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anti-CFI antibody :: Mouse anti-Human CFI / Complement Factor I Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS245037
Immunohistochemistry (IHC)
Unit / Price
0.125 mg  /  $495 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CFI / Complement Factor I, Monoclonal Antibody

 Also Known As   

Mouse Monoclonal [clone OX-21] (IgG1) to Human CFI / Complement Factor I

 Product Synonym Names    Anti-CFI / Complement Factor I Antibody (clone OX-21) IHC-plus; CFI; AHUS3; C3BINA; C3b-inactivator; C3B/C4B inactivator; Complement component I; Complement component factor i; Factor I; FI; KAF; I factor; I factor (complement); C3b-INA; Complement factor I; Light chain of factor I; Human CFI; Complement Factor I
 Product Gene Name   

anti-CFI antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    phenotype 615439
 3D Structure    ModBase 3D Structure for P05156
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    OX-21
 Host    Mouse
 Species Reactivity    Human
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 Specificity    Purified human Complement Factor 1
 Purity/Purification    Protein G Purified
 Form/Format    PBS, 0.02% sodium azide. Sourced in Ascites.
 Concentration    1 mg/ml (lot specific)
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 Target Species    Human
 Immunogen Description    Human complement factor I
 Immunogen Type    Purified protein
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 Preparation and Storage    Store at 4 degree C for short term applications. For long term storage, aliquot and store at -20 degree C.
 Other Notes    Small volumes of anti-CFI antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-CFI antibody    Family: Protease
Subfamily: Serine S1
 Applications Tested/Suitable for anti-CFI antibody   

Immunohistochemistry (IHC - Paraffin), Western Blot (WB), Immunoprecipitation (IP), Flow Cytometry (FC/FACS), ELISA (EIA)

 Application Notes for anti-CFI antibody    ELISA, Flo, IHC-P (20 ug/ml), IP, WB
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...
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 Immunohistochemistry (IHC) of anti-CFI antibody    Anti-Factor I antibody IHC of human colon, vessels. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 20 ug/ml.
anti-CFI antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for CFI. It may not necessarily be applicable to this product.
 NCBI GI #    119392081
 NCBI GeneID    3426
 NCBI Accession #    NP_000195.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000204.3 [Other Products]
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 UniProt Primary Accession #    P05156 [Other Products]
 UniProt Secondary Accession #    O60442 [Other Products]
 UniProt Related Accession #    P05156 [Other Products]
 Molecular Weight    65,750 Da
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 NCBI Official Full Name    complement factor I preproprotein
 NCBI Official Synonym Full Names    complement factor I
 NCBI Official Symbol    CFI [Similar Products]
 NCBI Official Synonym Symbols   
FI; IF; KAF; AHUS3; ARMD13; C3BINA; C3b-INA
[Similar Products]
 NCBI Protein Information    complement factor I; C3b-inactivator; C3B/C4B inactivator; complement component I; light chain of factor I; Konglutinogen-activating factor; complement factor I heavy chain; complement control protein factor I
 UniProt Protein Name    Complement factor I
 UniProt Synonym Protein Names   
C3B/C4B inactivatorCleaved into the following 2 chains:Complement factor I heavy chain; Complement factor I light chain
 Protein Family    Complement factor
 UniProt Gene Name    CFI [Similar Products]
 UniProt Synonym Gene Names    IF [Similar Products]
 UniProt Entry Name    CFAI_HUMAN
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 NCBI Summary for CFI    This gene encodes a serine proteinase that is essential for regulating the complement cascade. The encoded preproprotein is cleaved to produce both heavy and light chains, which are linked by disulfide bonds to form a heterodimeric glycoprotein. This heterodimer can cleave and inactivate the complement components C4b and C3b, and it prevents the assembly of the C3 and C5 convertase enzymes. Defects in this gene cause complement factor I deficiency, an autosomal recessive disease associated with a susceptibility to pyogenic infections. Mutations in this gene have been associated with a predisposition to atypical hemolytic uraemic syndrome, a disease characterized by acute renal failure, microangiopathic hemolytic anemia and thrombocytopenia. Primary glomerulonephritis with immmune deposits is another condition associated with mutation of this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for CFI    CFI: Responsible for cleaving the alpha-chains of C4b and C3b in the presence of the cofactors C4-binding protein and factor H respectively. Defects in CFI are a cause of susceptibility to hemolytic uremic syndrome atypical type 3 (AHUS3). An atypical form of hemolytic uremic syndrome. It is a complex genetic disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, renal failure and absence of episodes of enterocolitis and diarrhea. In contrast to typical hemolytic uremic syndrome, atypical forms have a poorer prognosis, with higher death rates and frequent progression to end-stage renal disease. Susceptibility to the development of atypical hemolytic uremic syndrome can be conferred by mutations in various components of or regulatory factors in the complement cascade system. Other genes may play a role in modifying the phenotype. Defects in CFI are the cause of complement factor I deficiency (CFI deficiency). CFI deficiency is an autosomal recessive condition associated with a propensity to pyogenic infections. Belongs to the peptidase S1 family.

Protein type: Secreted; Secreted, signal peptide; EC 3.4.21.45; Protease

Chromosomal Location of Human Ortholog: 4q25

Cellular Component: extracellular space; membrane; extracellular region; nucleus

Molecular Function: metal ion binding; serine-type endopeptidase activity; scavenger receptor activity

Biological Process: receptor-mediated endocytosis; regulation of complement activation; innate immune response; proteolysis; complement activation, classical pathway

Disease: Macular Degeneration, Age-related, 13; Complement Factor I Deficiency; Hemolytic Uremic Syndrome, Atypical, Susceptibility To, 3
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 Research Articles on CFI    1. Recurrent aseptic meningo-encephalitis is a rare clinical presentation of complete FI deficiency.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CFI antibodyPathways associated with anti-CFI antibody
 Reference Product  PubMed Publications
 CFH antibody  >62 publications with CFI and CFH
 CD46 antibody  >32 publications with CFI and CD46
 SERPINC1 antibody  >3 publications with CFI and SERPINC1
 CR1 antibody  >2 publications with CFI and CR1
 C4BPA antibody  >2 publications with CFI and C4BPA
 Products by Pathway  Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement Cascade Pathway antibodies  Complement Cascade Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 Regulation Of Complement Cascade Pathway antibodies  Regulation Of Complement Cascade Pathway Diagram
 Staphylococcus Aureus Infection Pathway antibodies  Staphylococcus Aureus Infection Pathway Diagram
 Staphylococcus Aureus Infection Pathway antibodies  Staphylococcus Aureus Infection Pathway Diagram
Diseases associated with anti-CFI antibodyOrgans/Tissues associated with anti-CFI antibody
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >114 publications with CFI and Cardiovascular Diseases
 Heart Diseases Antibodies  >84 publications with CFI and Heart Diseases
 Kidney Diseases Antibodies  >58 publications with CFI and Kidney Diseases
 Anemia Antibodies  >48 publications with CFI and Anemia
 Anemia, Hemolytic Antibodies  >44 publications with CFI and Anemia, Hemolytic
 Brain Diseases Antibodies  >43 publications with CFI and Brain Diseases
 Atypical Hemolytic Uremic Syndrome Antibodies  >42 publications with CFI and Atypical Hemolytic Uremic Syndrome
 Inflammation Antibodies  >35 publications with CFI and Inflammation
 Macular Degeneration Antibodies  >24 publications with CFI and Macular Degeneration
 Hypertension Antibodies  >21 publications with CFI and Hypertension
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >217 publications with CFI and Blood
 Heart Antibodies  >70 publications with CFI and Heart
 Vascular Antibodies  >67 publications with CFI and Vascular
 Brain Antibodies  >50 publications with CFI and Brain
 Kidney Antibodies  >41 publications with CFI and Kidney
 Lung Antibodies  >34 publications with CFI and Lung
 Liver Antibodies  >25 publications with CFI and Liver
 Eye Antibodies  >24 publications with CFI and Eye
 Skin Antibodies  >20 publications with CFI and Skin
 Muscle Antibodies  >13 publications with CFI and Muscle
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