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anti-CXCL11 antibody :: Mouse anti-Human CXCL11 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS690431 anti-CXCL11 antibody
Unit / Price
0.1 mg  /  $505 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CXCL11, Monoclonal Antibody

★Popular Item★
 Also Known As   

Mouse Anti-Human CXCL11

 Product Synonym Names    CXCL11; IP9; H174; IP-9; b-R1; I-TAC; SCYB11; SCYB9B
 Product Gene Name   

anti-CXCL11 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 4; NC_000004.12 (76033682..76036197, complement). Location: 4q21.2
 OMIM    604852
 3D Structure    ModBase 3D Structure for O14625
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 Clonality    Monoclonal
 Isotype    IgG2
 Clone Number    9N26
 Host    Mouse
 Species Reactivity    Human
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 Purity/Purification    Protein G chromatography
 Form/Format    Lyophilized
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 Antibody Generation    This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse) immunized with human recombinant CXCL11 (also called I-TAC).
 Antigen    human recombinant CXCL11
 Reconstitution buffer    PBS (sterile)
 Reconstitution    Reconstitute the antibody with 200 ul sterile PBS and the final concentration is 500 ug/ml.
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 Preparation and Storage    Lyophilized samples are stable for 2 years from date of receipt when stored at -70 degree C. Reconstituted antibody can be aliquoted and stored frozen at < -20 degree C for at least for six months without detectable loss of activity.
Shipping: Ships with cold packs
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-CXCL11 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CXCL11 antibody

   NAP-2 or CXCL7 is a CXC chemokine that can signal through the CXCR1 and CXCR2 receptors. It is produced in leukocytes by enzymatic processing of a precursor called platelet basic protein (PBP). NAP-2 chemoattracts and activates neutrophils. Recombinant human NAP-2 protein is a 7.6 kDa protein containing 70 amino acid residues including the four highly conserved cysteine residues present in CXC chemokines, and also including the ELR motif common to CXC chemokines that bind to CXCR1 and CXCR2
 Applications Tested/Suitable for anti-CXCL11 antibody   

Western Blot (WB), Neutr

 Application Notes for anti-CXCL11 antibody    WB: 1:500 - 1000
Neutralization: of CXCL11 bioactivity
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NCBI/Uniprot data below describe general gene information for CXCL11. It may not necessarily be applicable to this product.
 NCBI GI #    4885589
 NCBI GeneID    6373
 NCBI Accession #    NP_005400.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_005409.4 [Other Products]
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 UniProt Primary Accession #    O14625 [Other Products]
 UniProt Secondary Accession #    Q53YA3; Q92840 [Other Products]
 UniProt Related Accession #    O14625 [Other Products]
 Molecular Weight    10,365 Da
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 NCBI Official Full Name    C-X-C motif chemokine 11
 NCBI Official Synonym Full Names    chemokine (C-X-C motif) ligand 11
 NCBI Official Symbol    CXCL11 [Similar Products]
 NCBI Official Synonym Symbols   
IP9; H174; IP-9; b-R1; I-TAC; SCYB11; SCYB9B
[Similar Products]
 NCBI Protein Information    C-X-C motif chemokine 11; beta-R1; small inducible cytokine B11; small-inducible cytokine B11; interferon gamma-inducible protein 9; interferon-inducible T-cell alpha chemoattractant; small inducible cytokine subfamily B (Cys-X-Cys), member 11; small inducible cytokine subfamily B (Cys-X-Cys), member 9B
 UniProt Protein Name    C-X-C motif chemokine 11
 UniProt Synonym Protein Names   
Beta-R1; H174; Interferon gamma-inducible protein 9; IP-9; Interferon-inducible T-cell alpha chemoattractant; I-TAC; Small-inducible cytokine B11
 Protein Family    C-X-C motif chemokine
 UniProt Gene Name    CXCL11 [Similar Products]
 UniProt Synonym Gene Names    ITAC; SCYB11; SCYB9B; IP-9; I-TAC [Similar Products]
 UniProt Entry Name    CXL11_HUMAN
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 NCBI Summary for CXCL11    Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC. This gene is a CXC member of the chemokine superfamily. Its encoded protein induces a chemotactic response in activated T-cells and is the dominant ligand for CXC receptor-3. The gene encoding this protein contains 4 exons and at least three polyadenylation signals which might reflect cell-specific regulation of expression. IFN-gamma is a potent inducer of transcription of this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for CXCL11    Function: Chemotactic for interleukin-activated T-cells but not unstimulated T-cells, neutrophils or monocytes. Induces calcium release in activated T-cells. Binds to CXCR3. May play an important role in CNS diseases which involve T-cell recruitment. May play a role in skin immune responses.

Subcellular location: Secreted.

Tissue specificity: High levels in peripheral blood leukocytes, pancreas and liver astrocytes. Moderate levels in thymus, spleen and lung. Low levels in placenta, prostate and small intestine. Also found in epidermal basal layer keratinocytes in skin disorders.

Induction: By IFNG/IFN-gamma and IFNB1/IFN-beta. Induction by IFNG/IFN-gamma is enhanced by TNF in monocytes, dermal fibroblasts and endothelial cells, and by IL1/interleukin-1 in astrocytes.

Sequence similarities: Belongs to the intercrine alpha (chemokine CxC) family.

Mass spectrometry: Molecular mass is 8303 Da from positions 22 - 94. Determined by MALDI. Ref.4

Sequence caution: The sequence AAB17374.1 differs from that shown. Reason: Erroneous initiation.
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 Research Articles on CXCL11    1. CXCL11 was mildlylavage fluid during diffuse alveolar damage, but not during acute rejection or lymphocytic bronchiolitis. Elevated CXCL11 was associated with increased risk of chronic allograft dysfunction.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CXCL11 antibodyPathways associated with anti-CXCL11 antibody
 Reference Product  PubMed Publications
 CXCL10 antibody  >421 publications with CXCL11 and CXCL10
 CXCL9 antibody  >330 publications with CXCL11 and CXCL9
 CXCR3 antibody  >281 publications with CXCL11 and CXCR3
 CCL5 antibody  >83 publications with CXCL11 and CCL5
 CCR5 antibody  >36 publications with CXCL11 and CCR5
 CXCR7 antibody  >35 publications with CXCL11 and CXCR7
 CXCL13 antibody  >14 publications with CXCL11 and CXCL13
 CCR3 antibody  >10 publications with CXCL11 and CCR3
 CXCL6 antibody  >9 publications with CXCL11 and CXCL6
 PF4 antibody  >5 publications with CXCL11 and PF4
 Products by Pathway  Pathway Diagram
 CXCR3-mediated Signaling Events Pathway antibodies  CXCR3-mediated Signaling Events Pathway Diagram
 Chemokine Receptors Bind Chemokines Pathway antibodies  Chemokine Receptors Bind Chemokines Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
Diseases associated with anti-CXCL11 antibodyOrgans/Tissues associated with anti-CXCL11 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >167 publications with CXCL11 and Inflammation
 Neoplasms Antibodies  >91 publications with CXCL11 and Neoplasms
 Necrosis Antibodies  >67 publications with CXCL11 and Necrosis
 Lung Diseases Antibodies  >53 publications with CXCL11 and Lung Diseases
 Disease Models, Animal Antibodies  >51 publications with CXCL11 and Disease Models, Animal
 Liver Diseases Antibodies  >29 publications with CXCL11 and Liver Diseases
 Cardiovascular Diseases Antibodies  >28 publications with CXCL11 and Cardiovascular Diseases
 Fibrosis Antibodies  >22 publications with CXCL11 and Fibrosis
 Kidney Diseases Antibodies  >20 publications with CXCL11 and Kidney Diseases
 Adenocarcinoma Antibodies  >17 publications with CXCL11 and Adenocarcinoma
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >78 publications with CXCL11 and Lung
 Vascular Antibodies  >70 publications with CXCL11 and Vascular
 Skin Antibodies  >49 publications with CXCL11 and Skin
 Liver Antibodies  >37 publications with CXCL11 and Liver
 Muscle Antibodies  >26 publications with CXCL11 and Muscle
 Intestine Antibodies  >24 publications with CXCL11 and Intestine
 Bone Marrow Antibodies  >22 publications with CXCL11 and Bone Marrow
 Mouth Antibodies  >13 publications with CXCL11 and Mouth
 Uterus Antibodies  >7 publications with CXCL11 and Uterus
 Connective Tissue Antibodies  >4 publications with CXCL11 and Connective Tissue
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