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anti-CNOT6 antibody :: Mouse anti-Human CNOT6 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS120316
Unit / Price
0.1 mg  /  $345 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CNOT6, Monoclonal Antibody

 Also Known As   

Mouse monoclonal antibody Anti-Human CNOT6

 Product Synonym Names    Homo sapiens CCR4-NOT transcription complex, subunit 6; CCR4; KIAA1194
 Product Gene Name   

anti-CNOT6 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    608951
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 Clonality    Monoclonal
 Isotype    IgG2b
 Clone Number    2193C2a
 Host    Mouse
 Species Reactivity    Human
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 Concentration    100 ug/ml (1.0 ml) (lot specific)
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 Preparation    This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.
 Sterility    Filtered through a 0.22 um membrane.
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 Other Notes    Small volumes of anti-CNOT6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CNOT6 antibody

   The protein encoded by this gene is a subunit of the CCR4-NOT core transcriptional regulation complex. The encoded protein has a 3'-5' RNase activity and prefers polyadenylated substates. [NCBI Entrez Gene Summary]
 Applications Tested/Suitable for anti-CNOT6 antibody   

Dot Blot (DB)

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 Quality Control of anti-CNOT6 antibody    Western blot analysis of immunized recombinant protein, using anti-CNOT6 monoclonal antibody.
anti-CNOT6 antibody Quality Control image
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 Quality Control #2 of anti-CNOT6 antibody    Arrow indicates the region of immunized recombinant protein carrying 50-200 amino acids.
anti-CNOT6 antibody Quality Control #2 image
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NCBI/Uniprot data below describe general gene information for CNOT6. It may not necessarily be applicable to this product.
 NCBI GI #    53829366
 NCBI GeneID    57472
 NCBI Accession #    NP_056270.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_015455 [Other Products]
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 UniProt Secondary Accession #    A7MD46; D3DWR0 [Other Products]
 UniProt Related Accession #    Q9ULM6 [Other Products]
 Molecular Weight    63,307 Da
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 NCBI Official Synonym Full Names    CCR4-NOT transcription complex, subunit 6
 NCBI Official Symbol    CNOT6 [Similar Products]
 NCBI Official Synonym Symbols   
CCR4; Ccr4a
[Similar Products]
 NCBI Protein Information    CCR4-NOT transcription complex subunit 6
 UniProt Protein Name    CCR4-NOT transcription complex subunit 6
 UniProt Synonym Protein Names   
CCR4 carbon catabolite repression 4-like; Carbon catabolite repressor protein 4 homolog; Cytoplasmic deadenylase
 Protein Family    CCR4-NOT transcription complex
 UniProt Gene Name    CNOT6 [Similar Products]
 UniProt Entry Name    CNOT6_HUMAN
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 NCBI Summary for CNOT6    This gene encodes the catalytic component of the CCR4-NOT core transcriptional regulation complex. The encoded protein has a 3'-5' RNase activity and prefers polyadenylated substrates. The CCR4-NOT complex plays a role in many cellular processes, including miRNA-mediated repression, mRNA degradation, and transcriptional regulation. [provided by RefSeq, Dec 2014]
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 UniProt Comments for CNOT6    CNOT6: Poly(A) nuclease involved in mRNA decay mediated by the major-protein-coding determinant of instability (mCRD) of the FOS gene in the cytoplasm. Has 3'-5' RNase activity. The CCR4-NOT complex functions as general transcription regulation complex. In the presence of ZNF335, enhances ligand-dependent transcriptional activity of nuclear hormone receptors, including RARA. The increase of ligand-dependent ESR1-mediated transcription is much smaller, if any. Belongs to the CCR4/nocturin family.

Protein type: Hydrolase; EC 3.1.13.4

Chromosomal Location of Human Ortholog: 5q35.3

Cellular Component: membrane; cytosol; nucleus; CCR4-NOT complex

Molecular Function: protein binding; poly(A)-specific ribonuclease activity; exoribonuclease activity; RNA binding; metal ion binding

Biological Process: regulation of translation; poly(A) tail shortening; transcription, DNA-dependent; regulation of transcription, DNA-dependent; positive regulation of cell proliferation; gene expression; miRNA-mediated gene silencing; mRNA catabolic process, deadenylation-dependent decay
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 Research Articles on CNOT6    1. Results identified CNOT6/CNOT6L as a key regulator of insulin-like growth factor-binding protein 5, which mediates cell cycle arrest and senescence via a p53-dependent pathway.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CNOT6 antibodyPathways associated with anti-CNOT6 antibody
 Reference Product  PubMed Publications
 CNOT7 antibody  >6 publications with CNOT6 and CNOT7
 CNOT1 antibody  >5 publications with CNOT6 and CNOT1
 CNOT8 antibody  >5 publications with CNOT6 and CNOT8
 CNOT3 antibody  >2 publications with CNOT6 and CNOT3
 CNOT2 antibody  >2 publications with CNOT6 and CNOT2
 RQCD1 antibody  >1 publications with CNOT6 and RQCD1
 Products by Pathway  Pathway Diagram
 Deadenylation Of MRNA Pathway antibodies  Deadenylation Of MRNA Pathway Diagram
 Deadenylation-dependent MRNA Decay Pathway antibodies  Deadenylation-dependent MRNA Decay Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 RNA Degradation Pathway antibodies  RNA Degradation Pathway Diagram
 RNA Degradation Pathway antibodies  RNA Degradation Pathway Diagram
Diseases associated with anti-CNOT6 antibodyOrgans/Tissues associated with anti-CNOT6 antibody
 Disease Name  Pubmed Publications
 Abnormalities, Multiple Antibodies  >1 publications with CNOT6 and Abnormalities, Multiple
 Abnormalities, Drug-Induced Antibodies  >1 publications with CNOT6 and Abnormalities, Drug-Induced
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >1 publications with CNOT6 and Bone
 Eye Antibodies  >1 publications with CNOT6 and Eye
 Brain Antibodies  >1 publications with CNOT6 and Brain
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