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anti-JUP antibody :: Mouse Catenin, gamma Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS4380058
Unit / Price
0.02 mg (With BSA & Azide at 0.2mg/ml)  /  $190 +1 FREE 8GB USB
0.1 mg (With BSA & Azide at 0.2mg/ml)  /  $300 +1 FREE 8GB USB
0.1 mg (Without BSA & Azide at 1mg/ml)  /  $310 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Catenin, gamma (JUP), Monoclonal Antibody

★Popular Item★
 Also Known As   

Catenin, gamma (Cardiomyocyte Marker)

 Product Synonym Names    ARVD12; Catenin (cadherin-associated protein), gamma 80kDa; Catenin gamma; CTNNG; Desmoplakin III; Desmoplakin-3; DP3; DPIII; Junction Plakoglobin; PDGB; PKGB
 Product Gene Name   

anti-JUP antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for P14923
 Clonality    Monoclonal
 Isotype    IgG1, kappa
 Clone Number    CTNG/1483
 Host    Mouse
 Species Reactivity    Human. Others not known.
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 Specificity    It recognizes a protein of 80-87kDa, identified as gamma-catenin. The catenins (alpha, beta, gamma and delta) are ubiquitously expressed, cytoplasmic proteins that associate with E-cadherin at cellular junctions. Catenin/cadherin complexes play an important role in mediating cellular adhesion. alpha T-catenin, also referred to as VR22, is a 895-amino acid protein that is most abundantly expressed in cardio-myocytes and in the peritubular myoid cells of the testis. alpha T-catenin binds to alpha E-catenin as well as to beta-catenin, and it functions to inhibit Wnt signaling. CTNNA3, the gene that encodes for alpha-T-catenin, is located on chromosome 10, and mutations in this gene show a strong correlation to late-onset Alzheimers disease (LOAD) as well as to dilated cardiomyopathy.
 Form/Format    200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
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 Immunogen    Recombinant human full-length gamma catenin protein
 Cellular Localization    Cell Surface and Cytoplasmic
 Hu-chromosome Location    17q21
 Positive Control    A431, T47D or MCF-7 cells. Skin
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 Preparation and Storage    Antibody with azide - store at 2 to 8 degree C.
Antibody without azide - store at -20 to -80 degree C.
Antibody is stable for 24 months. Non-hazardous. No MSDS required.
 Other Notes    Small volumes of anti-JUP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-JUP antibody   

Flow Cytometry (FC/FACS), Immunofluorescence (IF), Western Blot (WB), Immunohistochemistry (IHC) Formalin

 Application Notes for anti-JUP antibody    FC/FACS: 0.5-1ug/million cells
IF: 1-2ug/ml
WB: 0.5-1.0ug/ml
IHC-F: 0.1-0.2ug/ml for 30 min at RT; Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 10-20 min followed by cooling at RT for 20 minutes.
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 Immunohistochemistry (IHC) of anti-JUP antibody    Formalin-fixed, paraffin-embedded human Cervical Carcinoma stained with Catenin, gamma Monoclonal Antibody (CTNG/1483)
anti-JUP antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-JUP antibody    Formalin-fixed, paraffin-embedded human Skin stained with Catenin, gamma Monoclonal Antibody (CTNG/1483)
anti-JUP antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for JUP. It may not necessarily be applicable to this product.
 NCBI GI #    4504811
 NCBI GeneID    3728
 NCBI Accession #    NP_002221.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_002230.3 [Other Products]
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 UniProt Primary Accession #    P14923 [Other Products]
 UniProt Secondary Accession #    Q15093; Q15151; Q7L3S5; Q86W21; Q9BWC4; Q9HCX9 [Other Products]
 UniProt Related Accession #    P14923 [Other Products]
 Molecular Weight    80-87kDa
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 NCBI Official Full Name    junction plakoglobin
 NCBI Official Synonym Full Names    junction plakoglobin
 NCBI Official Symbol    JUP [Similar Products]
 NCBI Official Synonym Symbols   
DP3; PDGB; PKGB; CTNNG; DPIII
[Similar Products]
 NCBI Protein Information    junction plakoglobin
 UniProt Protein Name    Junction plakoglobin
 UniProt Synonym Protein Names   
Catenin gamma; Desmoplakin III; Desmoplakin-3
 Protein Family    Junction plakoglobin
 UniProt Gene Name    JUP [Similar Products]
 UniProt Synonym Gene Names    CTNNG; DP3 [Similar Products]
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 NCBI Summary for JUP    This gene encodes a major cytoplasmic protein which is the only known constituent common to submembranous plaques of both desmosomes and intermediate junctions. This protein forms distinct complexes with cadherins and desmosomal cadherins and is a member of the catenin family since it contains a distinct repeating amino acid motif called the armadillo repeat. Mutation in this gene has been associated with Naxos disease. Alternative splicing occurs in this gene; however, not all transcripts have been fully described. [provided by RefSeq, Jul 2008]
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 UniProt Comments for JUP    Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton ().
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Product References and Citations for anti-JUP antibody

   Janssens, B., et al. 2001. alphaT-Catenin: a novel tissue-specific beta-cateninbinding protein mediating strong cell-cell adhesion. J. Cell Sci. 114:3177-3188.
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 Research Articles on JUP    1. gamma-Catenin acts as a tumor suppressor through context-dependent mechanisms in colorectal cancer.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-JUP antibodyPathways associated with anti-JUP antibody
 Reference Product  PubMed Publications
 CTNNA1 antibody  >79 publications with JUP and CTNNA1
 DSP antibody  >32 publications with JUP and DSP
 PKP2 antibody  >22 publications with JUP and PKP2
 DSG2 antibody  >19 publications with JUP and DSG2
 DSC2 antibody  >19 publications with JUP and DSC2
 APC antibody  >14 publications with JUP and APC
 ERBB2 antibody  >7 publications with JUP and ERBB2
 TCF4 antibody  >6 publications with JUP and TCF4
 DSG1 antibody  >5 publications with JUP and DSG1
 DSC1 antibody  >4 publications with JUP and DSC1
 Products by Pathway  Pathway Diagram
 Acute Myeloid Leukemia Pathway antibodies  Acute Myeloid Leukemia Pathway Diagram
 Acute Myeloid Leukemia Pathway antibodies  Acute Myeloid Leukemia Pathway Diagram
 Adherens Junctions Interactions Pathway antibodies  Adherens Junctions Interactions Pathway Diagram
 Arf6 Trafficking Events Pathway antibodies  Arf6 Trafficking Events Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
 Cell Junction Organization Pathway antibodies  Cell Junction Organization Pathway Diagram
 Cell-Cell Communication Pathway antibodies  Cell-Cell Communication Pathway Diagram
 Cell-cell Junction Organization Pathway antibodies  Cell-cell Junction Organization Pathway Diagram
Diseases associated with anti-JUP antibodyOrgans/Tissues associated with anti-JUP antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >133 publications with JUP and Neoplasms
 Cardiovascular Diseases Antibodies  >36 publications with JUP and Cardiovascular Diseases
 Heart Diseases Antibodies  >35 publications with JUP and Heart Diseases
 Heart Defects, Congenital Antibodies  >25 publications with JUP and Heart Defects, Congenital
 Breast Neoplasms Antibodies  >18 publications with JUP and Breast Neoplasms
 Lung Diseases Antibodies  >14 publications with JUP and Lung Diseases
 Kidney Diseases Antibodies  >10 publications with JUP and Kidney Diseases
 Cell Transformation, Neoplastic Antibodies  >9 publications with JUP and Cell Transformation, Neoplastic
 Immune System Diseases Antibodies  >8 publications with JUP and Immune System Diseases
 Liver Neoplasms Antibodies  >7 publications with JUP and Liver Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Heart Antibodies  >35 publications with JUP and Heart
 Skin Antibodies  >26 publications with JUP and Skin
 Lung Antibodies  >22 publications with JUP and Lung
 Muscle Antibodies  >18 publications with JUP and Muscle
 Lymph Antibodies  >17 publications with JUP and Lymph
 Lymph Node Antibodies  >17 publications with JUP and Lymph Node
 Blood Antibodies  >16 publications with JUP and Blood
 Kidney Antibodies  >12 publications with JUP and Kidney
 Mouth Antibodies  >10 publications with JUP and Mouth
 Bladder Antibodies  >9 publications with JUP and Bladder
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