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anti-CNN1 antibody :: Mouse Calponin Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS370013
Unit / Price
5 Control Slides  /  $130 +1 FREE 8GB USB
0.1 mL (Concentrate)  /  $170 +1 FREE 8GB USB
3 ml (Prediluted)  /  $190 +1 FREE 8GB USB
7 ml (Prediluted)  /  $250 +1 FREE 8GB USB
0.5 mL (Concentrate)  /  $315 +1 FREE 8GB USB
15 ml (Prediluted)  /  $395 +1 FREE 8GB USB
1 mL (Concentrate)  /  $425 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Calponin (CNN1), Monoclonal Antibody

 Also Known As   


 Product Gene Name   

anti-CNN1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 19; NC_000019.9 (11649579..11661138). Location: 19p13.2-p13.1
 OMIM    600806
 3D Structure    ModBase 3D Structure for P51911
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 Clonality    Monoclonal
 Isotype    IgG1/K
 Clone Number    CALP-A6
 Host    Mouse
 Species Reactivity    Human, Canine, Feline
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 Form/Format    Anti-Calponin (CALP-A6) is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
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 Control    Appendix, Uterus, Leiomyoma
 Localization    Cytoplasmic
 Reactivity Note    Paraffin, Frozen
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 Preparation and Storage    Store at 2 to 8 degree C in the dark.
 Other Notes    Small volumes of anti-CNN1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CNN1 antibody

   Calponin is a 34 kDa polypeptide that interacts with actin, tropomyosin, and calmodulin. It is involved in smooth-muscle contraction mechanisms and is restricted exclusively to smooth-muscle tissue. Calponin is a calcium-binding protein. Calponin tonically inhibits the ATPase activity of myosin in smooth muscle. Phosphorylation of calponin by a protein kinase (which is dependent upon calcium binding to calmodulin) releases the calponin's inhibition of the smooth-muscle ATPase. Calponin has been found to be useful in differentiating benign sclerosing lesions of the breast from Carcinoma. Calponin positivity has also been noted in Malignant Myoepithelioma and Pleomorphic Adenoma of Salivary Gland origin, as well as in Angiomatoid Malignant Fibrous Histiocytoma.
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 Dilution Information of anti-CNN1 antibody    anti-CNN1 antibody Dilution Information image
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 Immunohistochemistry (IHC) of anti-CNN1 antibody    anti-CNN1 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for CNN1. It may not necessarily be applicable to this product.
 NCBI GI #    1783205
 NCBI GeneID    1264
 NCBI Accession #    BAA04231.1 [Other Products]
 NCBI GenBank Nucleotide #    D17408.1 [Other Products]
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 UniProt Primary Accession #    P51911 [Other Products]
 UniProt Secondary Accession #    O00638; Q15416; Q8IY93; Q99438; B2R868 [Other Products]
 UniProt Related Accession #    P51911; Q53FP8 [Other Products]
 Molecular Weight    33,170 Da [Similar Products]
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 NCBI Official Full Name    calponin
 NCBI Official Synonym Full Names    calponin 1, basic, smooth muscle
 NCBI Official Symbol    CNN1 [Similar Products]
 NCBI Official Synonym Symbols   
SMCC; Sm-Calp
[Similar Products]
 NCBI Protein Information    calponin-1; basic calponin; calponins, basic; calponin H1, smooth muscle
 UniProt Protein Name    Calponin-1
 UniProt Synonym Protein Names   
Basic calponin; Calponin H1, smooth muscle
 Protein Family    Calponin
 UniProt Gene Name    CNN1 [Similar Products]
 UniProt Entry Name    CNN1_HUMAN
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 UniProt Comments for CNN1    Function: Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity

Subunit structure: Part of cGMP kinase signaling complex at least composed of ACTA2/alpha-actin, CNN1/calponin H1, PLN/phospholamban, PRKG1 and ITPR1

Tissue specificity: Smooth muscle, and tissues containing significant amounts of smooth muscle.

Sequence similarities: Belongs to the calponin family.Contains 3 calponin-like repeats.Contains 1 CH (calponin-homology) domain.
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 Research Articles on CNN1    1. D2-40 immunohistochemistry reliably identifies the myoepithelial cells of breast in a variety of lesions in a pattern similar to that of calponin and p63.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-CNN1 antibodyDiseases associated with anti-CNN1 antibody
 Products by Pathway  Pathway Diagram
 Myometrial Relaxation And Contraction Pathways antibodies  Myometrial Relaxation And Contraction Pathways Diagram
 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >3 publications with CNN1 and Carcinoma
 Neoplasms Antibodies  >3 publications with CNN1 and Neoplasms
 Neoplasms, Experimental Antibodies  >2 publications with CNN1 and Neoplasms, Experimental
 Head and Neck Neoplasms Antibodies  >1 publications with CNN1 and Head and Neck Neoplasms
 Precancerous Conditions Antibodies  >1 publications with CNN1 and Precancerous Conditions
 Neoplasms, Hormone-Dependent Antibodies  >1 publications with CNN1 and Neoplasms, Hormone-Dependent
 Vascular Diseases Antibodies  >1 publications with CNN1 and Vascular Diseases
 Melanoma Antibodies  >1 publications with CNN1 and Melanoma
 Lung Diseases Antibodies  >1 publications with CNN1 and Lung Diseases
 Carcinoma, Squamous Cell Antibodies  >1 publications with CNN1 and Carcinoma, Squamous Cell
Organs/Tissues associated with anti-CNN1 antibody
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >4 publications with CNN1 and Muscle
 Vascular Antibodies  >3 publications with CNN1 and Vascular
 Connective Tissue Antibodies  >2 publications with CNN1 and Connective Tissue
 Nerve Antibodies  >2 publications with CNN1 and Nerve
 Bone Antibodies  >1 publications with CNN1 and Bone
 Lung Antibodies  >1 publications with CNN1 and Lung
 Brain Antibodies  >1 publications with CNN1 and Brain
 Esophagus Antibodies  >1 publications with CNN1 and Esophagus
 Bone Marrow Antibodies  >1 publications with CNN1 and Bone Marrow
 Embryonic Tissue Antibodies  >1 publications with CNN1 and Embryonic Tissue
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