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anti-CXCR2 antibody :: Mouse anti-Human CXCR2 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS245237
Immunohistochemistry (IHC)
Unit / Price
0.05 mg  /  $495 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CXCR2, Monoclonal Antibody

 Also Known As   

Mouse Monoclonal (IgG1) to Human CXCR2

 Product Synonym Names    Anti-CXCR2 Antibody IHC-plus; CXCR2; CDw128b; CD182 antigen; CMKAR2; CXCR-2; CD182; CXC-R2; IL-8R B; Il-8 receptor b; IL-8 receptor type 2; Il-8rb; IL8R2; IL8RB; Interleukin-8 receptor type B; GRO/MGSA receptor; Interleukin 8 receptor beta; Interleukin 8 receptor; beta; Human CXCR2
 Product Gene Name   

anti-CXCR2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    146928
 3D Structure    ModBase 3D Structure for P25025
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 Clonality    Monoclonal
 Isotype    IgG1
 Host    Mouse
 Species Reactivity    Human
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 Specificity    Recognizes human IL-8 receptor, type B.
 Purity/Purification    Protein G Purified
 Form/Format    PBS.
 Concentration    1 mg/ml (lot specific)
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 Target Species    Human
 Immunogen Description    L1.2 cells expressing human IL-8 (interleukin-8) receptor, type B.
 Immunogen Type    Cells
 Immunogen    CXCR2 antibody was raised against l1.2 cells expressing human IL-8 (interleukin-8) receptor, type B.
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 Preparation and Storage    Short term +4 degree C (no longer than one week); Long term -20 degree C; Aliquot to avoid freeze/thaw cycles.
 Other Notes    Small volumes of anti-CXCR2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-CXCR2 antibody

   The IL8RB is a Chemokine Receptor also known as type 1 interleukin-8 receptor. There are three interleukin-8 receptors on chromosome 2: IL8RA (type 2), IL8RB (type 1), and a pseudogene. Results from mouse knock-out studies suggest that IL8RB may inhibit the expansion and development of neutrophils and B cells (Cacalano et al., 1994). IL8RB is a high-affinity receptor for IL8, and for GROalpha, beta, and gamma (Ahuja and Murphy, 1996).
 Product Categories/Family for anti-CXCR2 antibody    Family: GPCR
Subfamily: Chemokine
 Applications Tested/Suitable for anti-CXCR2 antibody   

Immunohistochemistry (IHC - Paraffin), Flow Cytometry (FC/FACS)

 Application Notes for anti-CXCR2 antibody    Flo, IHC-P (2.5 - 5 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...
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 Immunohistochemistry (IHC) of anti-CXCR2 antibody    Anti-CXCR2 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
anti-CXCR2 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for CXCR2. It may not necessarily be applicable to this product.
 NCBI GI #    4504683
 NCBI GeneID    3579
 NCBI Accession #    NP_001548.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001557.3 [Other Products]
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 UniProt Primary Accession #    P25025 [Other Products]
 UniProt Secondary Accession #    Q8IUZ1; Q9P2T6; Q9P2T7 [Other Products]
 UniProt Related Accession #    P25025; AAA15417; AAB24742 [Other Products]
 Molecular Weight    40,759 Da
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 NCBI Official Full Name    C-X-C chemokine receptor type 2
 NCBI Official Synonym Full Names    chemokine (C-X-C motif) receptor 2
 NCBI Official Symbol    CXCR2 [Similar Products]
 NCBI Official Synonym Symbols   
CD182; IL8R2; IL8RA; IL8RB; CMKAR2; CDw128b
[Similar Products]
 NCBI Protein Information    C-X-C chemokine receptor type 2; CXC-R2; CXCR-2; IL-8R B; GRO/MGSA receptor; IL-8 receptor type 2; interleukin 8 receptor B; chemokine (CXC) receptor 2; interleukin 8 receptor, beta; interleukin 8 receptor type 2; interleukin-8 receptor type B; CXCR2 gene for IL8 receptor type B; high affinity interleukin-8 receptor B
 UniProt Protein Name    C-X-C chemokine receptor type 2
 UniProt Synonym Protein Names   
CDw128b; GRO/MGSA receptor; High affinity interleukin-8 receptor B; IL-8R B; IL-8 receptor type 2; CD_antigen: CD182
 Protein Family    C-X-C chemokine receptor
 UniProt Gene Name    CXCR2 [Similar Products]
 UniProt Synonym Gene Names    IL8RB; CXC-R2; CXCR-2; IL-8R B [Similar Products]
 UniProt Entry Name    CXCR2_HUMAN
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 NCBI Summary for CXCR2    The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. Alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2009]
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 UniProt Comments for CXCR2    IL-8R B: Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2. Belongs to the G-protein coupled receptor 1 family.

Protein type: Receptor, cytokine; GPCR, family 1; Membrane protein, integral; Receptor, GPCR; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 2q35

Cellular Component: cell surface; mast cell granule; membrane; integral to plasma membrane; plasma membrane; intracellular

Molecular Function: signal transducer activity; protein binding; interleukin-8 receptor activity; interleukin-8 binding; C-X-C chemokine receptor activity

Biological Process: neutrophil chemotaxis; neutrophil activation; signal transduction; chemotaxis; positive regulation of vascular permeability; negative regulation of neutrophil apoptosis; elevation of cytosolic calcium ion concentration; positive regulation of angiogenesis; cell surface receptor linked signal transduction; receptor internalization; midbrain development; positive regulation of cell proliferation; dendritic cell chemotaxis; cellular defense response; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); inflammatory response; acute inflammatory response to antigenic stimulus
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 Research Articles on CXCR2    1. CXCR1 and CXCR2 (rs4674258C/T, rs1008563C/T, rs6723449T/C) were analyzed for association with IL8 levels and with myocardial infarct risk.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CXCR2 antibodyPathways associated with anti-CXCR2 antibody
 Reference Product  PubMed Publications
 CXCR1 antibody  >505 publications with CXCR2 and CXCR1
 CXCL1 antibody  >325 publications with CXCR2 and CXCL1
 CXCL2 antibody  >151 publications with CXCR2 and CXCL2
 CXCL5 antibody  >87 publications with CXCR2 and CXCL5
 IL8 antibody  >73 publications with CXCR2 and IL8
 CXCL6 antibody  >24 publications with CXCR2 and CXCL6
 CXCL3 antibody  >12 publications with CXCR2 and CXCL3
 PPBP antibody  >11 publications with CXCR2 and PPBP
 VASP antibody  >1 publications with CXCR2 and VASP
 Products by Pathway  Pathway Diagram
 Chemokine Receptors Bind Chemokines Pathway antibodies  Chemokine Receptors Bind Chemokines Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies  Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
Diseases associated with anti-CXCR2 antibodyOrgans/Tissues associated with anti-CXCR2 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >501 publications with CXCR2 and Inflammation
 Lung Diseases Antibodies  >186 publications with CXCR2 and Lung Diseases
 Disease Models, Animal Antibodies  >160 publications with CXCR2 and Disease Models, Animal
 Necrosis Antibodies  >127 publications with CXCR2 and Necrosis
 Sepsis Antibodies  >60 publications with CXCR2 and Sepsis
 Asthma Antibodies  >48 publications with CXCR2 and Asthma
 Liver Diseases Antibodies  >39 publications with CXCR2 and Liver Diseases
 Adenocarcinoma Antibodies  >38 publications with CXCR2 and Adenocarcinoma
 Fibrosis Antibodies  >37 publications with CXCR2 and Fibrosis
 Neoplasms, Experimental Antibodies  >35 publications with CXCR2 and Neoplasms, Experimental
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >763 publications with CXCR2 and Blood
 Lung Antibodies  >238 publications with CXCR2 and Lung
 Bone Antibodies  >128 publications with CXCR2 and Bone
 Brain Antibodies  >94 publications with CXCR2 and Brain
 Intestine Antibodies  >42 publications with CXCR2 and Intestine
 Heart Antibodies  >38 publications with CXCR2 and Heart
 Spleen Antibodies  >31 publications with CXCR2 and Spleen
 Prostate Antibodies  >26 publications with CXCR2 and Prostate
 Connective Tissue Antibodies  >24 publications with CXCR2 and Connective Tissue
 Trachea Antibodies  >6 publications with CXCR2 and Trachea
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