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anti-CLTA antibody :: Mouse Clathrin, Light Chain Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS439879
Unit / Price
0.02 mg (With BSA & Azide at 0.2mg/ml)  /  $190 +1 FREE 8GB USB
0.1 mg (With BSA & Azide at 0.2mg/ml)  /  $300 +1 FREE 8GB USB
0.1 mg (Without BSA & Azide at 1mg/ml)  /  $310 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Clathrin, Light Chain (CLTA), Monoclonal Antibody

★Popular Item★
 Also Known As   

Clathrin, Light Chain

 Product Synonym Names    Clathrin light chain A; Clathrin light chain B; Clathrin light chain LCA; Clathrin light chain LCB; Clathrin light polypeptide A; Clathrin light polypeptide B; Clathrin, light polypeptide (Lca); Clathrin, light polypeptide (Lcb); CLTA; CLTB
 Product Gene Name   

anti-CLTA antibody

[Similar Products]
 Product Synonym Gene Name    CLTB [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for P09496
 Clonality    Monoclonal
 Isotype    IgG2b, kappa
 Clone Number    SPM174
 Host    Mouse
 Species Reactivity    Human. Others not known.
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 Specificity    Recognizes proteins of 31-44kDa, which are identified as Clathrin Light Chains (both A & B). Clathrin is composed of three heavy chains and three light chains, which associate non-covalently to form a triskelion structure. Clathrin light chain regulates the self-assembly of triskelions onto intracellular membranes. Clathrin light chain subunits (LCA and LCB) contribute to regulation of coated vesicle formation to sort proteins during receptor-mediated endocytosis and organelle biogenesis. LCA and LCB are encoded by two discrete genes. They share only 60% homology, and have certain features in common. Both LCA and LCB undergo alternative mRNA splicing, which results in the generation of tissue-specific isoforms.
 Form/Format    200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
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 Immunogen    Purified recombinant N-terminal fragment of human Clathrin Light Chain
 Cellular Localization    Cytoplasmic
 Hu-chromosome Location    9p13.3
 Positive Control    HeLa cells. Placenta or Prostate Carcinoma.
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 Preparation and Storage    Antibody with azide - store at 2 to 8 degree C.
Antibody without azide - store at -20 to -80 degree C.
Antibody is stable for 24 months. Non-hazardous. No MSDS required.
 Other Notes    Small volumes of anti-CLTA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-CLTA antibody   

Flow Cytometry (FC/FACS), Immunofluorescence (IF), Western Blot (WB), Immunohistochemistry (IHC) Formalin

 Application Notes for anti-CLTA antibody    FC/FACS: 0.5-1ug/million cells
IF: 1-2ug/ml
WB: 0.5-1ug/ml
IHC-F: 0.5-1ug/ml for 30 min at RT; Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes.
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 Immunohistochemistry (IHC) of anti-CLTA antibody    Formalin-fixed, paraffin-embedded Human Pancreas stained with Clathrin, LC Monoclonal Antibody (SPM174).
anti-CLTA antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-CLTA antibody    Formalin-fixed, paraffin-embedded human Prostate Carcinoma stained with p27 Monoclonal Antibody (SX53G8)
anti-CLTA antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for CLTA. It may not necessarily be applicable to this product.
 NCBI GI #    115527060
 NCBI GeneID    1211
 NCBI Accession #    NP_001070145.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001076677.2 [Other Products]
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 UniProt Primary Accession #    P09496 [Other Products]
 UniProt Secondary Accession #    Q2XPN5; Q53XZ1; A8K4W3; B4DIN1; F5H6N3 [Other Products]
 UniProt Related Accession #    P09496 [Other Products]
 Molecular Weight    31-44kDa
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 NCBI Official Full Name    clathrin light chain A isoform c
 NCBI Official Synonym Full Names    clathrin light chain A
 NCBI Official Symbol    CLTA [Similar Products]
 NCBI Official Synonym Symbols   
LCA
[Similar Products]
 NCBI Protein Information    clathrin light chain A
 UniProt Protein Name    Clathrin light chain A
 Protein Family    Clathrin
 UniProt Gene Name    CLTA [Similar Products]
 UniProt Synonym Gene Names    Lca [Similar Products]
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 NCBI Summary for CLTA    Clathrin is a large, soluble protein composed of heavy and light chains. It functions as the main structural component of the lattice-type cytoplasmic face of coated pits and vesicles which entrap specific macromolecules during receptor-mediated endocytosis. This gene encodes one of two clathrin light chain proteins which are believed to function as regulatory elements. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 8 and 12. [provided by RefSeq, May 2010]
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 UniProt Comments for CLTA    Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge (PubMed:15858577, PubMed:21297582).
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Product References and Citations for anti-CLTA antibody

   Jackson, A.P., et al. 1988. Structure of human clathrin light chains. Conservation of light chain polymorphism in three mammalian species. J. Biol. Chem. 263: 16688-16695.
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 Research Articles on CLTA    1. Data indicate that clathrin-mediated endocytosis of proto-oncogene protein erbB-3 (ErbB3) is depending on epsin-1.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CLTA antibodyPathways associated with anti-CLTA antibody
 Reference Product  PubMed Publications
 CD4 antibody  >7 publications with CLTA and CD4
 CLTB antibody  >5 publications with CLTA and CLTB
 CLTC antibody  >3 publications with CLTA and CLTC
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Arf1 Pathway antibodies  Arf1 Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 BMP Signaling Pathway antibodies  BMP Signaling Pathway Diagram
 BMP Signaling Pathway antibodies  BMP Signaling Pathway Diagram
 Bacterial Invasion Of Epithelial Cells Pathway antibodies  Bacterial Invasion Of Epithelial Cells Pathway Diagram
 Bacterial Invasion Of Epithelial Cells Pathway antibodies  Bacterial Invasion Of Epithelial Cells Pathway Diagram
 C-MYB Transcription Factor Network Pathway antibodies  C-MYB Transcription Factor Network Pathway Diagram
 Clathrin Derived Vesicle Budding Pathway antibodies  Clathrin Derived Vesicle Budding Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
Diseases associated with anti-CLTA antibodyOrgans/Tissues associated with anti-CLTA antibody
 Disease Name  Pubmed Publications
 Skin Neoplasms Antibodies  >2 publications with CLTA and Skin Neoplasms
 Heart Diseases Antibodies  >2 publications with CLTA and Heart Diseases
 Nervous System Diseases Antibodies  >1 publications with CLTA and Nervous System Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >9 publications with CLTA and Blood
 Heart Antibodies  >2 publications with CLTA and Heart
 Lung Antibodies  >2 publications with CLTA and Lung
 Skin Antibodies  >2 publications with CLTA and Skin
 Spleen Antibodies  >1 publications with CLTA and Spleen
 Muscle Antibodies  >1 publications with CLTA and Muscle
 Bone Antibodies  >1 publications with CLTA and Bone
 Lymph Node Antibodies  >1 publications with CLTA and Lymph Node
 Lymph Antibodies  >1 publications with CLTA and Lymph
 Umbilical Cord Antibodies  >1 publications with CLTA and Umbilical Cord
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