NP_001036039.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
CREB-regulated transcription coactivator 3 isoform b
NCBI Official Synonym Full Names
CREB regulated transcription coactivator 3
NCBI Protein Information
CREB-regulated transcription coactivator 3
UniProt Protein Name
CREB-regulated transcription coactivator 3
UniProt Synonym Protein Names
Transducer of regulated cAMP response element-binding protein 3; TORC-3; Transducer of CREB protein 3
UniProt Synonym Gene Names
NCBI Summary for CRTC3
This gene is a member of the CREB regulated transcription coactivator gene family. This family regulates CREB-dependent gene transcription in a phosphorylation-independent manner and may be selective for cAMP-responsive genes. The protein encoded by this gene may induce mitochondrial biogenesis and attenuate catecholamine signaling in adipose tissue. A translocation event between this gene and Notch coactivator mastermind-like gene 2, which results in a fusion protein, has been reported in mucoepidermoid carcinomas. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]
UniProt Comments for CRTC3
Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR).
Research Articles on CRTC3
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Products associated with anti-CRTC3 antibody
Pathways associated with anti-CRTC3 antibody
Diseases associated with anti-CRTC3 antibody
Organs/Tissues associated with anti-CRTC3 antibody
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