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anti-CALCA antibody :: Calcitonin Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS660034 anti-CALCA antibody
Unit / Price
1 mg  /  $660 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Calcitonin (CALCA), Monoclonal Antibody

 Also Known As   

Monoclonal mouse anti-human calcitonin

 Product Gene Name   

anti-CALCA antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    114130
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 Clonality    Monoclonal
 Isotype    IgG1 for MAbs 24B2, 13F2, 13G11, 14A2, 24B2
IgG2a for MAb 13B9
IgG2b for MAb 16B5
 Clone Number    13B9, 24B2; New MAbs: 13F2, 13G11, 14A2, 16B5
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 Specificity    Human calcitonin and prdegree Calcitonin
 Purity/Purification    Chromatography on protein A Sepharose
 Form/Format    PBS, pH 7.4, 0.1 % sodium azide (NaN3)
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 Clone Note    Hybridoma clones have been derived from hybridization of Sp2/0 myeloma cells with spleen cells of Balb/c mice immunized with calcitonin conjugated with carrier protein.
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 Preparation and Storage    4 degree C
 Other Notes    Small volumes of anti-CALCA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-CALCA antibody   

ELISA (EIA), Western Blot (WB)

 Application Notes for anti-CALCA antibody    Detection of human calcitonin in ELISA.
All MAbs can also be used for prdegree Calcitonin detection in Western blotting after SDS-electrophoresis in reducing conditions.

Recommended pairs for sandwich immunoassay (capture - detection) : 13B9 - 13F2, 24B2 - 13B9
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NCBI/Uniprot data below describe general gene information for CALCA. It may not necessarily be applicable to this product.
 NCBI GI #    179820
 NCBI GeneID    796
 NCBI Accession #    AAA58403.1 [Other Products]
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 UniProt Secondary Accession #    Q13935; Q13937; Q52LX7; B7ZL39 [Other Products]
 UniProt Related Accession #    P01258; P06881 [Other Products]
 Molecular Weight    13,898 Da [Similar Products]
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 NCBI Official Full Name    calcitonin
 NCBI Official Synonym Full Names    calcitonin-related polypeptide alpha
 NCBI Official Symbol    CALCA [Similar Products]
 NCBI Official Synonym Symbols   
CT; KC; CGRP; CALC1; CGRP1; CGRP-I
[Similar Products]
 NCBI Protein Information    calcitonin; calcitonin gene-related peptide 1; katacalcin; calcitonin 1; alpha-type CGRP; calcitonin gene-related peptide I; calcitonin/calcitonin-related polypeptide, alpha
 UniProt Protein Name    Calcitonin
 UniProt Synonym Protein Names   
Calcitonin carboxyl-terminal peptide; CCP; PDN-21
 Protein Family    Calcitonin
 UniProt Gene Name    CALCA [Similar Products]
 UniProt Synonym Gene Names    CALC1; CCP [Similar Products]
 UniProt Entry Name    CALC_HUMAN
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 NCBI Summary for CALCA    This gene encodes the peptide hormones calcitonin, calcitonin gene-related peptide and katacalcin by tissue-specific alternative RNA splicing of the gene transcripts and cleavage of inactive precursor proteins. Calcitonin is involved in calcium regulation and acts to regulate phosphorus metabolism. Calcitonin gene-related peptide functions as a vasodilator and as an antimicrobial peptide while katacalcin is a calcium-lowering peptide. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2014]
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 UniProt Comments for CALCA    CALCA: Calcitonin causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones. Belongs to the calcitonin family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 11p15.2

Cellular Component: extracellular space; cell soma; cytoplasm; extracellular region; terminal button; nucleus

Molecular Function: identical protein binding; protein binding; calcitonin receptor binding; hormone activity; protein complex binding; receptor binding

Biological Process: negative regulation of osteoclast differentiation; elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); positive regulation of interleukin-1 alpha production; vasodilation of artery during baroreceptor response to increased systemic arterial blood pressure; response to pain; positive regulation of vasodilation; protein amino acid phosphorylation; G-protein signaling, adenylate cyclase activating pathway; positive regulation of interleukin-8 production; monocyte chemotaxis; leukocyte adhesion; elevation of cytosolic calcium ion concentration; vasculature development; cell-cell signaling; neuropeptide signaling pathway; negative regulation of smooth muscle contraction; receptor internalization; regulation of blood pressure; positive regulation of cAMP biosynthetic process; negative regulation of ossification; feeding behavior; positive regulation of adenylate cyclase activity; negative regulation of blood pressure; negative regulation of bone resorption; inflammatory response; positive regulation of macrophage differentiation; detection of temperature stimulus involved in sensory perception of pain; negative regulation of neurological process; aging; cytosolic calcium ion homeostasis; regulation of heart rate; adenylate cyclase activation; positive regulation of ossification; regulation of systemic arterial blood pressure by neurological process; G-protein coupled receptor internalization; response to heat; endothelial cell proliferation; regulation of inflammatory response; activation of protein kinase activity; endothelial cell migration; negative regulation of transcription, DNA-dependent; embryo implantation
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 Research Articles on CALCA    1. Procalcitonin of 0.2 ng/mL or greater was demonstrated to be very specific for sepsis among patients with aneurysmal subarachnoid hemorrhage.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CALCA antibodyPathways associated with anti-CALCA antibody
 Reference Product  PubMed Publications
 RAMP1 antibody  >2 publications with CALCA and RAMP1
 POMC antibody  >1 publications with CALCA and POMC
 IAPP antibody  >1 publications with CALCA and IAPP
 ADM antibody  >1 publications with CALCA and ADM
 CALCRL antibody  >1 publications with CALCA and CALCRL
 Products by Pathway  Pathway Diagram
 Amyloids Pathway antibodies  Amyloids Pathway Diagram
 Calcitonin-like Ligand Receptors Pathway antibodies  Calcitonin-like Ligand Receptors Pathway Diagram
 Class B/2 (Secretin Family Receptors) Pathway antibodies  Class B/2 (Secretin Family Receptors) Pathway Diagram
 Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies  Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Endothelin Pathway antibodies  Endothelin Pathway Diagram
 G Alpha (s) Signalling Events Pathway antibodies  G Alpha (s) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 Metabolic Disorders Of Biological Oxidation Enzymes Pathway antibodies  Metabolic Disorders Of Biological Oxidation Enzymes Pathway Diagram
Diseases associated with anti-CALCA antibodyOrgans/Tissues associated with anti-CALCA antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >11 publications with CALCA and Inflammation
 Hypertension Antibodies  >4 publications with CALCA and Hypertension
 Neurogenic Inflammation Antibodies  >4 publications with CALCA and Neurogenic Inflammation
 Migraine Disorders Antibodies  >4 publications with CALCA and Migraine Disorders
 Headache Antibodies  >4 publications with CALCA and Headache
 Pain Antibodies  >4 publications with CALCA and Pain
 Kidney Diseases Antibodies  >3 publications with CALCA and Kidney Diseases
 Edema Antibodies  >2 publications with CALCA and Edema
 Necrosis Antibodies  >1 publications with CALCA and Necrosis
 Wounds and Injuries Antibodies  >1 publications with CALCA and Wounds and Injuries
 Organ/Tissue Name  Pubmed Publications
 Thyroid Antibodies  >11 publications with CALCA and Thyroid
 Brain Antibodies  >8 publications with CALCA and Brain
 Mixed Antibodies  >1 publications with CALCA and Mixed
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