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anti-CAST antibody :: Mouse Calpastatin Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS531090 anti-CAST antibody
Unit / Price
0.1 mL  /  $685 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Calpastatin (CAST), Monoclonal Antibody

 Also Known As   

Calpastatin antibody

 Product Synonym Names    Monoclonal Calpastatin; Anti-Calpastatin
 Product Gene Name   

anti-CAST antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    114090
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    1F7E3D10
 Host    Mouse
 Species Reactivity    Bovine, Human, Pig, Rat
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 Specificity    Bovine
 Form/Format    PBS-diluted ascites containing 0.05% NaN3.
 Concentration    1.0 mg/ml (lot specific)
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 Biological Significance    Calpastatin, a specific endogenous inhibitor of calpain, has a predicted molecular weight of ~77 kDa and an internal repeat of four homologous domains which allow it to inhibit multiple calpain molecules simultaneously. It functions by binding to calpain when calpain binds calcium.
 Biohazard Information    This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product.
 Immunogen    Calpastatin antibody was raised in mouse using purified bovine skeletal muscle 80 kDa subunit of m-Calpastatin as the immunogen.
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 Preparation and Storage    Aliquot and store at -20 degree C. Avoid repeated freeze/thaw cycles.
 Other Notes    Small volumes of anti-CAST antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-CAST antibody

   Mouse monoclonal Calpastatin antibody
 Product Categories/Family for anti-CAST antibody    Proteases, Inhibitors, & Enzymes
 Applications Tested/Suitable for anti-CAST antibody   

Immunocytochemistry (ICC), Western Blot (WB)

 Application Notes for anti-CAST antibody    ICC: 1:200, WB: 1:5,000
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NCBI/Uniprot data below describe general gene information for CAST. It may not necessarily be applicable to this product.
 NCBI GI #    180975
 NCBI Accession #    AAA52066.1 [Other Products]
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 UniProt Secondary Accession #    O95360; Q05DE8; Q7Z4K0; Q96D08; Q9H1Z5; B7Z468; G5E946; G5E9D3 [Other Products]
 Molecular Weight    82,437 Da [Similar Products]
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 NCBI Official Full Name    calpastatin, partial
 UniProt Protein Name    Calpastatin
 UniProt Synonym Protein Names   
Calpain inhibitor; Sperm BS-17 component
 Protein Family    Calpastatin
 UniProt Gene Name    CAST [Similar Products]
 UniProt Entry Name    ICAL_HUMAN
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 UniProt Comments for CAST    calpastatin: Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue. Belongs to the protease inhibitor I27 (calpastatin) family. 7 isoforms of the human protein are produced by alternative splicing.

Protein type: Inhibitor

Chromosomal Location of Human Ortholog: 5q15

Cellular Component: membrane; cytoplasm; cytosol

Molecular Function: protein binding; endopeptidase inhibitor activity; cysteine protease inhibitor activity

Disease: Peeling Skin With Leukonychia, Acral Punctate Keratoses, Cheilitis, And Knuckle Pads
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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