Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
Fax 1.858.633.0166    Email 
menu1 Home Products Ordering Company Help menu7
   MyBioSource rightarrow Antibody rightarrow CHRDL1 rightarrow Monoclonal CHRDL1  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
Our Best Sellers moreseparator
 • SULT1A1 Antibody
 • Ku80 Antibody
 • enolase 3 (beta, muscle) (ENO3) ELISA Kit
 • Poliomyelitis IgG ELISA Kit
 • Hepatocyte Growth Factor Activator (HGFAC) ELISA Kit
 • Signal recognition particle subunit SRP72 (SRP72) Recombinant Protein
 • Wnt3a Antibody
 • Protein tyrosine phosphatase (PTP) ELISA Kit
 • MSN Antibody
 • PTK2 Antibody
 • 2-amino-3-carboxymuconate-6 -semialdehyde decarboxylase (ACMS... ELISA Kit
 • Cathepsin L1 (CTSL1) ELISA Kit
 • Anti-HBV surface Antigen Antibody (Anti-HBV) ELISA Kit
 • Fibrinopeptide B (FPB) ELISA Kit
 downarrow more ...
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

anti-CHRDL1 antibody :: Mouse anti-Human Chordin-like Protein 1 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS608882 anti-CHRDL1 antibody
Unit / Price
0.1 mL  /  $685 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Chordin-like Protein 1 (CHRDL1), Monoclonal Antibody

 Also Known As   

Chordin-like Protein 1 (CHL, CHRDL1, dA141H5.1, Neuralin-1, NRLN1, Neurogenesin-1, Ventroptin, VOPT) (Azide Free)

 Product Synonym Names    Anti -Chordin-like Protein 1 (CHL, CHRDL1, dA141H5.1, Neuralin-1, NRLN1, Neurogenesin-1, Ventroptin, VOPT) (Azide Free)
 Product Gene Name   

anti-CHRDL1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 Chromosome Location    Chromosome: X; NC_000023.10 (109917084..110039286, complement). Location: Xq23
 3D Structure    ModBase 3D Structure for Q59FB2
Section Bar
 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    10B2236
 Host    Mouse
 Species Reactivity    Human
Section Bar
 Specificity    Recognizes human CHRDL1.
 Purity/Purification    Affinity Purified
Purified by Protein A affinity chromatography.
 Form/Format    Supplied as a liquid in PBS, pH 7.2. No preservative added (Azide free).
Section Bar
 Immunogen    Recombinant protein corresponding to a portion of amino acids within aa347-457 of human CHRDL1.
 Hybridoma    Sp2/0 myeloma cells with spleen cells from Balb/c mice.
Section Bar
 Preparation and Storage    May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile 40-50% glycerol, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
 Other Notes    Small volumes of anti-CHRDL1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar

Related Product Information for anti-CHRDL1 antibody

   This gene encodes an antagonist of bone morphogenetic protein 4. The encoded protein may play a role in topographic retinotectal projection and in the regulation of retinal angiogenesis in response to hypoxia. Alternatively spliced transcript variants encoding different isoforms have been described.
 Product Categories/Family for anti-CHRDL1 antibody    Antibodies; Abs to Stem Cell Research
 Applications Tested/Suitable for anti-CHRDL1 antibody   

ELISA (EL/EIA), Western Blot (WB)

 Application Notes for anti-CHRDL1 antibody    Suitable for use in ELISA and Western Blot.
Dilution: Western Blot: 1:500-1:1000
ELISA: 1ug/ml-3ng/ml
Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for CHRDL1. It may not necessarily be applicable to this product.
 NCBI GI #    221316561
 NCBI GeneID    91851
 NCBI Accession #    NP_001137453.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001143981.1 [Other Products]
Section Bar
 UniProt Primary Accession #    Q59FB2 [Other Products]
 UniProt Related Accession #    Q59FB2; Q9BU40 [Other Products]
 Molecular Weight    49,664 Da [Similar Products]
Table BarTOPTable Bar
 NCBI Official Full Name    chordin-like protein 1 isoform 1
 NCBI Official Synonym Full Names    chordin-like 1
 NCBI Official Symbol    CHRDL1 [Similar Products]
 NCBI Official Synonym Symbols   
CHL; VOPT; NRLN1; dA141H5.1
[Similar Products]
 NCBI Protein Information    chordin-like protein 1; neuralin 1; neuralin-1; ventroptin; neurogenesin-1; OTTHUMP00000023853; OTTHUMP00000023854; OTTHUMP00000216337; OTTHUMP00000216338; OTTHUMP00000226627
 UniProt Protein Name    Chordin-like 1 variant
 Protein Family    Chordin-like protein
 UniProt Entry Name    Q59FB2_HUMAN
Section Bar
 NCBI Summary for CHRDL1    This gene encodes an antagonist of bone morphogenetic protein 4. The encoded protein may play a role in topographic retinotectal projection and in the regulation of retinal angiogenesis in response to hypoxia. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq]
Section Bar
 UniProt Comments for CHRDL1    CHRDL1: Antagonizes the function of BMP4 by binding to it and preventing its interaction with receptors. Alters the fate commitment of neural stem cells from gliogenesis to neurogenesis. Contributes to neuronal differentiation of neural stem cells in the brain by preventing the adoption of a glial fate. May play a crucial role in dorsoventral axis formation. May play a role in embryonic bone formation. May also play an important role in regulating retinal angiogenesis through modulation of BMP4 actions in endothelial cells. Plays a role during anterior segment eye development. Defects in CHRDL1 are the cause of megalocornea type 1, X-linked (MGC1). MGC1 is an eye disorder in which the corneal diameter is bilaterally enlarged (greater than 13 mm) without an increase in intraocular pressure. It may also be referred to as anterior megalophthalmos, since the entire anterior segment is larger than normal. Features of megalocornea in addition to a deep anterior chamber include astigmatic refractive errors, atrophy of the iris stroma, miosis secondary to decreased function of the dilator muscle, iridodonesis, and tremulousness, subluxation, or dislocation of the lens. Whereas most affected individuals exhibit normal ocular function, complications include cataract development and glaucoma following lenticular dislocation or subluxation. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: Xq23

Cellular Component: extracellular region

Biological Process: BMP signaling pathway; neuron differentiation; ossification; eye development; compound eye development; negative regulation of BMP signaling pathway

Disease: Megalocornea
Table BarTOPTable Bar
 Research Articles on CHRDL1    1. reports the cloning of chick ventroptin and its importance in topographic retinotectal projection
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with anti-CHRDL1 antibodyPathways associated with anti-CHRDL1 antibody
 Reference Product  PubMed Publications
 BMP4 antibody  >2 publications with CHRDL1 and BMP4
 Products by Pathway  Pathway Diagram
 BMP Receptor Signaling Pathway antibodies  BMP Receptor Signaling Pathway Diagram
 Signaling By BMP Pathway antibodies  Signaling By BMP Pathway Diagram
Organs/Tissues associated with anti-CHRDL1 antibody
 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >12 publications with CHRDL1 and Nerve
 Eye Antibodies  >12 publications with CHRDL1 and Eye
 Bone Antibodies  >10 publications with CHRDL1 and Bone
 Embryonic Tissue Antibodies  >5 publications with CHRDL1 and Embryonic Tissue
 Kidney Antibodies  >3 publications with CHRDL1 and Kidney
 Ganglia Antibodies  >1 publications with CHRDL1 and Ganglia
 Connective Tissue Antibodies  >1 publications with CHRDL1 and Connective Tissue
 Muscle Antibodies  >1 publications with CHRDL1 and Muscle
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions