NP_056271.2
[Other Products]
NCBI GenBank Nucleotide #
|
[Other Products]
UniProt Primary Accession #
|
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
negative elongation factor B
NCBI Official Synonym Full Names
negative elongation factor complex member B
NCBI Protein Information
negative elongation factor B; cofactor of BRCA1; negative elongation factor protein B
UniProt Protein Name
Negative elongation factor B
UniProt Synonym Protein Names
Cofactor of BRCA1
UniProt Synonym Gene Names
UniProt Entry Name
NELFB_HUMAN
NCBI Summary for COBRA1
NELFB is a subunit of negative elongation factor (NELF), which also includes NELFA (WHSC2; MIM 606026), either NELFC or NELFD (TH1L; MIM 605297), and NELFE (RDBP; MIM 154040). NELF acts with DRB sensitivity-inducing factor (DSIF), a heterodimer of SPT4 (SUPT4H1; MIM 603555) and SPT5 (SUPT5H; MIM 602102), to cause transcriptional pausing of RNA polymerase II (see MIM 180660) (Narita et al., 2003 [PubMed 12612062]).[supplied by OMIM, Mar 2008]
UniProt Comments for COBRA1
Function: Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex. May be able to induce chromatin unfolding. Ref.7 Ref.8
Subunit structure: The NELF complex is composed of NELFA, NELFB, NELFCD (isoform NELF-Cor isoform NELF-D)and NELFE. Interacts with the first BRCT repeat of BRCA1. Interacts with KIAA1191. Ref.1 Ref.7 Ref.15
Subcellular location: Nucleus Ref.1.
Tissue specificity: Widely expressed. Expressed in heart, brain, lung, placenta, liver, skeletal muscle, kidney and pancreas. Ref.7
Sequence similarities: Belongs to the NELF-B family.
Sequence caution: The sequence AAH11892.1 differs from that shown. Reason: Erroneous initiation. The sequence BAB14157.1 differs from that shown. Reason: Erroneous initiation. The sequence CAB43381.3 differs from that shown. Reason: Erroneous initiation.
Product References and Citations for anti-COBRA1 antibody
• Aiyar, SE, Sun J, Blair AL, Moskaluk CA, Lu Y, Ye Q, Yamaguchi Y, Mukherjee A, Ren D, Handa H, Li R (2004). Attenuation of estrogen receptor alpha-mediated transcription through estrogen-stimulated recruitment of a negative elongation factor. Genes Dev. 18 (17): 2134- 46. • Zhong, H, Zhu J, Zhang H, Ding L, Sun Y, Huang C, Ye Qi (2004). COBRA1 inhibits AP-1 transcriptional activity in transfected cells. Biochem. Biophys. Res. Commun.325 (2): 568- 73.
Research Articles on COBRA1
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Pathways associated with anti-COBRA1 antibody
|