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anti-CR2 antibody :: Mouse anti-Human CR2 / CD21 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS246297
Immunohistochemistry (IHC)
Unit / Price
0.125 mL  /  $530 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CR2 / CD21, Monoclonal Antibody

 Also Known As   

Mouse Monoclonal [clone 2G9] (IgG2a) to Human CR2 / CD21

 Product Synonym Names    Anti-CR2 / CD21 Antibody (clone 2G9) IHC-plus; CR2; C3DR; CD21 antigen; CVID7; Complement receptors type 2; CD21; Complement C3d receptor; EBV receptor; SLEB9; Complement receptor type 2; CR; Epstein-Barr virus receptor; Human CR2; CD21
 Product Gene Name   

anti-CR2 antibody

[Similar Products]
 Product Synonym Gene Name    CD21 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    phenotype 614699
 3D Structure    ModBase 3D Structure for P20023
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 Clonality    Monoclonal
 Isotype    IgG2a
 Clone Number    2G9
 Host    Mouse
 Species Reactivity    Human
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 Specificity    Extracellular domain
 Form/Format    0.09% sodium azide. Tissue Culture Supernatant
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 Target Species    Human
 Immunogen Description    Recombinant protein encoding the external domain of human CD21.
 Immunogen Type    Recombinant protein
 Immunogen    CR2 / CD21 antibody was raised against recombinant protein encoding the external domain of human CD21.
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 Preparation and Storage    Stable for 24 months when stored at 2-8 degree C.
 Other Notes    Small volumes of anti-CR2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-CR2 antibody   

Immunohistochemistry (IHC - Paraffin)

 Application Notes for anti-CR2 antibody    IHC-P (1:50)
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 Immunohistochemistry (IHC) of anti-CR2 antibody    Anti-CR2 / CD21 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:50.
anti-CR2 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for CR2. It may not necessarily be applicable to this product.
 NCBI GI #    42544177
 NCBI GeneID    1380
 NCBI Accession #    NP_001868.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_001877.4 [Other Products]
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 UniProt Primary Accession #    P20023 [Other Products]
 UniProt Secondary Accession #    Q13866; Q14212; Q53EL2; Q5BKT9; Q5SR46; Q5SR48; C9JHD2 [Other Products]
 UniProt Related Accession #    P20023 [Other Products]
 Molecular Weight    118,279 Da
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 NCBI Official Full Name    complement receptor type 2 isoform 2
 NCBI Official Synonym Full Names    complement component (3d/Epstein Barr virus) receptor 2
 NCBI Official Symbol    CR2 [Similar Products]
 NCBI Official Synonym Symbols   
CR; C3DR; CD21; CVID7; SLEB9
[Similar Products]
 NCBI Protein Information    complement receptor type 2; EBV receptor; complement C3d receptor
 UniProt Protein Name    Complement receptor type 2
 UniProt Synonym Protein Names   
Complement C3d receptor; Epstein-Barr virus receptor; EBV receptor; CD_antigen: CD21
 Protein Family    Complement receptor
 UniProt Gene Name    CR2 [Similar Products]
 UniProt Synonym Gene Names    C3DR; Cr2; EBV receptor [Similar Products]
 UniProt Entry Name    CR2_HUMAN
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 NCBI Summary for CR2    This gene encodes a membrane protein, which functions as a receptor for Epstein-Barr virus (EBV) binding on B and T lymphocytes. Genetic variations in this gene are associated with susceptibility to systemic lupus erythematosus type 9 (SLEB9). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]
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 UniProt Comments for CR2    CR2: Receptor for complement C3Dd, for the Epstein-Barr virus on human B-cells and T-cells and for HNRPU. Participates in B lymphocytes activation. Genetic variations in CR2 are associated with susceptibility to systemic lupus erythematosus type 9 (SLEB9). Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with a complex genetic basis. SLE is an inflammatory, and often febrile multisystemic disorder of connective tissue characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system. Defects in CR2 are the cause of immunodeficiency, common variable, type 7 (CVID7). A primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B cells is usually in the normal range, but can be low. Belongs to the receptors of complement activation (RCA) family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 1q32

Cellular Component: integral to membrane; plasma membrane; receptor complex; external side of plasma membrane

Molecular Function: complement binding; protein homodimerization activity; complement receptor activity; transmembrane receptor activity; DNA binding

Biological Process: B cell proliferation; complement receptor mediated signaling pathway; B cell differentiation; innate immune response; immune response; complement activation, classical pathway

Disease: Systemic Lupus Erythematosus, Susceptibility To, 9; Immunodeficiency, Common Variable, 2; Immunodeficiency, Common Variable, 7
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 Research Articles on CR2    1. Authors show that expression of the Epstein-Barr virus B-cell attachment receptor, CD21, in B cells that lack this receptor results in significant changes in gene expression, both before and rapidly following EBV-CD21 interaction.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CR2 antibodyPathways associated with anti-CR2 antibody
 Reference Product  PubMed Publications
 CR1 antibody  >561 publications with CR2 and CR1
 CD19 antibody  >75 publications with CR2 and CD19
 CD81 antibody  >16 publications with CR2 and CD81
 IFNA17 antibody  >9 publications with CR2 and IFNA17
 NR5A2 antibody  >1 publications with CR2 and NR5A2
 Products by Pathway  Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Epstein-Barr Virus Infection Pathway antibodies  Epstein-Barr Virus Infection Pathway Diagram
 Epstein-Barr Virus Infection Pathway antibodies  Epstein-Barr Virus Infection Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
Diseases associated with anti-CR2 antibodyOrgans/Tissues associated with anti-CR2 antibody
 Disease Name  Pubmed Publications
 Neoplasms, Experimental Antibodies  >60 publications with CR2 and Neoplasms, Experimental
 Inflammation Antibodies  >52 publications with CR2 and Inflammation
 Disease Models, Animal Antibodies  >46 publications with CR2 and Disease Models, Animal
 Lupus Erythematosus, Systemic Antibodies  >43 publications with CR2 and Lupus Erythematosus, Systemic
 Cell Transformation, Neoplastic Antibodies  >42 publications with CR2 and Cell Transformation, Neoplastic
 Necrosis Antibodies  >31 publications with CR2 and Necrosis
 Kidney Diseases Antibodies  >19 publications with CR2 and Kidney Diseases
 Liver Diseases Antibodies  >17 publications with CR2 and Liver Diseases
 Lung Diseases Antibodies  >15 publications with CR2 and Lung Diseases
 Brain Diseases Antibodies  >14 publications with CR2 and Brain Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >646 publications with CR2 and Blood
 Spleen Antibodies  >64 publications with CR2 and Spleen
 Kidney Antibodies  >50 publications with CR2 and Kidney
 Lymph Node Antibodies  >45 publications with CR2 and Lymph Node
 Liver Antibodies  >34 publications with CR2 and Liver
 Brain Antibodies  >31 publications with CR2 and Brain
 Tonsil Antibodies  >25 publications with CR2 and Tonsil
 Lymph Antibodies  >24 publications with CR2 and Lymph
 Vascular Antibodies  >22 publications with CR2 and Vascular
 Thymus Antibodies  >18 publications with CR2 and Thymus
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