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anti-CSE1L antibody :: Mouse anti-Human CSE1L Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS120449
Unit / Price
0.1 mg  /  $345 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CSE1L, Monoclonal Antibody

 Also Known As   

Mouse monoclonal antibody Anti-Human CSE1L

 Product Synonym Names    Homo sapiens CSE1 chromosome segregation 1-like (yeast) (CSE1L), mRNA.; CAS; CSE1; XPO2; MGC117283; MGC130036; MGC130037
 Product Gene Name   

anti-CSE1L antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    DEEFQRYLPR FVTAIWNLLV TTGQEVKYDL LVSNAIQFLA SVCERPHYKN LFEDQNTLTS ICEKVIVPNM EFRAADEEAF EDNSEEYIRR DLEGSDIDTR RRAA
 OMIM    601342
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 Clonality    Monoclonal
 Isotype    IgG2a
 Clone Number    2218C5a
 Host    Mouse
 Species Reactivity    Human
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 Concentration    100 ug/ml (1.0 ml) (lot specific)
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 Preparation    This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.
 Sterility    Filtered through a 0.22 um membrane.
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 Other Notes    Small volumes of anti-CSE1L antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CSE1L antibody

   Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importinalpha must then be returned to the cytoplasm, leaving the NLS protein behind. The protein encoded by this gene binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. In addition, the encoded protein may play a role both in apoptosis and in cell proliferation.[NCBI Entrez Gene Summary]
 Applications Tested/Suitable for anti-CSE1L antibody   

Dot Blot (DB), Immunocytochemistry (ICC), Western Blot (WB)

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 Quality Control of anti-CSE1L antibody    Western blot analysis of immunized recombinant protein, using anti-CSE1L monoclonal antibody.
anti-CSE1L antibody Quality Control image
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 Quality Control #2 of anti-CSE1L antibody    Arrow indicates the region of immunized recombinant protein carrying 50-200 amino acids.
anti-CSE1L antibody Quality Control #2 image
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 Western Blot (WB) of anti-CSE1L antibody    Detection of CSE1L by Western blot.

Samples: Whole cell lysate from human HEK293 (H, 25 ug), mouse NIH3T3 (M, 25 ug) and rat F2408 (R, 25 ug) cells. [Lot No. 2218C5a-1]

Predicted molecular weight: 110 kDa
anti-CSE1L antibody Western Blot (WB) (WB) image
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 Immunocytochemistry (ICC) of anti-CSE1L antibody    Immunostaining analysis in HeLa cells. HeLa cells were fixed with 4% paraformaldehyde and permeabilized with 0.1% Triton X-100 in PBS. The cells were immunostained with anti-CSE1L mAb. [Lot No.2218C5a-1]
anti-CSE1L antibody Immunocytochemistry (ICC) (ICC) image
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NCBI/Uniprot data below describe general gene information for CSE1L. It may not necessarily be applicable to this product.
 NCBI GI #    371502110
 NCBI GeneID    1434
 NCBI Accession #    NP_001307.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_001316 [Other Products]
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 UniProt Secondary Accession #    O75432; Q32M40; Q9H5B7; Q9NTS0; Q9UP98; Q9UP99; Q9UPA0; A3RLL6; B2R5T4; E1P5Y0; F8W904 [Other Products]
 UniProt Related Accession #    P55060 [Other Products]
 Molecular Weight    103,879 Da
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 NCBI Official Full Name    Homo sapiens CSE1 chromosome segregation 1-like (yeast) (CSE1L), transcript variant 1, mRNA
 NCBI Official Synonym Full Names    CSE1 chromosome segregation 1-like (yeast)
 NCBI Official Symbol    CSE1L [Similar Products]
 NCBI Official Synonym Symbols   
CAS; CSE1; XPO2
[Similar Products]
 NCBI Protein Information    exportin-2; cellular apoptosis susceptibility protein; chromosome segregation 1-like protein; exp2; importin-alpha re-exporter
 UniProt Protein Name    Exportin-2
 UniProt Synonym Protein Names   
Cellular apoptosis susceptibility protein; Chromosome segregation 1-like protein; Importin-alpha re-exporter
 UniProt Gene Name    CSE1L [Similar Products]
 UniProt Entry Name    XPO2_HUMAN
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 NCBI Summary for CSE1L    Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importin-alpha must then be returned to the cytoplasm, leaving the NLS protein behind. The protein encoded by this gene binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. In addition, the encoded protein may play a role both in apoptosis and in cell proliferation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]
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 UniProt Comments for CSE1L    Exportin-2: Export receptor for importin-alpha. Mediates importin- alpha re-export from the nucleus to the cytoplasm after import substrates (cargos) have been released into the nucleoplasm. In the nucleus binds cooperatively to importin-alpha and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the importin-alpha from the export receptor. CSE1L/XPO2 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Belongs to the XPO2/CSE1 family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Nuclear import; Nuclear export; Karyopherin

Chromosomal Location of Human Ortholog: 20q13

Cellular Component: nucleoplasm; membrane; cytoplasm; nucleus

Molecular Function: importin-alpha export receptor activity; protein binding; Ran GTPase binding

Biological Process: cell proliferation; apoptosis; protein export from nucleus
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 Research Articles on CSE1L    1. These results indicate that CSE1L is associated with viability and apoptosis, cellular adhesion and invasion, thus implicating CSE1L in the progression of colorectal cancer.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-CSE1L antibodyDiseases associated with anti-CSE1L antibody
 Products by Pathway  Pathway Diagram
 Direct P53 Effectors Pathway antibodies  Direct P53 Effectors Pathway Diagram
 P53 Pathway antibodies  P53 Pathway Diagram
 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >14 publications with CSE1L and Carcinoma
 Neoplasm Metastasis Antibodies  >9 publications with CSE1L and Neoplasm Metastasis
 Breast Neoplasms Antibodies  >6 publications with CSE1L and Breast Neoplasms
 Neoplasms, Experimental Antibodies  >5 publications with CSE1L and Neoplasms, Experimental
 Liver Diseases Antibodies  >4 publications with CSE1L and Liver Diseases
 Head and Neck Neoplasms Antibodies  >4 publications with CSE1L and Head and Neck Neoplasms
 Nervous System Diseases Antibodies  >4 publications with CSE1L and Nervous System Diseases
 Liver Neoplasms Antibodies  >3 publications with CSE1L and Liver Neoplasms
 Carcinoma, Hepatocellular Antibodies  >3 publications with CSE1L and Carcinoma, Hepatocellular
 Inflammation Antibodies  >2 publications with CSE1L and Inflammation
Organs/Tissues associated with anti-CSE1L antibody
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >5 publications with CSE1L and Liver
 Lymph Node Antibodies  >5 publications with CSE1L and Lymph Node
 Blood Antibodies  >5 publications with CSE1L and Blood
 Lymph Antibodies  >5 publications with CSE1L and Lymph
 Brain Antibodies  >4 publications with CSE1L and Brain
 Intestine Antibodies  >3 publications with CSE1L and Intestine
 Bladder Antibodies  >3 publications with CSE1L and Bladder
 Kidney Antibodies  >2 publications with CSE1L and Kidney
 Skin Antibodies  >2 publications with CSE1L and Skin
 Vascular Antibodies  >2 publications with CSE1L and Vascular
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