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anti-KRT17 antibody :: Mouse anti-Bovine, Pig CYTOKERATIN 7/17 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS214467 anti-KRT17 antibody
Unit / Price
0.1 mg  /  $415 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CYTOKERATIN 7/17 (KRT17), Monoclonal Antibody

 Also Known As   

MOUSE ANTI HUMAN CYTOKERATIN 7/17

 Product Gene Name   

anti-KRT17 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    148069
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    C-46
 Host    Mouse
 Species Reactivity    Bovine, Pig
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 Specificity    This item specifically recognises a unique epitope shared by the intermediate filament keratins, cytokeratin 7 and cytokeratin 17, a 54kDa type II basic cytokeratin, and 46kDa type I acidic cytokeratin respectively. Cytokeratins are located in the intracytoplasmic cytoskeleton of epithelial tissues and their neoplasms, including the lungs, ovary and breast. Each keratin filament consists of at least one type I and one type II keratin chain, which then assemble to form a cytoskeletal network, extending from the surface of the nucleus to the cell membrane. The expression of a particular type of cytokeratin depends mainly on the type of epithelium and the development stage of the cell, including its corresponding malignant state. Immunohistochemical analysis of cytokeratin profiles is therefore a valuable tool for diagnosis and characterization, and this particular antibody could be useful for the evaluation of some stratified epithelia which express cytokeratin 17, but not cytokeratin 7. This item is reported as suitable for use in immunocytochemistry, see Bartek, J. et al. for details.
 Form/Format    Purified
Purified IgG - liquid
 Concentration    IgG concentration 1.0mg/ml (lot specific)
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 Perservative Stabilisers    0.09% Sodium Azide (NaN3)
Preparation
 Immunogen    HeLa cell cytoskeleton preparation.
Histology Positive Control Tissue
 Target Species    Human
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 Preparation and Storage    Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
 Other Notes    Small volumes of anti-KRT17 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-KRT17 antibody

   MBS214467 specifically recognises a unique epitope shared by the intermediate filament keratins, cytokeratin 7 and cytokeratin 17, a 54kDa type II basic cytokeratin, and 46kDa type I acidic cytokeratin respectively. Cytokeratins are located in the intracytoplasmic cytoskeleton of epithelial tissues and their neoplasms, including the lungs, ovary and breast. Each keratin filament consists of at least one type I and one type II keratin chain, which then assemble to form a cytoskeletal network, extending from the surface of the nucleus to the cell membrane. The expression of a particular type of cytokeratin depends mainly on the type of epithelium and the development stage of the cell, including its corresponding malignant state. Immunohistochemical analysis of cytokeratin profiles is therefore a valuable tool for diagnosis and characterization, and this particular antibody could be useful for the evaluation of some stratified epithelia which express cytokeratin 17, but not cytokeratin 7. MBS214467 is reported as suitable for use in immunocytochemistry, see Bartek, J. et al. for details.
 Applications Tested/Suitable for anti-KRT17 antibody   

Immunoprecipitation (IP), Immunohistology Paraffin*, Western Blot (WB)

 Application Notes for anti-KRT17 antibody    Western Blot: This item detects bands of approximately 54kDa and 46kDa in HeLa cytoskeleton cell lysates under reducing conditions.
Immunohistology - Paraffin: Minimum Dilution: 20; Maximum Dilution: 30ug/ml; Application Note: This product requires protein digestion pre-treatment of paraffin sections e.g. trypsin or pronase.
Western Blotting: Minimum Dilution: 2; Maximum Dilution: 3ug/ml
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NCBI/Uniprot data below describe general gene information for KRT17. It may not necessarily be applicable to this product.
 NCBI GI #    4557701
 NCBI GeneID    3872
 NCBI Accession #    NP_000413.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000422.2 [Other Products]
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 UniProt Secondary Accession #    Q6IP98; Q8N1P6; A5Z1M9; A5Z1N0; A5Z1N1; A5Z1N2; A6NDV6; A6NKQ2 [Other Products]
 UniProt Related Accession #    Q04695 [Other Products]
 Molecular Weight    48,106 Da [Similar Products]
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 NCBI Official Full Name    keratin, type I cytoskeletal 17
 NCBI Official Synonym Full Names    keratin 17, type I
 NCBI Official Symbol    KRT17 [Similar Products]
 NCBI Official Synonym Symbols   
PC; K17; PC2; PCHC1
[Similar Products]
 NCBI Protein Information    keratin, type I cytoskeletal 17; 39.1; CK-17; cytokeratin-17; keratin 17 epitope S1; keratin 17 epitope S2; keratin 17 epitope S4
 UniProt Protein Name    Keratin, type I cytoskeletal 17
 UniProt Synonym Protein Names   
39.1; Cytokeratin-17; CK-17; Keratin-17; K17
 Protein Family    Keratin
 UniProt Gene Name    KRT17 [Similar Products]
 UniProt Synonym Gene Names    CK-17; K17 [Similar Products]
 UniProt Entry Name    K1C17_HUMAN
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 NCBI Summary for KRT17    This gene encodes the type I intermediate filament chain keratin 17, expressed in nail bed, hair follicle, sebaceous glands, and other epidermal appendages. Mutations in this gene lead to Jackson-Lawler type pachyonychia congenita and steatocystoma multiplex. [provided by RefSeq, Aug 2008]
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 UniProt Comments for KRT17    K17: a type I cytoskeletal keratin. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. There are two types of cytoskeletal and microfibrillar keratin: type I (acidic; 40-55 kDa) [K9 to K20] and type II (neutral to basic; 56-70 kDa) [K1 to K8]. Both a basic and an acidic keratin are required for filament assembly. Generally associates with K6.

Protein type: Cytoskeletal

Chromosomal Location of Human Ortholog: 17q21.2

Cellular Component: cytoplasm; intermediate filament

Molecular Function: MHC class II receptor activity; protein binding; structural constituent of cytoskeleton; MHC class II protein binding

Biological Process: positive regulation of hair follicle development; epidermis development; hair follicle morphogenesis; positive regulation of translation; keratinization; intermediate filament organization; signal transduction; positive regulation of cell growth

Disease: Steatocystoma Multiplex; Pachyonychia Congenita 2
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 Research Articles on KRT17    1. Report overexpression of keratin 17 in premalignant and malignant squamous lesions of the cervix.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-KRT17 antibodyDiseases associated with anti-KRT17 antibody
 Products by Pathway  Pathway Diagram
 EGFR1 Signaling Pathway antibodies  EGFR1 Signaling Pathway Diagram
 Glucocorticoid Receptor Regulatory Network Pathway antibodies  Glucocorticoid Receptor Regulatory Network Pathway Diagram
 Disease Name  Pubmed Publications
 Pachyonychia Congenita Antibodies  >24 publications with KRT17 and Pachyonychia Congenita
 Carcinoma, Squamous Cell Antibodies  >9 publications with KRT17 and Carcinoma, Squamous Cell
 Adenocarcinoma Antibodies  >7 publications with KRT17 and Adenocarcinoma
 Breast Neoplasms Antibodies  >6 publications with KRT17 and Breast Neoplasms
 Esophageal Squamous Cell Carcinoma Antibodies  >3 publications with KRT17 and Esophageal Squamous Cell Carcinoma
 Cell Transformation, Neoplastic Antibodies  >2 publications with KRT17 and Cell Transformation, Neoplastic
 Uterine Neoplasms Antibodies  >2 publications with KRT17 and Uterine Neoplasms
 Uterine Cervical Neoplasms Antibodies  >2 publications with KRT17 and Uterine Cervical Neoplasms
 Precancerous Conditions Antibodies  >2 publications with KRT17 and Precancerous Conditions
 Carcinoma, Basal Cell Antibodies  >2 publications with KRT17 and Carcinoma, Basal Cell
Organs/Tissues associated with anti-KRT17 antibody
 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >18 publications with KRT17 and Skin
 Mouth Antibodies  >4 publications with KRT17 and Mouth
 Lymph Antibodies  >2 publications with KRT17 and Lymph
 Mammary Gland Antibodies  >2 publications with KRT17 and Mammary Gland
 Lymph Node Antibodies  >2 publications with KRT17 and Lymph Node
 Bone Antibodies  >2 publications with KRT17 and Bone
 Cervix Antibodies  >2 publications with KRT17 and Cervix
 Bladder Antibodies  >1 publications with KRT17 and Bladder
 Prostate Antibodies  >1 publications with KRT17 and Prostate
 Muscle Antibodies  >1 publications with KRT17 and Muscle
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