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anti-CLNS1A antibody :: Mouse anti-Human CLNS1A Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS120273
Unit / Price
0.1 mg  /  $345 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CLNS1A, Monoclonal Antibody

★Popular Item★
 Also Known As   

Mouse monoclonal antibody Anti-Human CLNS1A

 Product Synonym Names    Homo sapiens chloride channel, nucleotide-sensitive, 1A (CLNS1A); CLCI; ICln; CLNS1B
 Product Gene Name   

anti-CLNS1A antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    602158
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    2187C2a
 Host    Mouse
 Species Reactivity    Human
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 Concentration    100 ug/ml (1.0 ml) (lot specific)
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 Preparation    This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.
 Sterility    Filtered through a 0.22 um membrane.
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 Other Notes    Small volumes of anti-CLNS1A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-CLNS1A antibody

   The interaction with Sm proteins inhibits their assembly on U RNA and interferes with snRNP biogenesis. Inhibits the binding of survival motor neuron protein (SMN) to Sm proteins. May participate in cellular volume control by activation of a swelling-induced chloride conductance pathway. [UniProtKB Function]
 Applications Tested/Suitable for anti-CLNS1A antibody   

Dot Blot (DB), Immunocytochemistry (ICC), Western Blot (WB)

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 Quality Control of anti-CLNS1A antibody    Western blot analysis of immunized recombinant protein, using anti-CLNS1A monoclonal antibody.
anti-CLNS1A antibody Quality Control image
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 Quality Control #2 of anti-CLNS1A antibody    Arrow indicates the region of immunized recombinant protein carrying 50-200 amino acids.
anti-CLNS1A antibody Quality Control #2 image
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 Western Blot (WB) of anti-CLNS1A antibody    Detection of CLNS1A by Western blot.

Samples: Whole cell lysate from human HEK293 (H, 25 ug), mouse NIH3T3 (M, 25 ug) and rat F2408 (R, 25 ug) cells. [Lot No. 2187C2a-1]

Predicted molecular weight: 26 kDa
anti-CLNS1A antibody Western Blot (WB) (WB) image
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 Immunocytochemistry (ICC) of anti-CLNS1A antibody    Immunostaining analysis in HeLa cells. HeLa cells were fixed with 4% paraformaldehyde and permeabilized with 0.1% Triton X-100 in PBS. The cells were immunostained with anti-CLNS1A mAb. [Lot No. 2187C2a-1]
anti-CLNS1A antibody Immunocytochemistry (ICC) (ICC) image
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NCBI/Uniprot data below describe general gene information for CLNS1A. It may not necessarily be applicable to this product.
 NCBI GI #    222418789
 NCBI GeneID    1207
 NCBI Accession #    NP_001284.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001293 [Other Products]
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 UniProt Secondary Accession #    Q0VDK6; Q9NRD2; Q9NRD3; B2RCS9 [Other Products]
 UniProt Related Accession #    P54105 [Other Products]
 Molecular Weight    26,215 Da
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 NCBI Official Full Name    Homo sapiens chloride channel, nucleotide-sensitive, 1A (CLNS1A), mRNA
 NCBI Official Synonym Full Names    chloride channel, nucleotide-sensitive, 1A
 NCBI Official Symbol    CLNS1A [Similar Products]
 NCBI Official Synonym Symbols   
CLCI; ICln; CLNS1B
[Similar Products]
 NCBI Protein Information    methylosome subunit pICln; chloride channel regulatory protein; chloride channel, nucleotide sensitive 1A; chloride conductance regulatory protein ICln; chloride ion current inducer protein; i(Cln); reticulocyte pICln; reticulocyte protein ICln
 UniProt Protein Name    Methylosome subunit pICln
 UniProt Synonym Protein Names   
Chloride channel, nucleotide sensitive 1A; Chloride conductance regulatory protein ICln; I(Cln); Chloride ion current inducer protein; ClCI; Reticulocyte pICln
 UniProt Gene Name    CLNS1A [Similar Products]
 UniProt Entry Name    ICLN_HUMAN
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 NCBI Summary for CLNS1A    This gene encodes a protein that functions in multiple regulatory pathways. The encoded protein complexes with numerous cytosolic proteins and performs diverse functions including regulation of small nuclear ribonucleoprotein biosynthesis, platelet activation and cytoskeletal organization. The protein is also found associated with the plasma membrane where it functions as a chloride current regulator. Pseudogenes of this gene are found on chromosomes 1, 4 and 6. [provided by RefSeq, Feb 2009]
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 UniProt Comments for CLNS1A    ICLN: The interaction with Sm proteins inhibits their assembly on U RNA and interferes with snRNP biogenesis. Inhibits the binding of survival motor neuron protein (SMN) to Sm proteins. May participate in cellular volume control by activation of a swelling-induced chloride conductance pathway. Belongs to the pICln (TC 1.A.47) family.

Protein type: Channel, chloride

Chromosomal Location of Human Ortholog: 11q13.5-q14

Cellular Component: nucleoplasm; cytoskeleton; cytoplasm; plasma membrane; nucleus; cytosol

Molecular Function: protein binding

Biological Process: spliceosomal snRNP biogenesis; chloride transport; gene expression; cell volume homeostasis
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 Research Articles on CLNS1A    1. the S. pombe ICln protein is required for optimal production of the spliceosomal snRNPs and for efficient splicing in vivo
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CLNS1A antibodyPathways associated with anti-CLNS1A antibody
 Reference Product  PubMed Publications
 PRMT5 antibody  >5 publications with CLNS1A and PRMT5
 SNRPN antibody  >2 publications with CLNS1A and SNRPN
 SNRPF antibody  >2 publications with CLNS1A and SNRPF
 Products by Pathway  Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Metabolism Of Non-coding RNA Pathway antibodies  Metabolism Of Non-coding RNA Pathway Diagram
 RNA Transport Pathway antibodies  RNA Transport Pathway Diagram
 RNA Transport Pathway antibodies  RNA Transport Pathway Diagram
 SnRNP Assembly Pathway antibodies  SnRNP Assembly Pathway Diagram
Diseases associated with anti-CLNS1A antibodyOrgans/Tissues associated with anti-CLNS1A antibody
 Disease Name  Pubmed Publications
 Infertility, Female Antibodies  >1 publications with CLNS1A and Infertility, Female
 Neoplasms, Experimental Antibodies  >1 publications with CLNS1A and Neoplasms, Experimental
 Breast Neoplasms Antibodies  >1 publications with CLNS1A and Breast Neoplasms
 Cardiovascular Diseases Antibodies  >1 publications with CLNS1A and Cardiovascular Diseases
 Infertility, Male Antibodies  >1 publications with CLNS1A and Infertility, Male
 Kidney Diseases Antibodies  >1 publications with CLNS1A and Kidney Diseases
 Necrosis Antibodies  >1 publications with CLNS1A and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >8 publications with CLNS1A and Kidney
 Blood Antibodies  >8 publications with CLNS1A and Blood
 Eye Antibodies  >3 publications with CLNS1A and Eye
 Heart Antibodies  >3 publications with CLNS1A and Heart
 Muscle Antibodies  >3 publications with CLNS1A and Muscle
 Brain Antibodies  >3 publications with CLNS1A and Brain
 Testis Antibodies  >2 publications with CLNS1A and Testis
 Liver Antibodies  >2 publications with CLNS1A and Liver
 Stomach Antibodies  >1 publications with CLNS1A and Stomach
 Spleen Antibodies  >1 publications with CLNS1A and Spleen
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