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anti-CHI3L1 antibody :: Mouse anti-Human CHI3L1 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS200140
Western Blot (WB)
Unit / Price
0.05 mL  /  $240 +1 FREE 8GB USB
0.1 mL  /  $315 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CHI3L1, Monoclonal Antibody

★Popular Item★
 Also Known As   

CHI3L1 antibody

 Product Synonym Names    chitinase 3-like 1 precursor; chitinase 3-like 1 (cartilage glycoprotein-39); GP39; YKL40
 Product Gene Name   

anti-CHI3L1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    M80927 mRNA
 3D Structure    ModBase 3D Structure for P36222
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 Clonality    Monoclonal
 Isotype    IgG2b, k
 Clone Number    AT2C10
 Host    Mouse
 Species Reactivity    Human
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 Purity/Purification    By protein-G affinity chromatography
 Form/Format    Liquid. In phosphate-buffered saline (pH 7.4) with 0.02% Sodium Azide, 10% glycerol.
 Concentration    1mg/ml (lot specific)
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 Antigen Species    Human
 Immunogen    Recombinant human CHI3L1 (22-383aa) purified from E. coli
 Clone Note    Anti-human CHI3L1 mAb, clone AT2C10, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human CHI3L1 protein.
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 Preparation and Storage    Can be stored at 4 degree C.
For long term storage, aliquot and store at -20 degree C.
Avoid repeated freezing and thawing cycles.
 Other Notes    Small volumes of anti-CHI3L1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CHI3L1 antibody

   Chitinase 3-Like-1 (CHI3L1) is a recently discovered human glycoprotein which is related in amino acid sequence to the chitinase protein family, but has no chitinase activity. CHI3L1 is upregulated in a number of cancers and in non-neoplatic disease states characterized by chronic inflammation and tissue remodeling. Its pattern of expression is associated with pathogenic processes related to inflammation, extracellular tissue remodeling, fibrosis and solid carcinomas. CHI3L1 may play an important role in the capacity of cells to respond to and cope with changes in their environment.
 Product Categories/Family for anti-CHI3L1 antibody    Cytoskeleton
 Applications Tested/Suitable for anti-CHI3L1 antibody   

ELISA (EIA), Western Blot (WB) (Cell lysate)

 Application Notes for anti-CHI3L1 antibody    WB: 1:250 ~ 1500.
Recommended starting dilution is 1:250
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 Western Blot (WB) of anti-CHI3L1 antibody    Cell lysates (40ug) were resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human CHI3L1 (1:500). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system. Lane 1.: SW480 cell lysate
anti-CHI3L1 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for CHI3L1. It may not necessarily be applicable to this product.
 NCBI GI #    144226251
 NCBI GeneID    1116
 NCBI Accession #    NP_001267 [Other Products]
 NCBI GenBank Nucleotide #    NM_001276.2 [Other Products]
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 UniProt Primary Accession #    P36222 [Other Products]
 UniProt Secondary Accession #    P30923; Q8IVA4; Q96HI7; B2R7B0 [Other Products]
 UniProt Related Accession #    P36222 [Other Products]
 Molecular Weight    42,625 Da
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 NCBI Official Full Name    chitinase-3-like protein 1
 NCBI Official Synonym Full Names    chitinase 3 like 1
 NCBI Official Symbol    CHI3L1 [Similar Products]
 NCBI Official Synonym Symbols   
GP39; ASRT7; GP-39; YKL40; CGP-39; YKL-40; YYL-40; HC-gp39; HCGP-3P; hCGP-39
[Similar Products]
 NCBI Protein Information    chitinase-3-like protein 1
 UniProt Protein Name    Chitinase-3-like protein 1
 UniProt Synonym Protein Names   
39 kDa synovial protein; Cartilage glycoprotein 39; CGP-39; GP-39; hCGP-39; YKL-40
 Protein Family    Chitinase-3-like protein
 UniProt Gene Name    CHI3L1 [Similar Products]
 UniProt Synonym Gene Names    CGP-39; GP-39; hCGP-39 [Similar Products]
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 NCBI Summary for CHI3L1    Chitinases catalyze the hydrolysis of chitin, which is an abundant glycopolymer found in insect exoskeletons and fungal cell walls. The glycoside hydrolase 18 family of chitinases includes eight human family members. This gene encodes a glycoprotein member of the glycosyl hydrolase 18 family. The protein lacks chitinase activity and is secreted by activated macrophages, chondrocytes, neutrophils and synovial cells. The protein is thought to play a role in the process of inflammation and tissue remodeling. [provided by RefSeq, Sep 2009]
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 UniProt Comments for CHI3L1    Carbohydrate-binding lectin with a preference for chitin. Has no chitinase activity. May play a role in tissue remodeling and in the capacity of cells to respond to and cope with changes in their environment. Plays a role in T-helper cell type 2 (Th2) inflammatory response and IL-13-induced inflammation, regulating allergen sensitization, inflammatory cell apoptosis, dendritic cell accumulation and M2 macrophage differentiation. Facilitates invasion of pathogenic enteric bacteria into colonic mucosa and lymphoid organs. Mediates activation of AKT1 signaling pathway and subsequent IL8 production in colonic epithelial cells. Regulates antibacterial responses in lung by contributing to macrophage bacterial killing, controlling bacterial dissemination and augmenting host tolerance. Also regulates hyperoxia-induced injury, inflammation and epithelial apoptosis in lung.
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Product References and Citations for anti-CHI3L1 antibody

   Kazakova MH, et al., (2009) Folia Med. 51 (1):5-14; Bonneh-Barkay D, et al., (2008) Am J Pathol. 173 (1):130-43
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 Research Articles on CHI3L1    1. YKL-40 induces IL-18 production in osteoblasts and thereby stimulates angiogenesis of endothelial progenitor cells through the suppression of miR-590-3p via the focal adhesion kinase (FAK)/PI3K/Akt signaling pathway.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CHI3L1 antibodyPathways associated with anti-CHI3L1 antibody
 Reference Product  PubMed Publications
 TNF antibody  >48 publications with CHI3L1 and TNF
 MMP9 antibody  >13 publications with CHI3L1 and MMP9
 VEGFA antibody  >8 publications with CHI3L1 and VEGFA
 CHID1 antibody  >4 publications with CHI3L1 and CHID1
 Products by Pathway  Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 Neutrophil Degranulation Pathway antibodies  Neutrophil Degranulation Pathway Diagram
Diseases associated with anti-CHI3L1 antibodyOrgans/Tissues associated with anti-CHI3L1 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >311 publications with CHI3L1 and Inflammation
 Lung Diseases Antibodies  >137 publications with CHI3L1 and Lung Diseases
 Brain Diseases Antibodies  >105 publications with CHI3L1 and Brain Diseases
 Fibrosis Antibodies  >79 publications with CHI3L1 and Fibrosis
 Glioma Antibodies  >68 publications with CHI3L1 and Glioma
 Glioblastoma Antibodies  >63 publications with CHI3L1 and Glioblastoma
 Heart Diseases Antibodies  >57 publications with CHI3L1 and Heart Diseases
 Necrosis Antibodies  >55 publications with CHI3L1 and Necrosis
 Liver Diseases Antibodies  >55 publications with CHI3L1 and Liver Diseases
 Osteoarthritis Antibodies  >52 publications with CHI3L1 and Osteoarthritis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >507 publications with CHI3L1 and Blood
 Lung Antibodies  >121 publications with CHI3L1 and Lung
 Brain Antibodies  >114 publications with CHI3L1 and Brain
 Liver Antibodies  >68 publications with CHI3L1 and Liver
 Bone Antibodies  >61 publications with CHI3L1 and Bone
 Connective Tissue Antibodies  >58 publications with CHI3L1 and Connective Tissue
 Kidney Antibodies  >26 publications with CHI3L1 and Kidney
 Skin Antibodies  >25 publications with CHI3L1 and Skin
 Intestine Antibodies  >21 publications with CHI3L1 and Intestine
 Lymph Node Antibodies  >17 publications with CHI3L1 and Lymph Node
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