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anti-KRT8 antibody :: Mouse CYTOKERATIN Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS210038 anti-KRT8 antibody
Unit / Price
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 Product Name   

CYTOKERATIN (KRT8), Monoclonal Antibody

★Popular Item★
 Also Known As   


 Product Gene Name   

anti-KRT8 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    148060
 3D Structure    ModBase 3D Structure for P05787
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    Lu-5
 Host    Mouse
 Species Reactivity    Bovine, Chicken, Horse, Rat, Xenopus
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 Specificity    Clone Lu-5 recognizes an intracytoplasmic, formaldehyde-resistant epitope on the surface of cytokeratin filaments.
 Form/Format    Concentrated Tissue Culture Supernatant - lyophilised
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 Reconstitution    Reconstitute with 0.5ml distilled water. Care should be taken during reconstitution as the protein may appear as a film at the bottom of the vial. MyBioSource recommends that the vial is gently mixed after reconstitution.
Perservative Stabilisers
 Immunogen    Human Lung Cancer Cell Line
Histology Positive Control Tissue
 Target Species    Human
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 Preparation and Storage    Prior to reconstitution store at 4 degree C. After reconstitution store at 4 degree C or -20 degree C. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 12 months from date of reconstitution.
 Other Notes    Small volumes of anti-KRT8 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-KRT8 antibody

   Clone Lu-5 recognizes an intracytoplasmic, formaldehyde-resistant epitope on the surface of cytokeratin filaments.
 Applications Tested/Suitable for anti-KRT8 antibody   

Immunohistology Frozen, Immunohistology Paraffin*

 Application Notes for anti-KRT8 antibody    Immunohistology - Frozen: Minimum Dilution: 1/500; Maximum Dilution: 1/1000;
Immunohistology - Paraffin: Minimum Dilution: 1/200; Application Note: This product requires protein digestion pre-treatment of paraffin sections. Proteinase K is recommended for this purpose.
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NCBI/Uniprot data below describe general gene information for KRT8. It may not necessarily be applicable to this product.
 NCBI GI #    1419564
 NCBI GeneID    3856
 NCBI Accession #    CAA67203.1 [Other Products]
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 UniProt Primary Accession #    P05787 [Other Products]
 UniProt Secondary Accession #    Q14099; Q14716; Q14717; Q53GJ0; Q6DHW5; Q6GMY0; Q6P4C7; Q96J60; A8K4H3; B0AZN5; F8VXB4 [Other Products]
 UniProt Related Accession #    P05787 [Other Products]
 Molecular Weight    56,608 Da [Similar Products]
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 NCBI Official Full Name    cytokeratin
 NCBI Official Synonym Full Names    keratin 8, type II
 NCBI Official Symbol    KRT8 [Similar Products]
 NCBI Official Synonym Symbols   
K8; KO; CK8; CK-8; CYK8; K2C8; CARD2
[Similar Products]
 NCBI Protein Information    keratin, type II cytoskeletal 8; cytokeratin 8; cytokeratin-8; type-II keratin Kb8
 UniProt Protein Name    Keratin, type II cytoskeletal 8
 UniProt Synonym Protein Names   
Cytokeratin-8; CK-8; Keratin-8; K8; Type-II keratin Kb8
 Protein Family    Keratin
 UniProt Gene Name    KRT8 [Similar Products]
 UniProt Synonym Gene Names    CYK8; CK-8; K8 [Similar Products]
 UniProt Entry Name    K2C8_HUMAN
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 NCBI Summary for KRT8    This gene is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. The product of this gene typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]
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 UniProt Comments for KRT8    K8: a type II cytoskeletal keratin. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Phosphorylation of keratins at specific sites affects their organization, assembly dynamics, and their interaction with signaling molecules. Phsophorylated by p38 kinase, regulating cellular keratin filament reorganization. Phosphorylation on serine residues is enhanced during EGF stimulation and mitosis. Mutation of this protein is a risk factor for cryptogenic liver failure.

Protein type: Cytoskeletal

Chromosomal Location of Human Ortholog: 12q13

Cellular Component: nucleoplasm; dystrophin-associated glycoprotein complex; intermediate filament cytoskeleton; costamere; nuclear matrix; keratin filament; cytoplasm; intermediate filament; intercellular junction; nucleus; Z disc; sarcolemma

Molecular Function: protein binding; protein complex binding; structural molecule activity

Biological Process: tumor necrosis factor-mediated signaling pathway; viral reproduction; response to other organism; sarcomere organization; response to hydrostatic pressure

Disease: Cirrhosis, Familial
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 Research Articles on KRT8    1. This is the first time intestinal cells have been suggested also functionally impaired by K8/K18 mutations.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-KRT8 antibodyDiseases associated with anti-KRT8 antibody
 Products by Pathway  Pathway Diagram
 EGFR1 Signaling Pathway antibodies  EGFR1 Signaling Pathway Diagram
 Signaling Mediated By P38-alpha And P38-beta Pathway antibodies  Signaling Mediated By P38-alpha And P38-beta Pathway Diagram
 Disease Name  Pubmed Publications
 Liver Diseases Antibodies  >36 publications with KRT8 and Liver Diseases
 Adenocarcinoma Antibodies  >17 publications with KRT8 and Adenocarcinoma
 Breast Neoplasms Antibodies  >16 publications with KRT8 and Breast Neoplasms
 Neoplasm Metastasis Antibodies  >14 publications with KRT8 and Neoplasm Metastasis
 Liver Cirrhosis Antibodies  >10 publications with KRT8 and Liver Cirrhosis
 Disease Models, Animal Antibodies  >10 publications with KRT8 and Disease Models, Animal
 Liver Neoplasms Antibodies  >10 publications with KRT8 and Liver Neoplasms
 Fibrosis Antibodies  >9 publications with KRT8 and Fibrosis
 Necrosis Antibodies  >8 publications with KRT8 and Necrosis
 Drug-Induced Liver Injury Antibodies  >6 publications with KRT8 and Drug-Induced Liver Injury
Organs/Tissues associated with anti-KRT8 antibody
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >48 publications with KRT8 and Liver
 Skin Antibodies  >17 publications with KRT8 and Skin
 Embryonic Tissue Antibodies  >14 publications with KRT8 and Embryonic Tissue
 Kidney Antibodies  >9 publications with KRT8 and Kidney
 Mouth Antibodies  >8 publications with KRT8 and Mouth
 Lung Antibodies  >7 publications with KRT8 and Lung
 Bone Antibodies  >7 publications with KRT8 and Bone
 Prostate Antibodies  >6 publications with KRT8 and Prostate
 Lymph Antibodies  >6 publications with KRT8 and Lymph
 Lymph Node Antibodies  >6 publications with KRT8 and Lymph Node
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