NP_001005271.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
chromodomain-helicase-DNA-binding protein 3 isoform 3
NCBI Official Synonym Full Names
chromodomain helicase DNA binding protein 3
NCBI Protein Information
chromodomain-helicase-DNA-binding protein 3
UniProt Protein Name
Chromodomain-helicase-DNA-binding protein 3
UniProt Synonym Protein Names
ATP-dependent helicase CHD3; Mi-2 autoantigen 240 kDa protein; Mi2-alpha; Zinc finger helicase; hZFH
UniProt Synonym Gene Names
UniProt Entry Name
CHD3_HUMAN
NCBI Summary for CHD3
This gene encodes a member of the CHD family of proteins which are characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. This protein is one of the components of a histone deacetylase complex referred to as the Mi-2/NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromatin remodeling is essential for many processes including transcription. Autoantibodies against this protein are found in a subset of patients with dermatomyositis. Three alternatively spliced transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
UniProt Comments for CHD3
Component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity.
Product References and Citations for anti-CHD3 antibody
Aubry F.,et al.Eur. J. Biochem. 254:558-564(1998). Zody M.C.,et al.Nature 440:1045-1049(2006). Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases. Woodage T.,et al.Proc. Natl. Acad. Sci. U.S.A. 94:11472-11477(1997). Ge Q.,et al.J. Clin. Invest. 96:1730-1737(1995).
Research Articles on CHD3
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Products associated with anti-CHD3 antibody
Pathways associated with anti-CHD3 antibody
Diseases associated with anti-CHD3 antibody
Organs/Tissues associated with anti-CHD3 antibody
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