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anti-CRSP2 antibody :: Mouse anti-Human CRSP2 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS120156
Unit / Price
0.1 mg  /  $345 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CRSP2, Monoclonal Antibody

★Popular Item★
 Also Known As   

Mouse monoclonal antibody Anti-Human CRSP2

 Product Synonym Names    Homo sapiens cofactor required for Sp1 transcriptional activation,?subunit 2, 150kDa (CRSP2); CSRP; RGR1;EXLM1; MED14; CXorf4; CRSP150; DRIP150; TRAP170;MGC104513
 Product Gene Name   

anti-CRSP2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    300182
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    2214C1a
 Host    Mouse
 Species Reactivity    Human
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 Concentration    100 ug/ml (1.0 ml) (lot specific)
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 Preparation    This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.
 Sterility    Filtered through a 0.22 um membrane.
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 Other Notes    Small volumes of anti-CRSP2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CRSP2 antibody

   The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. This protein contains a bipartite nuclear localization signal. This gene is known to escape chromosome X-inactivation. [NCBI Entrez Gene Summary]
 Applications Tested/Suitable for anti-CRSP2 antibody   

Dot Blot (DB)

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 Quality Control of anti-CRSP2 antibody    Western blot analysis of immunized recombinant protein, using anti-CRSP2 monoclonal antibody.
anti-CRSP2 antibody Quality Control image
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 Quality Control #2 of anti-CRSP2 antibody    Arrow indicates the region of immunized recombinant protein carrying 50-200 amino acids.
anti-CRSP2 antibody Quality Control #2 image
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NCBI/Uniprot data below describe general gene information for CRSP2. It may not necessarily be applicable to this product.
 NCBI GI #    154813206
 NCBI GeneID    9282
 NCBI Accession #    NP_004220.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_004229 [Other Products]
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 UniProt Secondary Accession #    Q4KMR7; Q9UNB3 [Other Products]
 UniProt Related Accession #    O60244 [Other Products]
 Molecular Weight    160,607 Da
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 NCBI Official Full Name    Homo sapiens mediator complex subunit 14 (MED14), mRNA
 NCBI Official Synonym Full Names    mediator complex subunit 14
 NCBI Official Symbol    MED14 [Similar Products]
 NCBI Official Synonym Symbols   
CSRP; RGR1; CRSP2; EXLM1; CXorf4; CRSP150; DRIP150; TRAP170
[Similar Products]
 NCBI Protein Information    mediator of RNA polymerase II transcription subunit 14; ARC150; CRSP complex subunit 2; RGR1 homolog; activator-recruited cofactor 150 kDa component; cofactor required for Sp1 transcriptional activation, subunit 2 (150kD); hRGR1; human homolog of yeast RGR1; thyroid hormone receptor-associated protein complex 170 kDa component; thyroid hormone receptor-associated protein complex component TRAP170; transcriptional co-activator CRSP150; vitamin D receptor-interacting protein complex component DRIP150; vitamin D3 receptor-interacting protein complex 150 kDa component
 UniProt Protein Name    Mediator of RNA polymerase II transcription subunit 14
 UniProt Synonym Protein Names   
Activator-recruited cofactor 150 kDa component; ARC150; Cofactor required for Sp1 transcriptional activation subunit 2; CRSP complex subunit 2; Mediator complex subunit 14; RGR1 homolog; hRGR1; Thyroid hormone receptor-associated protein complex 170 kDa component; Trap170; Transcriptional coactivator CRSP150; Vitamin D3 receptor-interacting protein complex 150 kDa component; DRIP150
 Protein Family    Calcitonin receptor-stimulating peptide
 UniProt Gene Name    MED14 [Similar Products]
 UniProt Entry Name    MED14_HUMAN
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 NCBI Summary for CRSP2    The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. This protein contains a bipartite nuclear localization signal. This gene is known to escape chromosome X-inactivation. [provided by RefSeq, Jul 2008]
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 UniProt Comments for CRSP2    Trap170: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Belongs to the Mediator complex subunit 14 family.

Protein type: Transcription, coactivator/corepressor; Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: Xp11.4

Cellular Component: nucleoplasm; membrane; Srb-mediator complex; nucleus

Molecular Function: protein binding; ligand-dependent nuclear receptor transcription coactivator activity; vitamin D receptor binding; transcription coactivator activity; transcription cofactor activity; thyroid hormone receptor binding; receptor activity

Biological Process: steroid hormone receptor signaling pathway; regulation of transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; androgen receptor signaling pathway; stem cell maintenance; positive regulation of transcription from RNA polymerase II promoter; gene expression
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 Research Articles on CRSP2    1. This results from a dramatically enhanced ability of MED14-containing complexes to associate with Pol II.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CRSP2 antibodyPathways associated with anti-CRSP2 antibody
 Reference Product  PubMed Publications
 MED23 antibody  >5 publications with CRSP2 and MED23
 MED1 antibody  >5 publications with CRSP2 and MED1
 CDK8 antibody  >5 publications with CRSP2 and CDK8
 MED7 antibody  >4 publications with CRSP2 and MED7
 MED15 antibody  >4 publications with CRSP2 and MED15
 MED26 antibody  >4 publications with CRSP2 and MED26
 MED6 antibody  >3 publications with CRSP2 and MED6
 MED24 antibody  >3 publications with CRSP2 and MED24
 Products by Pathway  Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway antibodies  Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Generic Transcription Pathway antibodies  Generic Transcription Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 PPARA Activates Gene Expression Pathway antibodies  PPARA Activates Gene Expression Pathway Diagram
 Regulation Of Lipid Metabolism By Peroxisome Proliferator-activated Receptor Alpha (PPARalpha) Pathway antibodies  Regulation Of Lipid Metabolism By Peroxisome Proliferator-activated Receptor Alpha (PPARalpha) Pathway Diagram
 Thyroid Hormone Signaling Pathway antibodies  Thyroid Hormone Signaling Pathway Diagram
 Transcriptional Regulation Of White Adipocyte Differentiation Pathway antibodies  Transcriptional Regulation Of White Adipocyte Differentiation Pathway Diagram
Diseases associated with anti-CRSP2 antibodyOrgans/Tissues associated with anti-CRSP2 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >2 publications with CRSP2 and Inflammation
 Skin Diseases Antibodies  >1 publications with CRSP2 and Skin Diseases
 Breast Neoplasms Antibodies  >1 publications with CRSP2 and Breast Neoplasms
 Liver Diseases Antibodies  >1 publications with CRSP2 and Liver Diseases
 Organ/Tissue Name  Pubmed Publications
 Eye Antibodies  >2 publications with CRSP2 and Eye
 Thyroid Antibodies  >2 publications with CRSP2 and Thyroid
 Muscle Antibodies  >2 publications with CRSP2 and Muscle
 Blood Antibodies  >2 publications with CRSP2 and Blood
 Connective Tissue Antibodies  >1 publications with CRSP2 and Connective Tissue
 Kidney Antibodies  >1 publications with CRSP2 and Kidney
 Heart Antibodies  >1 publications with CRSP2 and Heart
 Testis Antibodies  >1 publications with CRSP2 and Testis
 Brain Antibodies  >1 publications with CRSP2 and Brain
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