NP_001278413.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
80-200kDa
NCBI Official Full Name
carcinoembryonic antigen-related cell adhesion molecule 5 isoform 1 preproprotein
NCBI Official Synonym Full Names
carcinoembryonic antigen related cell adhesion molecule 5
NCBI Official Synonym Symbols
NCBI Protein Information
carcinoembryonic antigen-related cell adhesion molecule 5
UniProt Protein Name
Carcinoembryonic antigen-related cell adhesion molecule 5
UniProt Synonym Protein Names
Carcinoembryonic antigen; CEA; Meconium antigen 100; CD_antigen: CD66e
UniProt Synonym Gene Names
NCBI Summary for CEA
This gene encodes a cell surface glycoprotein that represents the founding member of the carcinoembryonic antigen (CEA) family of proteins. The encoded protein is used as a clinical biomarker for gastrointestinal cancers and may promote tumor development through its role as a cell adhesion molecule. Additionally, the encoded protein may regulate differentiation, apoptosis, and cell polarity. This gene is present in a CEA family gene cluster on chromosome 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]
UniProt Comments for CEA
Cell surface glycoprotein that plays a role in cell adhesion, intracellular signaling and tumor progression (PubMed:2803308, PubMed:10910050, PubMed:10864933). Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM6 (PubMed:2803308). Plays a role as an oncogene by promoting tumor progression; induces resistance to anoikis of colorectal carcinoma cells (PubMed:10910050).
Product References and Citations for anti-CEA antibody
Siler K, et. al. Biotechnology Therapeutics, 1993, 4(3-4):163-81. Robbins PF, et. al. International Journal of Cancer, 1993, 53(6):892-7. Shi ZR, et. al. Journal of Histochemistry and Cytochemistry, 1994, 42(9):1215-9. Muraro R, et. al. Cancer Research, 1985, 45:5769-80.
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Products associated with anti-CEA antibody
Diseases associated with anti-CEA antibody
Organs/Tissues associated with anti-CEA antibody
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