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anti-CTLA-4 antibody :: Hamster CTLA-4 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS140017 anti-CTLA-4 antibody
Unit / Price
0.5 mg  /  $305 +1 FREE 8GB USB
1 mg  /  $455 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CTLA-4, Monoclonal Antibody

 Also Known As   

Hamster Anti Mouse CTLA-4 (CD152)

 Product Synonym Names    CTLA 4 Antibody; CTLA-4 (CD152), Hamster Anti-Mouse; GSE; CD152; IDDM12; CELIAC3; CTLA-4
 Product Gene Name   

anti-CTLA-4 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    109100
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 Clonality    Monoclonal
 Isotype    IgG
 Clone Number    RYNmCTLA-4
 Host    Hamster
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 Purity/Purification    Ion exchange column.
 Concentration    1mg/ml in PBS (after reconstitution). (lot specific)
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 Reconstitution    Reconstitute with of H20. Mix gently, wash the sides of the vial and wait 30-60 seconds before use.
 Immunogen    mixture of mouse activated T cells.
 Antibody Properties    Blocking and staining antibody. For staining, use for blocking CTLA-4 function should be determined by the investigator.
 Available Conjugates    This antibody is only available as purified antibody.
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 Preparation and Storage    Lyophilized: store at 4 degree C. After reconstitution, if not intended for use within a month, aliquot and store at -20 degree C.
 Other Notes    Small volumes of anti-CTLA-4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-CTLA-4 antibody

   Introduction: CTLA-4 is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases.
 Product Categories/Family for anti-CTLA-4 antibody    MONOCLONAL ANTIBODIES, ANTI-MOUSE CYTOKINE; Monoclonal Antibodies; Anti Mouse Cytokine
NCBI/Uniprot data below describe general gene information for CTLA-4. It may not necessarily be applicable to this product.
 NCBI GI #    83700231
 NCBI GeneID    1493
 NCBI Accession #    NP_001032720.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001037631.2 [Other Products]
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 UniProt Secondary Accession #    O95653; Q0PP65; Q52MC1; Q53TD5; Q5S005; Q8WXJ1; Q96P43; Q9UKN9; A0N1S0; E9PDH0 [Other Products]
 UniProt Related Accession #    P16410 [Other Products]
 Molecular Weight    19,145 Da
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 NCBI Official Full Name    cytotoxic T-lymphocyte protein 4 isoform CTLA-4delTM
 NCBI Official Synonym Full Names    cytotoxic T-lymphocyte-associated protein 4
 NCBI Official Symbol    CTLA4 [Similar Products]
 NCBI Official Synonym Symbols   
CD; GSE; GRD4; ALPS5; CD152; CTLA-4; IDDM12; CELIAC3
[Similar Products]
 NCBI Protein Information    cytotoxic T-lymphocyte protein 4; CD152 isoform; celiac disease 3; cytotoxic T lymphocyte associated antigen 4 short spliced form; cytotoxic T-lymphocyte-associated serine esterase-4; insulin-dependent diabetes mellitus 12; ligand and transmembrane spliced cytotoxic T lymphocyte associated antigen 4
 UniProt Protein Name    Cytotoxic T-lymphocyte protein 4
 UniProt Synonym Protein Names   
Cytotoxic T-lymphocyte-associated antigen 4; CTLA-4; CD_antigen: CD152
 UniProt Gene Name    CTLA4 [Similar Products]
 UniProt Synonym Gene Names    CD152; CTLA-4 [Similar Products]
 UniProt Entry Name    CTLA4_HUMAN
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 NCBI Summary for CTLA-4    This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases. [provided by RefSeq, Jul 2008]
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 UniProt Comments for CTLA-4    CTLA-4: Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28. Genetic variation in CTLA4 influences susceptibility to systemic lupus erythematosus (SLE). SLE is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. SLE is thought to represent a failure of the regulatory mechanisms of the autoimmune system. Genetic variations in CTLA4 may influence susceptibility to Graves disease, an autoimmune disorder associated with overactivity of the thyroid gland and hyperthyroidism. Genetic variation in CTLA4 is the cause of susceptibility to diabetes mellitus insulin-dependent type 12 (IDDM12). A multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical fetaures are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels. Genetic variation in CTLA4 is the cause of susceptibility to celiac disease type 3 (CELIAC3). It is a multifactorial disorder of the small intestine that is influenced by both environmental and genetic factors. It is characterized by malabsorption resulting from inflammatory injury to the mucosa of the small intestine after the ingestion of wheat gluten or related rye and barley proteins. In its classic form, celiac disease is characterized in children by malabsorption and failure to thrive. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Immunoglobulin superfamily

Chromosomal Location of Human Ortholog: 2q33

Cellular Component: Golgi apparatus; integral to plasma membrane; perinuclear region of cytoplasm; plasma membrane; clathrin-coated endocytic vesicle; external side of plasma membrane

Molecular Function: protein binding

Biological Process: B cell receptor signaling pathway; negative regulation of T cell proliferation; negative regulation of regulatory T cell differentiation; positive regulation of apoptosis; T cell costimulation; negative regulation of immune response; immune response; negative regulation of B cell proliferation; response to DNA damage stimulus

Disease: Autoimmune Lymphoproliferative Syndrome, Type V; Celiac Disease, Susceptibility To, 3; Diabetes Mellitus, Insulin-dependent, 12; Systemic Lupus Erythematosus; Hashimoto Thyroiditis
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 Research Articles on CTLA-4    1. No significant association between CTLA-4 +49A/G polymorphism and susceptibility to autoimmune hepatitis was found.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CTLA-4 antibodyPathways associated with anti-CTLA-4 antibody
 Reference Product  PubMed Publications
 CD80 antibody  >1018 publications with CTLA-4 and CD80
 CD86 antibody  >655 publications with CTLA-4 and CD86
 FOXP3 antibody  >624 publications with CTLA-4 and FOXP3
 LCK antibody  >18 publications with CTLA-4 and LCK
 PTPN11 antibody  >13 publications with CTLA-4 and PTPN11
 CD276 antibody  >10 publications with CTLA-4 and CD276
 FYN antibody  >7 publications with CTLA-4 and FYN
 LYN antibody  >5 publications with CTLA-4 and LYN
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Autoimmune Thyroid Disease Pathway antibodies  Autoimmune Thyroid Disease Pathway Diagram
 Autoimmune Thyroid Disease Pathway antibodies  Autoimmune Thyroid Disease Pathway Diagram
 CTLA4 Inhibitory Signaling Pathway antibodies  CTLA4 Inhibitory Signaling Pathway Diagram
 Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway antibodies  Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Costimulation By The CD28 Family Pathway antibodies  Costimulation By The CD28 Family Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Rheumatoid Arthritis Pathway antibodies  Rheumatoid Arthritis Pathway Diagram
Diseases associated with anti-CTLA-4 antibodyOrgans/Tissues associated with anti-CTLA-4 antibody
 Disease Name  Pubmed Publications
 Immune System Diseases Antibodies  >1642 publications with CTLA-4 and Immune System Diseases
 Melanoma Antibodies  >547 publications with CTLA-4 and Melanoma
 Inflammation Antibodies  >380 publications with CTLA-4 and Inflammation
 Necrosis Antibodies  >374 publications with CTLA-4 and Necrosis
 Arthritis, Rheumatoid Antibodies  >228 publications with CTLA-4 and Arthritis, Rheumatoid
 Carcinoma Antibodies  >202 publications with CTLA-4 and Carcinoma
 Graves Disease Antibodies  >179 publications with CTLA-4 and Graves Disease
 Neoplasms, Experimental Antibodies  >159 publications with CTLA-4 and Neoplasms, Experimental
 Liver Diseases Antibodies  >158 publications with CTLA-4 and Liver Diseases
 Neoplasm Metastasis Antibodies  >92 publications with CTLA-4 and Neoplasm Metastasis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >3193 publications with CTLA-4 and Blood
 Lymph Node Antibodies  >248 publications with CTLA-4 and Lymph Node
 Lung Antibodies  >220 publications with CTLA-4 and Lung
 Kidney Antibodies  >209 publications with CTLA-4 and Kidney
 Prostate Antibodies  >87 publications with CTLA-4 and Prostate
 Mammary Gland Antibodies  >1 publications with CTLA-4 and Mammary Gland
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