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anti-RARRES2 antibody :: Mouse anti-Human Chemerin Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS690212 anti-RARRES2 antibody
Unit / Price
0.1 mg  /  $460 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Chemerin (RARRES2), Monoclonal Antibody

 Also Known As   

Mouse Anti-Human Chemerin

 Product Synonym Names    RARRES2; TIG2; HP10433
 Product Gene Name   

anti-RARRES2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 7; NC_000007.14 (150333944..150341683, complement). Location: 7q36.1
 OMIM    601973
 3D Structure    ModBase 3D Structure for Q99969
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 Clonality    Monoclonal
 Isotype    IgG2
 Clone Number    (6G32)
 Host    Mouse
 Species Reactivity    Human
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 Form/Format    Lyophilized
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 Antibody Generation    This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse) immunized with human recombinant protein of Chemerin.
 Reconstitution    Reconstitute the antibody with 200 ul sterile PBS and the final concentration is 500 ug/ml.
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 Preparation and Storage    Lyophilized samples are stable for 2 years from date of receipt when stored at -70 degree C. Reconstituted antibody can be aliquoted and stored frozen at < -20 degree C for at least for six months without detectable loss of activity.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-RARRES2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-RARRES2 antibody

   Chemerin, also known as Tazarotene-induced Gene 2, (Tig-2), is a member of the Cystatin superfamily. Chemerin is synthesized as a 163 aa precursor that contains a hydrophobic 20 aa N-terminal sequence, an intervening 137 aa Cystatin fold-containing domain, and a six aa C-terminal prosegment. It is activated by proteases of the coagulation, fibrinolytic, and inflammatory cascades. Chemerin is a chemoattractant for cells bearing the Chem R23 receptor, including plasmacytoid dendritic cells and tissue macrophages.
 Applications Tested/Suitable for anti-RARRES2 antibody   

Western Blot (WB)

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NCBI/Uniprot data below describe general gene information for RARRES2. It may not necessarily be applicable to this product.
 NCBI GI #    4506427
 NCBI GeneID    5919
 NCBI Accession #    NP_002880.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_002889.3 [Other Products]
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 UniProt Primary Accession #    Q99969 [Other Products]
 UniProt Secondary Accession #    Q7LE02 [Other Products]
 UniProt Related Accession #    Q99969 [Other Products]
 Molecular Weight    18,618 Da [Similar Products]
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 NCBI Official Full Name    retinoic acid receptor responder protein 2
 NCBI Official Synonym Full Names    retinoic acid receptor responder (tazarotene induced) 2
 NCBI Official Symbol    RARRES2 [Similar Products]
 NCBI Official Synonym Symbols   
TIG2; HP10433
[Similar Products]
 NCBI Protein Information    retinoic acid receptor responder protein 2; chemerin; RAR-responsive protein TIG2; tazarotene-induced gene 2 protein
 UniProt Protein Name    Retinoic acid receptor responder protein 2
 UniProt Synonym Protein Names   
Chemerin; RAR-responsive protein TIG2; Tazarotene-induced gene 2 protein
 Protein Family    Retinoic acid receptor responder protein
 UniProt Gene Name    RARRES2 [Similar Products]
 UniProt Synonym Gene Names    TIG2 [Similar Products]
 UniProt Entry Name    RARR2_HUMAN
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 NCBI Summary for RARRES2    This gene encodes a secreted chemotactic protein that initiates chemotaxis via the ChemR23 G protein-coupled seven-transmembrane domain ligand. Expression of this gene is upregulated by the synthetic retinoid tazarotene and occurs in a wide variety of tissues. The active protein has several roles, including that as an adipokine, and is truncated on both termini from the proprotein. [provided by RefSeq, Dec 2008]
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 UniProt Comments for RARRES2    Function: Adipocyte-secreted protein (adipokine) that regulates adipogenesis, metabolism and inflammation through activation of the chemokine-like receptor 1 (CMKLR1). Its other ligands include G protein-coupled receptor 1 (GPR1) and chemokine receptor-like 2 (CCRL2). Positively regulates adipocyte differentiation, modulates the expression of adipocyte genes involved in lipid and glucose metabolism and might play a role in angiogenesis, a process essential for the expansion of white adipose tissue. Also acts as a proinflammatory adipokine, causing an increase in secretion of proinflammatory and prodiabetic adipokines, which further impair adipose tissue metabolic function and have negative systemic effects including impaired insulin sensitivity, altered glucose and lipid metabolism, and a decrease in vascular function in other tissues. Can have both pro- and anti-inflammatory properties depending on the modality of enzymatic cleavage by different classes of proteases. Acts as a chemotactic factor for leukocyte populations expressing CMKLR1, particularly immature plasmacytoid dendritic cells, but also immature myeloid DCs, macrophages and natural killer cells. Exerts an anti-inflammatory role by preventing TNF/TNFA-induced VCAM1 expression and monocytes adhesion in vascular endothelial cells. The effect is mediated via inhibiting activation of NF-kappa-B and CRK/p38 through stimulation of AKT1/NOS3 signaling and nitric oxide production. Its dual role in inflammation and metabolism might provide a link between chronic inflammation and obesity, as well as obesity-related disorders such as type 2 diabetes and cardiovascular disease. Exhibits an antimicrobial function in the skin. Ref.8 Ref.10 Ref.11 Ref.12 Ref.14 Ref.17 Ref.20

Subcellular location: Secreted

Potential Ref.12.

Tissue specificity: Expressed at the highest levels in placenta, liver, and white adipose tissue (WAT), and to a lesser extent in many other tissues such as lung, brown adipose tissue, heart, ovary, kidney, skeletal muscle and pancreas. Within WAT, expression is enriched in adipocytes as compared to the stromal vascular fraction. Expression and secretion increases dramatically with adipogenesis. Highly expressed in skin (basal and suprabasal layers of the epidermis, hair follicles and endothelial cells). Expression is elevated in numerous metabolic and inflammatory diseases including psoriasis, obesity, type 2 diabetes, metabolic syndrome and cardiovascular disease. Ref.10 Ref.11 Ref.20

Induction: Inhibited in psoriatic lesions. Activated by tazarotene in skin rafts and in the epidermis of psoriatic lesions. Ref.1

Post-translational modification: Secreted in an inactive precursor form, prochemerin, which is proteolytically processed by a variety of extracellular proteases to generate forms with differing levels of bioactivity. For example, the removal of six amino acids results in chemerin-157, which exhibits the highest activity, while removal of seven amino acids results in chemerin-156 which has slightly less activity. Some proteases are able to cleave at more than one site and chemerin forms may be sequentially processed by different enzymes to modulate activity levels. The coordinated expression and activity of chemerin-modifying enzymes is essential for regulating its bioactivation, inactivation and, consequently, biological function. Cathepsin G cleaves seven C-terminal amino acids from prochemerin (chemerin-156), elastase is able to cleave six (chemerin-157), eight (chemerin-155) or eleven (chemerin-152), plasmin cleaves five amino acids (chemerin-158), and tryptase cleaves five (chemerin-158) or eight (chemerin-155). Multiple cleavages might be required to fully activate chemerin, with an initial tryptase cleavage resulting in chemerin with low activity (chemerin-158), and a second cleavage by carboxypeptidase N or B producing highly active chemerin (chemerin-157).
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 Research Articles on RARRES2    1. chemerin (p<0.01) and leptin (p<0.01) were significantly decreased after fasting. For leptin, this decrease was also significant after 36 h (p<0.01). Adiponectin levels remained unchanged.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-RARRES2 antibodyDiseases associated with anti-RARRES2 antibody
 Reference Product  PubMed Publications
 CMKLR1 antibody  >2 publications with RARRES2 and CMKLR1
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >4 publications with RARRES2 and Neoplasms
 Adenocarcinoma Antibodies  >1 publications with RARRES2 and Adenocarcinoma
 Weight Gain Antibodies  >1 publications with RARRES2 and Weight Gain
 Infertility, Female Antibodies  >1 publications with RARRES2 and Infertility, Female
 Nervous System Diseases Antibodies  >1 publications with RARRES2 and Nervous System Diseases
 Hypertension Antibodies  >1 publications with RARRES2 and Hypertension
 Necrosis Antibodies  >1 publications with RARRES2 and Necrosis
Organs/Tissues associated with anti-RARRES2 antibody
 Organ/Tissue Name  Pubmed Publications
 Connective Tissue Antibodies  >3 publications with RARRES2 and Connective Tissue
 Adipose Tissue Antibodies  >3 publications with RARRES2 and Adipose Tissue
 Bone Antibodies  >2 publications with RARRES2 and Bone
 Brain Antibodies  >2 publications with RARRES2 and Brain
 Uterus Antibodies  >1 publications with RARRES2 and Uterus
 Eye Antibodies  >1 publications with RARRES2 and Eye
 Adrenal Gland Antibodies  >1 publications with RARRES2 and Adrenal Gland
 Ovary Antibodies  >1 publications with RARRES2 and Ovary
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