NP_001244900.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
37,564 Da
NCBI Official Full Name
cathepsin L1 isoform 1 preproprotein
NCBI Official Synonym Full Names
cathepsin L
NCBI Protein Information
cathepsin L1; major excreted protein
UniProt Protein Name
Cathepsin L1
UniProt Synonym Protein Names
Cathepsin L; Major excreted protein; MEP
UniProt Synonym Gene Names
UniProt Entry Name
CATL1_HUMAN
NCBI Summary for CTSL1
The protein encoded by this gene is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. The encoded protein has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. This protein, which is a member of the peptidase C1 family, is a dimer composed of disulfide-linked heavy and light chains, both produced from a single protein precursor. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Apr 2012]
UniProt Comments for CTSL1
CTSL1: Important for the overall degradation of proteins in lysosomes. Belongs to the peptidase C1 family.
Protein type: EC 3.4.22.15; Motility/polarity/chemotaxis; Protease
Chromosomal Location of Human Ortholog: 9q21.33
Cellular Component: lysosomal lumen; extracellular space; lysosome; extracellular region; nucleus
Molecular Function: collagen binding; protein binding; proteoglycan binding; histone binding; fibronectin binding; cysteine-type endopeptidase activity; cysteine-type peptidase activity
Biological Process: antigen processing and presentation; collagen catabolic process; extracellular matrix disassembly; extracellular matrix organization and biogenesis; adaptive immune response; proteolysis involved in cellular protein catabolic process; toll-like receptor signaling pathway; innate immune response; antigen processing and presentation of exogenous peptide antigen via MHC class II; proteolysis
Research Articles on CTSL1
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Products associated with anti-CTSL1 antibody
Pathways associated with anti-CTSL1 antibody
Diseases associated with anti-CTSL1 antibody
Organs/Tissues associated with anti-CTSL1 antibody
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