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anti-Casp3 antibody :: Mouse Caspase-3 (Pro and Active) Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS668032
Unit / Price
0.025 mg  /  $155 +1 FREE 8GB USB
0.1 mg  /  $250 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Caspase-3 (Pro and Active) (Casp3), Monoclonal Antibody

 Also Known As   

Caspase-3 (Pro and Active) Monoclonal Antibody

 Product Gene Name   

anti-Casp3 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for P70677
 Clonality    Monoclonal
 Isotype    Mouse IgG1, Kappa
 Clone Number    ABM1C12
 Host    Mouse
 Species Reactivity    Human (Predicted Reactivity: Mouse, Rat
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 Form/Format    Purified (Liquid)
 Concentration    0.5 mg/ml, 200 l (lot specific)
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 Antigen    Caspase-3 (Pro and Active)
 Immunogen    Full length recombinant Caspase-3 protein was used as the immunogen for this antibody
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 Preparation and Storage    Store antibody at 4 degree C, stable for 6 months. For long-term storage, store at -20 degree C. Avoid repeated freeze and thaw cycles. Expire 1 year from date of purchase.
 Other Notes    Small volumes of anti-Casp3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-Casp3 antibody    Apoptosis
 Applications Tested/Suitable for anti-Casp3 antibody   

Western Blot (WB), Immunohistochemistry (IHC)

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 Western Blot (WB) of anti-Casp3 antibody    Expression analysis of Caspase-3. Anti- Caspase-3 (Clone: ABM1C12) was used at 2 g/ml on Ramos lysates.
anti-Casp3 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-Casp3 antibody    Immunohistochemical analysis of Caspase-3 in normal human colon tissue using Caspase-3 antibody (Clone: ABM1C12) at 5 ug/ml.
anti-Casp3 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) #2 of anti-Casp3 antibody    Immunohistochemical analysis of Caspase-3 in adenocarcinoma of rectum using Caspase-3 antibody (Clone: ABM1C12) at 5 ug/ml.
anti-Casp3 antibody Immunohistochemistry (IHC) #2 (IHC) image
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 Immunohistochemistry (IHC) #3 of anti-Casp3 antibody    Immunohistochemical analysis of Caspase-3 in normal human spleen tissue using Caspase-3 antibody (Clone: ABM1C12) at 5 ug/ml.
anti-Casp3 antibody Immunohistochemistry (IHC) #3 (IHC) image
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 Immunohistochemistry (IHC) #4 of anti-Casp3 antibody    Immunohistochemical analysis of Caspase-3 in squamous cell carcinoma of lungs using Caspase-3 antibody (Clone: ABM1C12) at 5 ug/ml.
anti-Casp3 antibody Immunohistochemistry (IHC) #4 (IHC) image
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NCBI/Uniprot data below describe general gene information for Casp3. It may not necessarily be applicable to this product.
 NCBI GI #    549806822
 NCBI GeneID    12367
 NCBI Accession #    NP_001271338.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001284409.1 [Other Products]
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 UniProt Primary Accession #    P70677 [Other Products]
 UniProt Secondary Accession #    O08668; Q8CHV5; Q9QWI4 [Other Products]
 UniProt Related Accession #    P70677 [Other Products]
 Molecular Weight    31,475 Da [Similar Products]
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 NCBI Official Full Name    caspase-3
 NCBI Official Synonym Full Names    caspase 3
 NCBI Official Symbol    Casp3 [Similar Products]
 NCBI Official Synonym Symbols   
CC3; AC-3; Lice; Yama; mldy; CPP32; SCA-1; CASP-3; CPP-32; Apopain; Caspase-3; A830040C14Rik
[Similar Products]
 NCBI Protein Information    caspase-3; SREBP cleavage activity 1; caspase 3, apoptosis related cysteine protease; cysteine protease CPP32; protein Yama
 UniProt Protein Name    Caspase-3
 UniProt Synonym Protein Names   
Apopain; Cysteine protease CPP32; CPP-32
 Protein Family    Caspase
 UniProt Gene Name    Casp3 [Similar Products]
 UniProt Synonym Gene Names    Cpp32; CASP-3; CPP-32; SCA-1 [Similar Products]
 UniProt Entry Name    CASP3_MOUSE
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 UniProt Comments for Casp3    CASP3: Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop- helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage. Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 17 kDa (p17) and a 12 kDa (p12) subunit. Interacts with BIRC6/bruce. Highly expressed in lung, spleen, heart, liver and kidney. Moderate levels in brain and skeletal muscle, and low in testis. Also found in many cell lines, highest expression in cells of the immune system. Inhibited by isatin sulfonamides. Belongs to the peptidase C14A family.

Protein type: EC 3.4.22.56; Motility/polarity/chemotaxis; Apoptosis; Protease

Cellular Component: cytoplasm; cytosol; nucleus; lipid raft

Molecular Function: cyclin-dependent protein kinase inhibitor activity; peptidase activity; phospholipase A2 activator activity; protein binding; protease binding; hydrolase activity; cysteine-type endopeptidase activity; death receptor binding; protein complex binding; aspartic-type endopeptidase activity; cysteine-type peptidase activity

Biological Process: positive regulation of catalytic activity; apoptosis; positive regulation of apoptosis; heart development; negative regulation of activated T cell proliferation; negative regulation of B cell proliferation; proteolysis; negative regulation of cell cycle; neuron differentiation; learning and/or memory; sensory perception of sound; B cell homeostasis; positive regulation of neuron apoptosis; response to wounding; response to glucose stimulus; erythrocyte differentiation; T cell homeostasis; response to UV; release of cytochrome c from mitochondria; cell fate commitment; negative regulation of cyclin-dependent protein kinase activity; keratinocyte differentiation; neuron apoptosis; induction of apoptosis via death domain receptors; response to hydrogen peroxide; protein processing; induction of apoptosis by oxidative stress; response to DNA damage stimulus; negative regulation of apoptosis
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 Research Articles on Casp3    1. Data indicate that procaspase-3 has a non-apoptotic function; it regulates the secretion of fibronectin and influences morphology, adhesion and migration.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-Casp3 antibodyPathways associated with anti-Casp3 antibody
 Reference Product  PubMed Publications
 Casp9 antibody  >6308 publications with Casp3 and Casp9
 Casp8 antibody  >4626 publications with Casp3 and Casp8
 Xiap antibody  >882 publications with Casp3 and Xiap
 Bcl2 antibody  >805 publications with Casp3 and Bcl2
 Apaf1 antibody  >313 publications with Casp3 and Apaf1
 Birc3 antibody  >41 publications with Casp3 and Birc3
 Dffb antibody  >38 publications with Casp3 and Dffb
 Birc2 antibody  >33 publications with Casp3 and Birc2
 Mapk14 antibody  >17 publications with Casp3 and Mapk14
 Dffa antibody  >4 publications with Casp3 and Dffa
 Products by Pathway  Pathway Diagram
 Activation Of DNA Fragmentation Factor Pathway antibodies  Activation Of DNA Fragmentation Factor Pathway Diagram
 Activation Of Caspases Through Apoptosome-mediated Cleavage Pathway antibodies  Activation Of Caspases Through Apoptosome-mediated Cleavage Pathway Diagram
 Alpha6-Beta4 Integrin Signaling Pathway antibodies  Alpha6-Beta4 Integrin Signaling Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Androgen Receptor Signaling Pathway antibodies  Androgen Receptor Signaling Pathway Diagram
Diseases associated with anti-Casp3 antibodyOrgans/Tissues associated with anti-Casp3 antibody
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >5676 publications with Casp3 and Necrosis
 Nervous System Diseases Antibodies  >4267 publications with Casp3 and Nervous System Diseases
 Inflammation Antibodies  >2702 publications with Casp3 and Inflammation
 Reperfusion Injury Antibodies  >1831 publications with Casp3 and Reperfusion Injury
 Liver Diseases Antibodies  >1819 publications with Casp3 and Liver Diseases
 Brain Ischemia Antibodies  >1365 publications with Casp3 and Brain Ischemia
 Heart Diseases Antibodies  >1249 publications with Casp3 and Heart Diseases
 Breast Neoplasms Antibodies  >1160 publications with Casp3 and Breast Neoplasms
 Kidney Diseases Antibodies  >687 publications with Casp3 and Kidney Diseases
 Nerve Degeneration Antibodies  >599 publications with Casp3 and Nerve Degeneration
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >6327 publications with Casp3 and Brain
 Lung Antibodies  >2599 publications with Casp3 and Lung
 Kidney Antibodies  >1654 publications with Casp3 and Kidney
 Prostate Antibodies  >1058 publications with Casp3 and Prostate
 Eye Antibodies  >1027 publications with Casp3 and Eye
 Skin Antibodies  >890 publications with Casp3 and Skin
 Intestine Antibodies  >747 publications with Casp3 and Intestine
 Embryonic Tissue Antibodies  >677 publications with Casp3 and Embryonic Tissue
 Pancreas Antibodies  >636 publications with Casp3 and Pancreas
 Spinal Cord Antibodies  >540 publications with Casp3 and Spinal Cord
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