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anti-CBR3 antibody :: Mouse anti-Human Carbonyl Reductase 3 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS607365 anti-CBR3 antibody
Unit / Price
0.1 mL  /  $510 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Carbonyl Reductase 3 (CBR3), Monoclonal Antibody

 Also Known As   

Carbonyl Reductase 3 (CBR3, hCBR3, Carbonyl reductase (NADPH) 3)

 Product Synonym Names    Anti -Carbonyl Reductase 3 (CBR3, hCBR3, Carbonyl reductase (NADPH) 3)
 Product Gene Name   

anti-CBR3 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 21; NC_000021.8 (37507263..37518860). Location: 21q22.2
 OMIM    603608
 3D Structure    ModBase 3D Structure for O75828
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 Clonality    Monoclonal
 Isotype    IgG1,k
 Clone Number    10C298
 Host    Mouse
 Species Reactivity    Human
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 Specificity    Recognizes human Carbonyl Reductase 3 (CBR3, hCBR3, Carbonyl reductase (NADPH) 3).
 Purity/Purification    Affinity Purified
Purified by immunoaffinity chromatography.
 Form/Format    Supplied as a liquid in PBS, pH 7.2, 0.1% sodium azide.
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 Immunogen    Recombinant CBR3 (1-277aa) purified from E. coli
 Hybridoma    Hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice
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 Preparation and Storage    May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile 40-50% glycerol, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
 Other Notes    Small volumes of anti-CBR3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-CBR3 antibody

   Carbonyl reductase 3 (CBR3) is members of the family of short chain dehydrogenases/reductases. Carbonyl reductases are two monomeric carbonyl reductases, carbonyl CBR1 and CBR3. CBR3 catalyzes the reduction of a large number of biologically and pharmacologically active carbonyl compounds to their corresponding alcohols. The enzyme is classified as a monomeric NADPH-dependent oxidoreductase.
 Product Categories/Family for anti-CBR3 antibody    Antibodies; Abs to Enzymes, Reductase
 Applications Tested/Suitable for anti-CBR3 antibody   

ELISA (EL/EIA), Western Blot (WB)

 Application Notes for anti-CBR3 antibody    Suitable for use in ELISA, Western Blotting.
Dilution: ELISA: 1:1000-1:2000
Western Blotting: 1:1000-1:2000
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NCBI/Uniprot data below describe general gene information for CBR3. It may not necessarily be applicable to this product.
 NCBI GI #    119630152
 NCBI GeneID    874
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 UniProt Primary Accession #    O75828 [Other Products]
 UniProt Secondary Accession #    Q6FHP2 [Other Products]
 UniProt Related Accession #    O60874; O75828; Q53F60 [Other Products]
 Molecular Weight    30,850 Da [Similar Products]
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 NCBI Official Full Name    carbonyl reductase 3
 NCBI Official Synonym Full Names    carbonyl reductase 3
 NCBI Official Symbol    CBR3 [Similar Products]
 NCBI Official Synonym Symbols   
hCBR3; SDR21C2
[Similar Products]
 NCBI Protein Information    carbonyl reductase [NADPH] 3; carbonyl reductase [NADPH] 3; OTTHUMP00000109012; carbonyl reductase (NADPH) 3; NADPH-dependent carbonyl reductase 3; short chain dehydrogenase/reductase family 21C, member 2
 UniProt Protein Name    Carbonyl reductase [NADPH] 3
 UniProt Synonym Protein Names   
NADPH-dependent carbonyl reductase 3
 Protein Family    Carbonyl reductase
 UniProt Gene Name    CBR3 [Similar Products]
 UniProt Entry Name    CBR3_HUMAN
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 NCBI Summary for CBR3    Carbonyl reductase 3 catalyzes the reduction of a large number of biologically and pharmacologically active carbonyl compounds to their corresponding alcohols. The enzyme is classified as a monomeric NADPH-dependent oxidoreductase. CBR3 contains three exons spanning 11.2 kilobases and is closely linked to another carbonyl reductase gene - CBR1. [provided by RefSeq]
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 UniProt Comments for CBR3    CBR3: Has low NADPH-dependent oxidoreductase activity towards 4-benzoylpyridine and menadione (in vitro). Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Protein type: Lipid Metabolism - arachidonic acid; Oxidoreductase; EC 1.1.1.184

Chromosomal Location of Human Ortholog: 21q22.2

Cellular Component: nucleoplasm; extracellular space; cytoplasm; cytosol

Molecular Function: 3-keto sterol reductase activity; carbonyl reductase (NADPH) activity

Biological Process: phylloquinone catabolic process; cognition
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 Research Articles on CBR3    1. CBR3 is regulated via NRF2-dependent signaling pathways, a finding and plays an important role in the cellular response to oxidative stress.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-CBR3 antibodyDiseases associated with anti-CBR3 antibody
 Products by Pathway  Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Of Xenobiotics By Cytochrome P450 Pathway antibodies  Metabolism Of Xenobiotics By Cytochrome P450 Pathway Diagram
 Metabolism Of Xenobiotics By Cytochrome P450 Pathway antibodies  Metabolism Of Xenobiotics By Cytochrome P450 Pathway Diagram
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >10 publications with CBR3 and Neoplasms
 Breast Neoplasms Antibodies  >5 publications with CBR3 and Breast Neoplasms
 Drug Toxicity Antibodies  >3 publications with CBR3 and Drug Toxicity
 Lung Neoplasms Antibodies  >2 publications with CBR3 and Lung Neoplasms
 Heart Failure Antibodies  >2 publications with CBR3 and Heart Failure
 Carcinoma Antibodies  >2 publications with CBR3 and Carcinoma
 Neurodegenerative Diseases Antibodies  >1 publications with CBR3 and Neurodegenerative Diseases
 Head and Neck Neoplasms Antibodies  >1 publications with CBR3 and Head and Neck Neoplasms
 Intestinal Diseases Antibodies  >1 publications with CBR3 and Intestinal Diseases
 Central Nervous System Diseases Antibodies  >1 publications with CBR3 and Central Nervous System Diseases
Organs/Tissues associated with anti-CBR3 antibody
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >6 publications with CBR3 and Liver
 Brain Antibodies  >5 publications with CBR3 and Brain
 Lung Antibodies  >4 publications with CBR3 and Lung
 Nerve Antibodies  >2 publications with CBR3 and Nerve
 Kidney Antibodies  >2 publications with CBR3 and Kidney
 Uterus Antibodies  >1 publications with CBR3 and Uterus
 Embryonic Tissue Antibodies  >1 publications with CBR3 and Embryonic Tissue
 Connective Tissue Antibodies  >1 publications with CBR3 and Connective Tissue
 Skin Antibodies  >1 publications with CBR3 and Skin
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