AAH06437.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
CHTF18 protein, partial
NCBI Official Synonym Full Names
CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae)
NCBI Official Synonym Symbols
CHL12; Ctf18; RUVBL; C16orf41; C321D2.2; C321D2.3; C321D2.4 [Similar Products]
NCBI Protein Information
chromosome transmission fidelity protein 18 homolog; hCTF18; homolog of yeast CHL12; C321D2.3 (novel protein); C321D2.4 (novel protein); some homology with holliday junction DNA helicase RUVB like
UniProt Protein Name
Chromosome transmission fidelity protein 18 homolog
UniProt Synonym Protein Names
CHL12
UniProt Synonym Gene Names
UniProt Entry Name
CTF18_HUMAN
NCBI Summary for CHTF18
CHTF18, CHTF8 (MIM 613202), and DCC1 (DSCC1; MIM 613203) are components of an alternative replication factor C (RFC) (see MIM 600404) complex that loads PCNA (MIM 176740) onto DNA during S phase of the cell cycle (Merkle et al., 2003 [PubMed 12766176]; Bermudez et al., 2003 [PubMed 12930902]).[supplied by OMIM, Dec 2009]
UniProt Comments for CHTF18
CTF18: Chromosome cohesion factor involved in sister chromatid cohesion and fidelity of chromosome transmission. Component of one of the cell nuclear antigen loader complexes, CTF18-replication factor C (CTF18-RFC), which consists of CTF18, CTF8, DCC1, RFC2, RFC3, RFC4 and RFC5. The CTF18-RFC complex binds to single- stranded and primed DNAs and has weak ATPase activity that is stimulated by the presence of primed DNA, replication protein A (RPA) and by proliferating cell nuclear antigen (PCNA). The CTF18- RFC complex catalyzes the ATP-dependent loading of PCNA onto primed and gapped DNA. It also interacts with and stimulates DNA polymerase POLH. Belongs to the activator 1 small subunits family. CTF18 subfamily. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: DNA replication
Chromosomal Location of Human Ortholog: 16p13.3
Cellular Component: nucleoplasm; membrane; cytoplasm
Molecular Function: DNA binding; ATP binding
Biological Process: negative regulation of chromosome segregation; meiotic recombination; spermatogenesis; DNA replication; male meiosis
Research Articles on CHTF18
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Products associated with anti-CHTF18 antibody
Pathways associated with anti-CHTF18 antibody
Organs/Tissues associated with anti-CHTF18 antibody
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