 was detected with a PE-conjugated secondary antibody. A positive signal was obtained only with CEACAM8 transfected cells.
anti-CEACAM8 antibody Testing Data image
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 Testing Data #2 of anti-CEACAM8 antibody    Fig. 2: BOSC23 cells were transiently transfected with expression vectors containing either the cDNA of CEACAM1, CEACAM3-8 or PSG. The latter expressed as a membrane bound fusion protein. Expression of the constructs was tested with monoclonal antibodies known to recognize the corresponding proteins (CEACAM1,3,4,5 and 6: D14HD11; CEACAM7: BAC2; CEACAM8: Tet2; PSG: BAP3; green curves). An irrelevant monoclonal antibody served as a negative control (black curves). For specificity testing, protein G-purified GM-2H6 was tested on all CEACAM transfectants. A positive signal was obtained only with CEACAM8 transfected cells (red curve).
anti-CEACAM8 antibody Testing Data #2 image
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NCBI/Uniprot data below describe general gene information for CEACAM8. It may not necessarily be applicable to this product.
 NCBI GI #    21314600
 NCBI GeneID    1088
 NCBI Accession #    NP_001807.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_001816.3 [Other Products]
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 UniProt Primary Accession #    P31997 [Other Products]
 UniProt Secondary Accession #    O60399; Q16574 [Other Products]
 UniProt Related Accession #    P31997 [Other Products]
 Molecular Weight    38,154 Da [Similar Products]
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 NCBI Official Full Name    carcinoembryonic antigen-related cell adhesion molecule 8
 NCBI Official Synonym Full Names    carcinoembryonic antigen-related cell adhesion molecule 8
 NCBI Official Symbol    CEACAM8 [Similar Products]
 NCBI Official Synonym Symbols   
CD67; CGM6; CD66b; NCA-95
[Similar Products]
 NCBI Protein Information    carcinoembryonic antigen-related cell adhesion molecule 8; CD67 antigen; carcinoembryonic antigen CGM6; non-specific cross-reacting antigen NCA-95; carcinoembryonic antigen gene family member 6
 UniProt Synonym Protein Names   
CD67 antigen; Carcinoembryonic antigen CGM6; Non-specific cross-reacting antigen NCA-95; CD_antigen: CD66b
 Protein Family    Carcinoembryonic antigen-related cell adhesion molecule
 UniProt Gene Name    CEACAM8 [Similar Products]
 UniProt Synonym Gene Names    CGM6 [Similar Products]
 UniProt Entry Name    CEAM8_HUMAN
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 UniProt Comments for CEACAM8    CEACAM8: Belongs to the immunoglobulin superfamily. CEA family.

Protein type: Immunoglobulin superfamily; Membrane protein, integral; Membrane protein, GPI anchor

Chromosomal Location of Human Ortholog: 19q13.2

Cellular Component: extracellular space; integral to plasma membrane; plasma membrane

Biological Process: immune response; blood coagulation; leukocyte migration
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Product References and Citations for anti-CEACAM8 antibody

   1. Zimmermann W (2002). Carcinoembryonic antigen. In Wiley Encyclopedia of Molecular Medicine (T. Creighton, ed.), John Wiley & Sons Inc., New York, USA, pp. 459-462.
2. Zhao L, Xu S, Fjaertoft G, Pauksen K, Hakansson L and Venge P (2004). An enzyme-linked immunosorbent assay for human carcinoembryonic antigen-related cell adhesion molecule 8, a biological marker of granulocyte activities in vivo. J. Immunol. Methods 293(1-2):207-14
Hammarström S (1999). The carcinoembryonic antigen (CEA) family: structures, suggested functions and expression in normal and malignant tissues. Semin. Cancer Biol. 9, 67-81.
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 Research Articles on CEACAM8    1. Granulocytes from type 2 diabetes patients display higher granulocyte cell surface expression of CD66b compared with values of healthy controls.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CEACAM8 antibodyDiseases associated with anti-CEACAM8 antibody
 Reference Product  PubMed Publications
 CEACAM1 antibody  >21 publications with CEACAM8 and CEACAM1
 CEACAM6 antibody  >19 publications with CEACAM8 and CEACAM6
 MPO antibody  >5 publications with CEACAM8 and MPO
 TNF antibody  >2 publications with CEACAM8 and TNF
 LTF antibody  >1 publications with CEACAM8 and LTF
 DEFA4 antibody  >1 publications with CEACAM8 and DEFA4
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >29 publications with CEACAM8 and Inflammation
 Necrosis Antibodies  >6 publications with CEACAM8 and Necrosis
 Heart Diseases Antibodies  >6 publications with CEACAM8 and Heart Diseases
 Lung Diseases Antibodies  >5 publications with CEACAM8 and Lung Diseases
 Atherosclerosis Antibodies  >4 publications with CEACAM8 and Atherosclerosis
 Sepsis Antibodies  >3 publications with CEACAM8 and Sepsis
 Wounds and Injuries Antibodies  >2 publications with CEACAM8 and Wounds and Injuries
 Cell Transformation, Neoplastic Antibodies  >2 publications with CEACAM8 and Cell Transformation, Neoplastic
 Liver Diseases Antibodies  >2 publications with CEACAM8 and Liver Diseases
 Skin Diseases Antibodies  >2 publications with CEACAM8 and Skin Diseases
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