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anti-Cacnb2 antibody :: Mouse Cav-beta 2 Ca+2 Channel Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS190548
Testing Data
Unit / Price
0.1 mg  /  $390 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Cav-beta 2 Ca+2 Channel (Cacnb2), Monoclonal Antibody

★Popular Item★
 Also Known As   

Anti-Cav beta 2 Ca+2 Channel Monoclonal Antibody

 Product Gene Name   

anti-Cacnb2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence Positions    189-205
 Chromosome Location    Chromosome: 17; NC_005116.2 (88832905..89078870). Location: 17q12.3
 3D Structure    ModBase 3D Structure for Q8VGC3
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    S8b-1
 Host    Mouse
 Species Reactivity    Human, mouse, rat
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 Specificity    Cav beta 2 Ca+2 Channel
This antibody recognizes human, mouse, and rat Cavbeta2. It does not cross-react with Cav beta1, Cav beta3, or Cav beta4.
 Form/Format    100ug in PBS, pH 7.4; 50% glycerol, 0.09% sodium azide. Purified by Protein G affinity chromatography.
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 Antigen    Synthetic peptide corresponding to aa 189-205 of rat Cavbeta2 (RSPKPSANSVTSPHSKE) (accession no.NP_446303).
 Dilution Instructions    Dilute in PBS or medium which is identical to that used in the assay system.
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 Preparation and Storage    This antibody is stable for at least one (1) year at -20 degree C. Avoid repeated freezing and thawing.
 Other Notes    Small volumes of anti-Cacnb2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for Cacnb2 purchase    Ion channels like anti Cav beta 2 calcium channel - CACNB - are localized to cell plasma membrane and activation with ligands results in cellular responses. With limited information about molecular subunit composition for active voltage dependent calcium channels, MyBiosource's mouse monoclonal antibody recognized beta specifically and not gamma or alpha. Cell experiments to determine functional properties commonly utilize stable transfections of human or mouse gene plasmid lenti activation system expression or ShRNA plasmid sc knockdown. The ability to distinguish subtypes of expression in either stably puromycin type selection or stable gene silencing puromyocin selection requires our pan species [ human mouse rat ] CACNB2 antibody. Compared to rabbit antibodies, our Cav B2 calcium channel voltage antibody recognizes protein in lysates, IHC and is suitable for ELISA kits development. Value pricing, rapid shipping and promotional items make this product and all our products top sellers worldwide. Find us at MyBiosource.com.
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Related Product Information for anti-Cacnb2 antibody

   Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient. Cavbeta subunits are involved in the transport of the pore-forming alpha1 subunit to the plasma membrane. They also shield an ER Retention signal on the alpha1 subunit, thereby guiding the poreforming subunit to the target membrane.
 Applications Tested/Suitable for anti-Cacnb2 antibody   

Immunoblot; Immunohistochemistry; Immunocytochemistry; Immunofluorescence

 Application Notes for anti-Cacnb2 antibody    Immunoblotting: use at 1-10ug/ml. A band of ~78kDa is detected. Immunohistochemistry and Immunocytochemistry: use at 0.1-1ug/ml. Immunofluorescence: use at 1-10ug/ml. These are recommended concentrations. User should determine optimal concentrations for their application. Positive control: Rat brain lysate
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 Testing Data of anti-Cacnb2 antibody    anti-Cacnb2 antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for Cacnb2. It may not necessarily be applicable to this product.
 NCBI GI #    16758716
 NCBI GeneID    116600
 NCBI Accession #    NP_446303.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_053851.1 [Other Products]
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 UniProt Primary Accession #    Q8VGC3 [Other Products]
 UniProt Secondary Accession #    Q811Q6; Q811Q7; Q91ZJ8; Q9QUU7 [Other Products]
 UniProt Related Accession #    Q8VGC3 [Other Products]
 Molecular Weight    73,226 Da [Similar Products]
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 NCBI Official Full Name    voltage-dependent L-type calcium channel subunit beta-2
 NCBI Official Synonym Full Names    calcium channel, voltage-dependent, beta 2 subunit
 NCBI Official Symbol    Cacnb2 [Similar Products]
 NCBI Official Synonym Symbols   
Cacnlb2
[Similar Products]
 NCBI Protein Information    voltage-dependent L-type calcium channel subunit beta-2; CAB2; calcium channel voltage-dependent subunit beta 2
 UniProt Protein Name    Voltage-dependent L-type calcium channel subunit beta-2
 UniProt Synonym Protein Names   
Calcium channel voltage-dependent subunit beta 2
 Protein Family    Voltage-dependent L-type calcium channel
 UniProt Gene Name    Cacnb2 [Similar Products]
 UniProt Synonym Gene Names    Cacnlb2 [Similar Products]
 UniProt Entry Name    CACB2_RAT
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 NCBI Summary for Cacnb2    auxillary subunit of the L-type Ca(2+) channel [RGD]
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 UniProt Comments for Cacnb2    CACNB2: The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting. Defects in CACNB2 are the cause of Brugada syndrome type 4 (BRGDA4). A heart disease characterized by the association of Brugada syndrome with shortened QT intervals. Brugada syndrome is a tachyarrhythmia characterized by right bundle branch block and ST segment elevation on an electrocardiogram (ECG). It can cause the ventricles to beat so fast that the blood is prevented from circulating efficiently in the body. When this situation occurs (called ventricular fibrillation), the individual will faint and may die in a few minutes if the heart is not reset. Belongs to the calcium channel beta subunit family. 8 isoforms of the human protein are produced by alternative splicing.

Protein type: Channel, calcium

Cellular Component: voltage-gated calcium channel complex; sarcolemma

Molecular Function: voltage-gated calcium channel activity; protein domain specific binding; calcium channel regulator activity; high voltage-gated calcium channel activity; phosphoprotein binding; protein kinase binding

Biological Process: synaptic transmission; visual perception; calcium ion transport; positive regulation of calcium ion transport; neuromuscular junction development
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 Research Articles on Cacnb2    1. This study provides the first evidence to demonstrate that LTCC beta2 subunit is coupled with the movement of signals in the mechanism of activation of NKA-mediated crosstalk with LTCC.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-Cacnb2 antibodyPathways associated with anti-Cacnb2 antibody
 Reference Product  PubMed Publications
 Cacna1c antibody  >8 publications with Cacnb2 and Cacna1c
 Cacna1a antibody  >4 publications with Cacnb2 and Cacna1a
 Products by Pathway  Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
 Cardiac Muscle Contraction Pathway antibodies  Cardiac Muscle Contraction Pathway Diagram
 Cardiac Muscle Contraction Pathway antibodies  Cardiac Muscle Contraction Pathway Diagram
 Depolarization Of The Presynaptic Terminal Triggers The Opening Of Calcium Channels Pathway antibodies  Depolarization Of The Presynaptic Terminal Triggers The Opening Of Calcium Channels Pathway Diagram
 Diabetes Pathways antibodies  Diabetes Pathways Diagram
 Dilated Cardiomyopathy Pathway antibodies  Dilated Cardiomyopathy Pathway Diagram
 Dilated Cardiomyopathy Pathway antibodies  Dilated Cardiomyopathy Pathway Diagram
 Hypertrophic Cardiomyopathy (HCM) Pathway antibodies  Hypertrophic Cardiomyopathy (HCM) Pathway Diagram
 Hypertrophic Cardiomyopathy (HCM) Pathway antibodies  Hypertrophic Cardiomyopathy (HCM) Pathway Diagram
Diseases associated with anti-Cacnb2 antibodyOrgans/Tissues associated with anti-Cacnb2 antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >7 publications with Cacnb2 and Nervous System Diseases
 Brugada Syndrome Antibodies  >5 publications with Cacnb2 and Brugada Syndrome
 Death, Sudden, Cardiac Antibodies  >4 publications with Cacnb2 and Death, Sudden, Cardiac
 Congenital Abnormalities Antibodies  >2 publications with Cacnb2 and Congenital Abnormalities
 Hypertension Antibodies  >2 publications with Cacnb2 and Hypertension
 Myocardial Ischemia Antibodies  >1 publications with Cacnb2 and Myocardial Ischemia
 Long QT Syndrome Antibodies  >1 publications with Cacnb2 and Long QT Syndrome
 Lung Neoplasms Antibodies  >1 publications with Cacnb2 and Lung Neoplasms
 Lung Diseases Antibodies  >1 publications with Cacnb2 and Lung Diseases
 Carcinoma, Small Cell Antibodies  >1 publications with Cacnb2 and Carcinoma, Small Cell
 Organ/Tissue Name  Pubmed Publications
 Heart Antibodies  >12 publications with Cacnb2 and Heart
 Brain Antibodies  >9 publications with Cacnb2 and Brain
 Kidney Antibodies  >3 publications with Cacnb2 and Kidney
 Inner Ear Antibodies  >1 publications with Cacnb2 and Inner Ear
 Embryonic Tissue Antibodies  >1 publications with Cacnb2 and Embryonic Tissue
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