NP_000487.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
beta-crystallin B2
NCBI Official Synonym Full Names
crystallin beta B2
NCBI Official Synonym Symbols
CCA2; CRYB2; CRYB2A; CTRCT3; D22S665 [Similar Products]
NCBI Protein Information
beta-crystallin B2
UniProt Protein Name
Beta-crystallin B2
UniProt Synonym Protein Names
Beta-B2 crystallin; Beta-crystallin Bp
UniProt Synonym Gene Names
NCBI Summary for CRYBB2
Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Beta-crystallins, the most heterogeneous, differ by the presence of the C-terminal extension (present in the basic group, none in the acidic group). Beta-crystallins form aggregates of different sizes and are able to self-associate to form dimers or to form heterodimers with other beta-crystallins. This gene, a beta basic group member, is part of a gene cluster with beta-A4, beta-B1, and beta-B3. A chain-terminating mutation was found to cause type 2 cerulean cataracts. [provided by RefSeq, Jul 2008]
UniProt Comments for CRYBB2
Crystallins are the dominant structural components of the vertebrate eye lens.
Research Articles on CRYBB2
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Products associated with anti-CRYBB2 antibody
Pathways associated with anti-CRYBB2 antibody
Diseases associated with anti-CRYBB2 antibody
Organs/Tissues associated with anti-CRYBB2 antibody
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