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anti-CALM2 antibody :: Mouse Calmodulin Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS140218 anti-CALM2 antibody
Unit / Price
0.005 mg  /  $140 +1 FREE 8GB USB
0.02 mg  /  $205 +1 FREE 8GB USB
0.1 mg  /  $505 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Calmodulin (CALM2), Monoclonal Antibody

★Popular Item★
 Also Known As   

Mouse Anti Human Calmodulin

 Product Synonym Names    Calmodulin Antibody; Calmodulin, Mouse Anti Human; Calmodulin; CaM; CALM2; PHKD; CAMII; PHKD2; calmodulin 2; phosphorylase kinase delta; Calmodulin
 Product Gene Name   

anti-CALM2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    114180
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 Clonality    Monoclonal
 Isotype    IgG2a heavy chain and kappa light chain
 Clone Number    PJ4D8AT
 Host    Mouse
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 Form/Format    1mg/ml containing PBS, pH-7.4, & 0.1% Sodium Azide.
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 Immunogen    Anti-human Calmodulin mAb is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with recombinant human Calmodulin amino acids 1-149 purified from E Coli.
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 Preparation and Storage    For periods up to 1 month store at 4 degree C, for longer periods of time, store at -20 degree C. Prevent freeze thaw cycles.
12 months at -20 degree C. 1 month at 4 degree C.
 Other Notes    Small volumes of anti-CALM2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CALM2 antibody

   Introduction: Calmodulin (CaM) is an intracellular receptor protein for Ca2+-ions. It activates the myosin light chain kinase which is the catalyst of myosin phosphorylation. CaM participates in the activation of enzymes such as cyclic nucleotide- dependent phosphodiesterase, calcineurin, ATPase, Myosin Light Chain Kinases, and CAM kinase.
 Product Categories/Family for anti-CALM2 antibody    MONOCLONAL/POLYCLONAL ANTIBODIES, MISCELLANEOUS ANTIBODIES; Monoclonal Antibodies
 Applications Tested/Suitable for anti-CALM2 antibody   

ELISA (EIA), Western Blot (WB)

 Application Notes for anti-CALM2 antibody    Calmodulin antibody has been tested by ELISA and Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended dilution range for Western blot analysis is 1:500 ~ 1,000. Recommended starting dilution is 1:500.
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NCBI/Uniprot data below describe general gene information for CALM2. It may not necessarily be applicable to this product.
 NCBI GI #    4502549
 NCBI GeneID    805
 NCBI Accession #    NP_001734.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001743.4 [Other Products]
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 UniProt Secondary Accession #    P02593; P70667; P99014; Q13942; Q53S29; Q61379; Q61380; Q96HK3 [Other Products]
 UniProt Related Accession #    P62158 [Other Products]
 Molecular Weight    16,838 Da [Similar Products]
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 NCBI Official Full Name    calmodulin
 NCBI Official Synonym Full Names    calmodulin 2 (phosphorylase kinase, delta)
 NCBI Official Symbol    CALM2 [Similar Products]
 NCBI Official Synonym Symbols   
PHKD; CAMII; PHKD2
[Similar Products]
 NCBI Protein Information    calmodulin; LP7057 protein; caM; phosphorylase kinase delta; prepro-calmodulin 2
 UniProt Protein Name    Calmodulin
 Protein Family    Calmodulin
 UniProt Gene Name    CALM1 [Similar Products]
 UniProt Synonym Gene Names    CALM; CAM; CAM1; CaM [Similar Products]
 UniProt Entry Name    CALM_HUMAN
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 NCBI Summary for CALM2    This gene is a member of the calmodulin gene family. There are three distinct calmodulin genes dispersed throughout the genome that encode the identical protein, but differ at the nucleotide level. Calmodulin is a calcium binding protein that plays a role in signaling pathways, cell cycle progression and proliferation. Several infants with severe forms of long-QT syndrome (LQTS) who displayed life-threatening ventricular arrhythmias together with delayed neurodevelopment and epilepsy were found to have mutations in either this gene or another member of the calmodulin gene family (PMID:23388215). Mutations in this gene have also been identified in patients with less severe forms of LQTS (PMID:24917665), while mutations in another calmodulin gene family member have been associated with catecholaminergic polymorphic ventricular tachycardia (CPVT)(PMID:23040497), a rare disorder thought to be the cause of a significant fraction of sudden cardiac deaths in young individuals. Pseudogenes of this gene are found on chromosomes 10, 13, and 17. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2015]
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 UniProt Comments for CALM2    Calmodulin: a calcium-binding small regulatory protein that mediates the control of a large number of enzymes by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. Has four functional calcium-binding domains. Phosphorylation and ubiquitination result in a decreased activity.

Protein type: Calcium-binding

Chromosomal Location of Human Ortholog: 14q32.11

Cellular Component: nucleoplasm; spindle pole; centrosome; sarcomere; growth cone; spindle microtubule; cytoplasm; plasma membrane; extracellular region; cytosol; nucleus; vesicle

Molecular Function: protein domain specific binding; nitric-oxide synthase regulator activity; titin binding; calcium ion binding; calcium-dependent protein binding; protein kinase binding; protein serine/threonine kinase activator activity; protein binding; N-terminal myristoylation domain binding; phospholipase binding; thioesterase binding; type 3 metabotropic glutamate receptor binding; phosphoinositide 3-kinase binding; nitric-oxide synthase binding; adenylate cyclase binding

Biological Process: positive regulation of phosphoprotein phosphatase activity; phototransduction, visible light; inositol phosphate metabolic process; nerve growth factor receptor signaling pathway; pathogenesis; signal transduction; nitric oxide metabolic process; positive regulation of protein amino acid dephosphorylation; synaptic transmission; substantia nigra development; platelet degranulation; muscle contraction; positive regulation of cyclic nucleotide metabolic process; response to corticosterone stimulus; epidermal growth factor receptor signaling pathway; mitochondrion organization and biogenesis; platelet activation; glycogen catabolic process; fibroblast growth factor receptor signaling pathway; regulation of heart rate; positive regulation of nitric-oxide synthase activity; organelle organization and biogenesis; response to amphetamine; adenylate cyclase activation; glucose metabolic process; positive regulation of protein amino acid autophosphorylation; regulation of cytokinesis; rhodopsin mediated signaling; G-protein coupled receptor protein signaling pathway; regulation of rhodopsin mediated signaling; phospholipase C activation; carbohydrate metabolic process; innate immune response; positive regulation of cyclic-nucleotide phosphodiesterase activity; detection of calcium ion; regulation of nitric-oxide synthase activity; blood coagulation; vascular endothelial growth factor receptor signaling pathway; response to calcium ion

Disease: Long Qt Syndrome 14; Ventricular Tachycardia, Catecholaminergic Polymorphic, 4
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 Research Articles on CALM2    1. CaM-2-ext interacts biochemically with the C-terminus of Ca(v)2.3 similar to the classical CaM-2 as shown by co-immunoprecipitation
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-CALM2 antibodyDiseases associated with anti-CALM2 antibody
 Products by Pathway  Pathway Diagram
 Activation Of Ca-permeable Kainate Receptor Pathway antibodies  Activation Of Ca-permeable Kainate Receptor Pathway Diagram
 Activation Of CaMK IV Pathway antibodies  Activation Of CaMK IV Pathway Diagram
 Activation Of Kainate Receptors Upon Glutamate Binding Pathway antibodies  Activation Of Kainate Receptors Upon Glutamate Binding Pathway Diagram
 Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway antibodies  Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Adrenergic Signaling In Cardiomyocytes Pathway antibodies  Adrenergic Signaling In Cardiomyocytes Pathway Diagram
 Adrenergic Signaling In Cardiomyocytes Pathway antibodies  Adrenergic Signaling In Cardiomyocytes Pathway Diagram
 Alcoholism Pathway antibodies  Alcoholism Pathway Diagram
 Alcoholism Pathway antibodies  Alcoholism Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Disease Name  Pubmed Publications
 Heart Diseases Antibodies  >3 publications with CALM2 and Heart Diseases
 Cardiovascular Diseases Antibodies  >3 publications with CALM2 and Cardiovascular Diseases
 Lung Neoplasms Antibodies  >1 publications with CALM2 and Lung Neoplasms
 Pain Antibodies  >1 publications with CALM2 and Pain
 Abnormalities, Drug-Induced Antibodies  >1 publications with CALM2 and Abnormalities, Drug-Induced
 Poisoning Antibodies  >1 publications with CALM2 and Poisoning
 Kidney Diseases Antibodies  >1 publications with CALM2 and Kidney Diseases
 Phencyclidine Abuse Antibodies  >1 publications with CALM2 and Phencyclidine Abuse
 Marijuana Abuse Antibodies  >1 publications with CALM2 and Marijuana Abuse
 Depressive Disorder Antibodies  >1 publications with CALM2 and Depressive Disorder
Organs/Tissues associated with anti-CALM2 antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >5 publications with CALM2 and Blood
 Heart Antibodies  >3 publications with CALM2 and Heart
 Bone Antibodies  >3 publications with CALM2 and Bone
 Brain Antibodies  >3 publications with CALM2 and Brain
 Muscle Antibodies  >2 publications with CALM2 and Muscle
 Eye Antibodies  >2 publications with CALM2 and Eye
 Lung Antibodies  >2 publications with CALM2 and Lung
 Connective Tissue Antibodies  >1 publications with CALM2 and Connective Tissue
 Pituitary Gland Antibodies  >1 publications with CALM2 and Pituitary Gland
 Vascular Antibodies  >1 publications with CALM2 and Vascular
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