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anti-CRY1 antibody :: Mouse anti-Human CRY1 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS246144
Unit / Price
0.05 mg  /  $555 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CRY1, Monoclonal Antibody

 Also Known As   

Mouse Monoclonal [clone 4H4-1C4] (IgG1,k) to Human CRY1

 Product Synonym Names    Anti-CRY1 Antibody (clone 4H4-1C4) IHC-plus; CRY1; Chryptochrome 1; Cryptochrome-1; Photolyase homolog 1; PHLL1; Human CRY1
 Product Gene Name   

anti-CRY1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    601933
 3D Structure    ModBase 3D Structure for Q16526
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 Clonality    Monoclonal
 Isotype    IgG1,k
 Clone Number    4H4-1C4
 Host    Mouse
 Species Reactivity    Human
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 Specificity    Human CRY1
 Purity/Purification    Protein A Purified
 Form/Format    PBS, pH 7.2
 Concentration    0.4 mg/ml (lot specific)
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 Target Species    Human
 Immunogen Description    CRY1 (AAH30519, 1 a.a. ~ 587 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
 Immunogen    CRY1 antibody was raised against cRY1 (AAH30519, 1 a.a. ~ 587 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
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 Preparation and Storage    Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles.
 Other Notes    Small volumes of anti-CRY1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-CRY1 antibody   

Immunohistochemistry (IHC - Paraffin), Immunofluorescence (IF), Western Blot (WB), ELISA (EIA)

 Application Notes for anti-CRY1 antibody    ELISA, IF (10 ug/ml), IHC-P (10 ug/ml), WB
Usage: Immunohistochemistry: Formalin-fixed paraffin-embedded sections. Sandwich ELISA: Recombinant protein. Western Blot: Cell lysate, Recombinant protein.
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 Immunohistochemistry (IHC) of anti-CRY1 antibody    Anti-CRY1 antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
anti-CRY1 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunofluorescence (IF) of anti-CRY1 antibody    Immunofluorescence of monoclonal antibody to CRY1 on HeLa cell. [antibody concentration 10 ug/ml]
anti-CRY1 antibody Immunofluorescence (IF) image
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 Western Blot (WB) of anti-CRY1 antibody    CRY1 monoclonal antibody, clone 4H4-1C4 Western blot of CRY1 expression in HeLa nuclear extract..
anti-CRY1 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for CRY1. It may not necessarily be applicable to this product.
 NCBI GI #    4758072
 NCBI GeneID    1407
 NCBI Accession #    NP_004066.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_004075.4 [Other Products]
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 UniProt Primary Accession #    Q16526 [Other Products]
 UniProt Related Accession #    Q16526 [Other Products]
 Molecular Weight    66,395 Da
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 NCBI Official Full Name    cryptochrome-1
 NCBI Official Synonym Full Names    cryptochrome circadian clock 1
 NCBI Official Symbol    CRY1 [Similar Products]
 NCBI Official Synonym Symbols   
PHLL1
[Similar Products]
 NCBI Protein Information    cryptochrome-1; cryptochrome 1 (photolyase-like)
 UniProt Protein Name    Cryptochrome-1
 Protein Family    Cryptochrome
 UniProt Gene Name    CRY1 [Similar Products]
 UniProt Synonym Gene Names    PHLL1 [Similar Products]
 UniProt Entry Name    CRY1_HUMAN
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 NCBI Summary for CRY1    This gene encodes a flavin adenine dinucleotide-binding protein that is a key component of the circadian core oscillator complex, which regulates the circadian clock. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene have been associated with altered sleep patterns. The encoded protein is widely conserved across plants and animals. Loss of the related gene in mouse results in a shortened circadian cycle in complete darkness. [provided by RefSeq, Jan 2014]
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 UniProt Comments for CRY1    CRY1: Blue light-dependent regulator of the circadian feedback loop. Inhibits CLOCK|NPAS2-ARNTL E box-mediated transcription. Acts, in conjunction with CRY2, in maintaining period length and circadian rhythmicity. Has no photolyase activity. Capable of translocating circadian clock core proteins such as PER proteins to the nucleus. May inhibit CLOCK|NPAS2-ARNTL transcriptional activity through stabilizing the unphosphorylated form of ARNTL. Component of the circadian core oscillator, which includes the CRY proteins, CLOCK or NPAS2, ARNTL or ARNTL2, CSNK1D and/or CSNK1E, TIMELESS, and the PER proteins. Interacts directly with TIMELESS and the PER proteins. Interacts directly with PER1 and PER2 C-terminal domains. Interaction with PER2 inhibits its ubiquitination and vice versa. Binds MAPK. Interacts with FBXL21. Interacts with FBXL3. Expression is regulated by light and circadian rhythms. Peak expression in the suprachiasma nucleus (SCN) and eye at the day/night transition (CT12). Levels decrease with ARNTL-CLOCK inhibition as part of the autoregulatory feedback loop. Belongs to the DNA photolyase class-1 family.

Protein type: DNA-binding; Transcription, coactivator/corepressor; Lyase

Chromosomal Location of Human Ortholog: 12q23-q24.1

Cellular Component: mitochondrion; nucleus

Molecular Function: ubiquitin binding; DNA (6-4) photolyase activity; histone deacetylase binding; nucleotide binding; protein kinase binding; transcription factor binding; phosphatase binding; protein binding; DNA binding; double-stranded DNA binding; deoxyribodipyrimidine photo-lyase activity; blue light photoreceptor activity; nuclear hormone receptor binding

Biological Process: circadian rhythm; response to glucagon stimulus; DNA damage induced protein phosphorylation; transcription, DNA-dependent; negative regulation of G-protein coupled receptor protein signaling pathway; negative regulation of transcription from RNA polymerase II promoter; regulation of circadian rhythm; glucose homeostasis; DNA repair; protein-chromophore linkage; entrainment of circadian clock by photoperiod; response to insulin stimulus; gluconeogenesis; blue light signaling pathway; sequestering of lipid; negative regulation of protein ubiquitination; negative regulation of circadian rhythm; circadian regulation of gene expression; negative regulation of transcription, DNA-dependent
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 Research Articles on CRY1    1. findings show the polymorphisms of Cry1 rs2287161 and Tef rs738499 are associated to major depressive disorder in the Chinese population
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CRY1 antibodyPathways associated with anti-CRY1 antibody
 Reference Product  PubMed Publications
 CLOCK antibody  >467 publications with CRY1 and CLOCK
 CRY2 antibody  >376 publications with CRY1 and CRY2
 PER2 antibody  >261 publications with CRY1 and PER2
 PER1 antibody  >245 publications with CRY1 and PER1
 ARNTL antibody  >132 publications with CRY1 and ARNTL
 PER3 antibody  >78 publications with CRY1 and PER3
 NPAS2 antibody  >40 publications with CRY1 and NPAS2
 FBXL3 antibody  >13 publications with CRY1 and FBXL3
 CSNK1E antibody  >8 publications with CRY1 and CSNK1E
 Products by Pathway  Pathway Diagram
 BMAL1:CLOCK,NPAS2 Activates Circadian Gene Expression Pathway antibodies  BMAL1:CLOCK,NPAS2 Activates Circadian Gene Expression Pathway Diagram
 Circadian Clock Pathway antibodies  Circadian Clock Pathway Diagram
 Circadian Rhythm Pathway antibodies  Circadian Rhythm Pathway Diagram
 Circadian Rhythm Pathway antibodies  Circadian Rhythm Pathway Diagram
 Diurnally Regulated Genes With Circadian Orthologs Pathway antibodies  Diurnally Regulated Genes With Circadian Orthologs Pathway Diagram
Diseases associated with anti-CRY1 antibodyOrgans/Tissues associated with anti-CRY1 antibody
 Disease Name  Pubmed Publications
 Mental Disorders Antibodies  >24 publications with CRY1 and Mental Disorders
 Disease Models, Animal Antibodies  >16 publications with CRY1 and Disease Models, Animal
 Cardiovascular Diseases Antibodies  >14 publications with CRY1 and Cardiovascular Diseases
 Brain Diseases Antibodies  >13 publications with CRY1 and Brain Diseases
 Inflammation Antibodies  >11 publications with CRY1 and Inflammation
 Necrosis Antibodies  >11 publications with CRY1 and Necrosis
 Breast Neoplasms Antibodies  >10 publications with CRY1 and Breast Neoplasms
 Hypertension Antibodies  >7 publications with CRY1 and Hypertension
 Fatty Liver Antibodies  >6 publications with CRY1 and Fatty Liver
 Immune System Diseases Antibodies  >6 publications with CRY1 and Immune System Diseases
 Organ/Tissue Name  Pubmed Publications
 Eye Antibodies  >199 publications with CRY1 and Eye
 Brain Antibodies  >178 publications with CRY1 and Brain
 Liver Antibodies  >96 publications with CRY1 and Liver
 Blood Antibodies  >70 publications with CRY1 and Blood
 Muscle Antibodies  >32 publications with CRY1 and Muscle
 Heart Antibodies  >28 publications with CRY1 and Heart
 Kidney Antibodies  >20 publications with CRY1 and Kidney
 Connective Tissue Antibodies  >16 publications with CRY1 and Connective Tissue
 Intestine Antibodies  >14 publications with CRY1 and Intestine
 Embryonic Tissue Antibodies  >12 publications with CRY1 and Embryonic Tissue
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