NP_859066.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
Observed: 80 kDa Predicted: 74 kDa
NCBI Official Full Name
CREB-regulated transcription coactivator 2
NCBI Official Synonym Full Names
CREB regulated transcription coactivator 2
NCBI Protein Information
CREB-regulated transcription coactivator 2
UniProt Protein Name
CREB-regulated transcription coactivator 2
UniProt Synonym Protein Names
Transducer of regulated cAMP response element-binding protein 2; TORC-2; Transducer of CREB protein 2
UniProt Synonym Gene Names
NCBI Summary for CRTC2
This gene encodes a member of the transducers of regulated cAMP response element-binding protein activity family of transcription coactivators. These proteins promote the transcription of genes targeted by the cAMP response element-binding protein, and therefore play an important role in many cellular processes. Under basal conditions the encoded protein is phosphorylated by AMP-activated protein kinase or the salt-inducible kinases and is sequestered in the cytoplasm. Upon activation by elevated cAMP or calcium, the encoded protein translocates to the nucleus and increases target gene expression. Single nucleotide polymorphisms in this gene may increase the risk of type 2 diabetes. A pseudogene of this gene is located on the long arm of chromosome 5. [provided by RefSeq, Dec 2010]
UniProt Comments for CRTC2
Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR).
Research Articles on CRTC2
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Products associated with anti-CRTC2 antibody
Pathways associated with anti-CRTC2 antibody
Diseases associated with anti-CRTC2 antibody
Organs/Tissues associated with anti-CRTC2 antibody
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