NP_005198.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
Observed: 39 kDa Predicted: 34 kDa
NCBI Official Full Name
crk-like protein
NCBI Official Synonym Full Names
CRK like proto-oncogene, adaptor protein
NCBI Protein Information
crk-like protein
UniProt Protein Name
Crk-like protein
NCBI Summary for CRKL
This gene encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase, plays a role in fibroblast transformation by BCR-ABL, and may be oncogenic.[provided by RefSeq, Jan 2009]
UniProt Comments for CRKL
May mediate the transduction of intracellular signals.
Research Articles on CRKL
Precautions
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Disclaimer
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Products associated with anti-CRKL antibody
Pathways associated with anti-CRKL antibody
Diseases associated with anti-CRKL antibody
Disease Name |
Pubmed Publications |
Neoplasms Antibodies |
>142 publications with CRKL and Neoplasms |
Leukemia, Myelogenous, Chronic, BCR-ABL Positive Antibodies |
>83 publications with CRKL and Leukemia, Myelogenous, Chronic, BCR-ABL Positive |
Heart Defects, Congenital Antibodies |
>12 publications with CRKL and Heart Defects, Congenital |
Disease Models, Animal Antibodies |
>11 publications with CRKL and Disease Models, Animal |
Leukemia, Myeloid, Acute Antibodies |
>11 publications with CRKL and Leukemia, Myeloid, Acute |
Craniofacial Abnormalities Antibodies |
>10 publications with CRKL and Craniofacial Abnormalities |
DiGeorge Syndrome Antibodies |
>10 publications with CRKL and DiGeorge Syndrome |
Neoplasms, Experimental Antibodies |
>7 publications with CRKL and Neoplasms, Experimental |
Breast Neoplasms Antibodies |
>5 publications with CRKL and Breast Neoplasms |
Inflammation Antibodies |
>4 publications with CRKL and Inflammation |
Organs/Tissues associated with anti-CRKL antibody
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